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    PERCUTANEOUSLY DELIVERABLE HEART VALVE INCLUDING FOLDED MEMBRANE CUSPS WITH INTEGRAL LEAFLETS
    1.
    发明申请
    PERCUTANEOUSLY DELIVERABLE HEART VALVE INCLUDING FOLDED MEMBRANE CUSPS WITH INTEGRAL LEAFLETS 有权
    非常可交付的心脏瓣膜，包括具有整体叶片的折叠膜片

    公开(公告)号：US20120185038A1

    公开(公告)日：2012-07-19

    申请号：US13326196

    申请日：2011-12-14

    申请人： R. David FISH ,  Eduaro INDUNI ,  David PANIAGUA

    发明人： R. David FISH ,  Eduaro INDUNI ,  David PANIAGUA

    IPC分类号： A61F2/24 ,  B31B1/26

    CPC分类号： A61F2/2415 ,  A61F2/2418 ,  A61F2220/0075 ,  A61F2230/0054

    摘要： A transcatheter, percutaneously implantable, prosthetic heart valve is provided that comprises a lattice frame and two or more integrated cusp and leaflet folded structures attached to the lattice frame. The two or more integrated cusp and leaflet folded structures each comprise a flat sheet of biocompatible membrane that is folded to include a substantially conical shape according to a flat folding pattern. The substantially conical shape is further formed by joining apposing sides of the substantially conical shape along a seam. The two or more integrated cusp and leaflet folded structures are each attached along their respective seams to the lattice frame in a direction substantially parallel to an axis of the lattice frame. Embodiments of valves described herein have application within the entire vascular system.

    摘要翻译： 提供经导管，经皮可植入的假体心脏瓣膜，其包括格子框架和附接到格子框架的两个或更多个集成的尖端和小叶折叠结构。 两个或多个集成的尖头和小叶折叠结构各自包括生物相容性膜的平片，其被折叠以包括基于平坦折叠图案的基本上圆锥形的形状。 基本上圆锥形的形状通过沿着接缝连接基本上圆锥形的侧面而进一步形成。 两个或多个集成的尖头和小叶折叠结构各自沿着它们各自的接缝沿基本上平行于格子框架的轴线的方向附接到格子框架。 本文所述的阀的实施例在整个血管系统内具有应用。

    PERCUTANEOUSLY DELIVERABLE HEART VALVE AND METHODS ASSOCIATED THEREWITH
    2.
    发明申请
    PERCUTANEOUSLY DELIVERABLE HEART VALVE AND METHODS ASSOCIATED THEREWITH 有权
    非常可交付的心脏瓣膜及其相关方法

    公开(公告)号：US20110301700A1

    公开(公告)日：2011-12-08

    申请号：US13038361

    申请日：2011-03-01

    申请人： R. David FISH ,  David PANIAGUA

    发明人： R. David FISH ,  David PANIAGUA

    IPC分类号： A61F2/24 ,  B32B38/16 ,  B23P11/00

    CPC分类号： A61F2/2427 ,  A61F2/0095 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2220/0075 ,  Y10T29/49908 ,  Y10T156/10

    摘要： A prosthetic heart valve implantable by catheter without surgery includes a substantially “dry” membrane or tissue material. In at least one embodiment, the tissue is folded in a dry state to form a tissue leaflet assembly that is then attached to a frame to form an implantable prosthetic heart valve. Alternatively, one or more tissue leaflets are operatively associated with a frame to form an implantable prosthetic heart valve. The implantable prosthetic heart valve is subsequently pre-mounted on an integrated catheter delivery system. The catheter delivery system that includes the implantable prosthetic heart valve is then packaged and transported while the tissue remains dry. The implantable prosthetic heart valve, while remaining substantially dry, can then be implanted into the receiving patient.

    摘要翻译： 通过没有手术的导管植入的假体心脏瓣膜包括基本上“干”的膜或组织材料。 在至少一个实施例中，组织以干燥状态折叠以形成组织小叶组件，然后将组织小叶组件附接到框架以形成可植入的假体心脏瓣膜。 或者，一个或多个组织小叶与框架可操作地相关联以形成可植入假体心脏瓣膜。 随后将可植入式假体心脏瓣膜预先安装在集成的导管递送系统上。 包括可植入假体心脏瓣膜的导管递送系统然后在组织保持干燥时被包装和运输。 可植入假体心脏瓣膜虽然保持基本上干燥，然后可以植入接受患者。

    PERCUTANEOUSLY DELIVERABLE HEART OR BLOOD VESSEL VALVE WITH FRAME HAVING ABLUMINALLY SITUATED TISSUE MEMBRANE
    4.
    发明申请
    PERCUTANEOUSLY DELIVERABLE HEART OR BLOOD VESSEL VALVE WITH FRAME HAVING ABLUMINALLY SITUATED TISSUE MEMBRANE 审中-公开
    非常可输送的心脏或血管血管与具有外壳形状的组织膜的框架

    公开(公告)号：US20120078356A1

    公开(公告)日：2012-03-29

    申请号：US13243980

    申请日：2011-09-23

    申请人： R. David FISH ,  David PANIAGUA ,  Eduardo INDUNI

    发明人： R. David FISH ,  David PANIAGUA ,  Eduardo INDUNI

    IPC分类号： A61F2/24 ,  B21D51/16

    CPC分类号： A61F2/2418 ,  A61F2/2415 ,  A61F2/2433 ,  A61F2/2475 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0054 ,  Y10T29/49405

    摘要： A prosthetic valve implantable by catheter without surgery includes a frame with an abluminal surface extending between a proximal end of the frame and a distal end of the frame, and a single layer of a biocompatible membrane material mounted to the abluminal surface of the frame. The single layer of biocompatible membrane is located such that an interior surface of the membrane sheet extends between the proximal end of the frame and the distal end of the frame, and resides radially exterior the abluminal surface of the frame. In at least one embodiment, the disposition of membrane sheet at all points of attachment is entirely exterior/abluminal to the frame, such that no part of the abluminal surface of the membrane sheet contacts the frame.

    摘要翻译： 可以通过没有手术的导管植入的假体瓣膜包括具有在框架的近端和框架的远端之间延伸的腹腔表面的框架，以及安装到框架的外侧表面的单层生物相容性膜材料。 单层生物相容性膜被定位成使得膜片的内表面在框架的近端和框架的远端之间延伸，并且位于框架的外侧表面的径向外侧。 在至少一个实施方案中，膜片在所有连接点处的布置完全是外框/外框，使得膜片的外表面的一部分不接触框架。

    METHOD AND APPARATUS FOR THE ENDOLUMINAL DELIVERY OF INTRAVASCULAR DEVICES
    5.
    发明申请
    METHOD AND APPARATUS FOR THE ENDOLUMINAL DELIVERY OF INTRAVASCULAR DEVICES 有权
    血管内皮细胞移植的方法和装置

    公开(公告)号：US20120078343A1

    公开(公告)日：2012-03-29

    申请号：US13171400

    申请日：2011-06-28

    申请人： R. David FISH

    发明人： R. David FISH

    IPC分类号： A61F2/84

    CPC分类号： A61F2/958 ,  A61F2/962 ,  A61M25/0074 ,  A61M2025/0058 ,  A61M2025/0175 ,  A61M2025/1081

    摘要： A dual-balloon delivery catheter system includes a carrier segment that is a lead/carrier balloon or mandrel at a distal portion of a catheter. The carrier segment is sequentially arrayed with a more proximally positioned delivery segment, wherein the delivery segment is a delivery balloon or mandrel. The first carrier segment expands the stent-valve a sufficient amount to receive the delivery segment after the carrier segment is moved away from the sent-valve. The delivery segment is then positioned at the target site and the stent-valve is then deployed.

    摘要翻译： 双球囊递送导管系统包括作为导管远端部分处的引导/载体球囊或心轴的载体片段。 载体片段依次排列有较近端定位的递送片段，其中递送片段是递送球囊或心轴。 第一载体段在载体段从传递阀移开之后使支架瓣膨胀足够的量以接收输送段。 然后将输送段定位在目标位置，然后展开支架瓣膜。