公开(公告)号：US08415354B2

公开(公告)日：2013-04-09

申请号：US12390329

申请日：2009-02-20

申请人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Steven Fung ,  Peer B. Jacobson ,  Lynne E. Rueter ,  Marina I. Strakhova ,  Jiahong Wang ,  James T. Link ,  Yixian Chen ,  Hwan-soo Jae ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Qi Shuai ,  Bryan K. Sorensen ,  Martin Winn ,  Dariusz Wodka ,  Hong Yong

发明人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Steven Fung ,  Peer B. Jacobson ,  Lynne E. Rueter ,  Marina I. Strakhova ,  Jiahong Wang ,  James T. Link ,  Yixian Chen ,  Hwan-soo Jae ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Qi Shuai ,  Bryan K. Sorensen ,  Martin Winn ,  Dariusz Wodka ,  Hong Yong

IPC分类号： A61K31/65 ,  A61K31/445 ,  A61K31/496 ,  C07C233/05 ,  C07D211/00 ,  C07D401/04

CPC分类号： C07D295/155 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/55 ,  C07D205/04 ,  C07D207/12 ,  C07D209/44 ,  C07D211/42 ,  C07D213/72 ,  C07D231/12 ,  C07D239/42 ,  C07D277/82 ,  C07D295/125 ,  C07D307/68 ,  C07D401/04 ,  C07D401/12 ,  C07D413/12 ,  C07D487/04 ,  C07D491/056

摘要： The present invention relates to inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

公开(公告)号：US20090192141A1

公开(公告)日：2009-07-30

申请号：US12390329

申请日：2009-02-20

申请人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Steven Fung ,  Peer B. Jacobson ,  Lynne E. Rueter ,  Marina I. Strakhova ,  Jiahong Wang ,  James T. Link ,  Yixian Chen ,  Hwan-soo Jae ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Qi Shuai ,  Bryan K. Sorensen ,  Martin Winn ,  Dariusz Wodka ,  Hong Yong

发明人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Steven Fung ,  Peer B. Jacobson ,  Lynne E. Rueter ,  Marina I. Strakhova ,  Jiahong Wang ,  James T. Link ,  Yixian Chen ,  Hwan-soo Jae ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Qi Shuai ,  Bryan K. Sorensen ,  Martin Winn ,  Dariusz Wodka ,  Hong Yong

IPC分类号： A61K31/55 ,  C07D401/02 ,  A61K31/496 ,  A61K31/5375 ,  C07D295/00 ,  C07D223/16 ,  A61P25/24

CPC分类号： C07D295/155 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/55 ,  C07D205/04 ,  C07D207/12 ,  C07D209/44 ,  C07D211/42 ,  C07D213/72 ,  C07D231/12 ,  C07D239/42 ,  C07D277/82 ,  C07D295/125 ,  C07D307/68 ,  C07D401/04 ,  C07D401/12 ,  C07D413/12 ,  C07D487/04 ,  C07D491/056

摘要： The present invention relates to inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

摘要翻译： 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖，脂质障碍，代谢综合征，中枢神经系统疾病和疾病和病症中的用途 这与过量的糖皮质激素有关。

公开(公告)号：US08940902B2

公开(公告)日：2015-01-27

申请号：US13554698

申请日：2012-07-20

申请人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Yixian Chen ,  Jurgen Dinges ,  Karla Drescher ,  Peer Jacobson ,  Hwan-soo Jae ,  Ravi Kurukulasuriya ,  James T. Link ,  David J. Madar ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Lynne E. Rueter ,  Qi Shuai ,  Bryan K. Sorensen ,  Jiahong Wang ,  Karsten M. Wicke ,  Martin Winn ,  Dariusz Wodka ,  Vince Yeh ,  Hong Yong

发明人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Yixian Chen ,  Jurgen Dinges ,  Karla Drescher ,  Peer Jacobson ,  Hwan-soo Jae ,  Ravi Kurukulasuriya ,  James T. Link ,  David J. Madar ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Lynne E. Rueter ,  Qi Shuai ,  Bryan K. Sorensen ,  Jiahong Wang ,  Karsten M. Wicke ,  Martin Winn ,  Dariusz Wodka ,  Vince Yeh ,  Hong Yong

IPC分类号： C07D211/74 ,  A61K31/44 ,  A61K31/495

CPC分类号： C07D403/12 ,  A61K31/44 ,  A61K31/495 ,  C07D207/267 ,  C07D401/12 ,  C07D401/14

摘要： A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.

摘要翻译： 一种治疗患有与老化和神经变性相关的糖尿病中枢神经系统紊乱和缺陷的患者的方法，包括注意力缺陷障碍，注意力缺陷多动障碍（ADHD），阿尔茨海默病（AD），轻度认知障碍 老年性痴呆，艾滋病痴呆，神经退行性疾病，抑郁症和精神分裂症，包括向需要这种治疗的患者施用有效量的11-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。

公开(公告)号：US20090054426A1

公开(公告)日：2009-02-26

申请号：US12195937

申请日：2008-08-21

申请人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Yixian Chen ,  Jurgen Dinges ,  Karla Drescher ,  Peer Jacobson ,  Hwan-soo Jae ,  Ravi Kurukulasuriya ,  James T. Link ,  David J. Madar ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Lynne E. Rueter ,  Qi Shuai ,  Bryan K. Sorensen ,  Jiahong Wang ,  Karsten M. Wicke ,  Martin Winn ,  Dariusz Wodka ,  Vince Yeh ,  Hong Yong

发明人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Yixian Chen ,  Jurgen Dinges ,  Karla Drescher ,  Peer Jacobson ,  Hwan-soo Jae ,  Ravi Kurukulasuriya ,  James T. Link ,  David J. Madar ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Lynne E. Rueter ,  Qi Shuai ,  Bryan K. Sorensen ,  Jiahong Wang ,  Karsten M. Wicke ,  Martin Winn ,  Dariusz Wodka ,  Vince Yeh ,  Hong Yong

IPC分类号： A61K31/496 ,  A61P25/00 ,  A61K31/5375 ,  A61K31/445 ,  A61K31/16

CPC分类号： C07D403/12 ,  A61K31/44 ,  A61K31/495 ,  C07D207/267 ,  C07D401/12 ,  C07D401/14

摘要： A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.

摘要翻译： 一种治疗患有与老化和神经变性相关的糖尿病中枢神经系统紊乱和缺陷的患者的方法，包括注意力缺陷障碍，注意力缺陷多动障碍（ADHD），阿尔茨海默病（AD），轻度认知障碍 老年性痴呆，艾滋病痴呆，神经变性，抑郁和精神分裂症，包括向需要这种治疗的患者施用有效量的11-β-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。

公开(公告)号：US20130059829A1

公开(公告)日：2013-03-07

申请号：US13554698

申请日：2012-07-20

申请人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Yixian Chen ,  Jurgen Dinges ,  Karla Drescher ,  Peer Jacobson ,  Hwan-soo Jae ,  Ravi Kurukulasuriya ,  James T. Link ,  David J. Madar ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Lynne E. Rueter ,  Qi Shuai ,  Bryan K. Sorensen ,  Jiahong Wang ,  Karsten M. Wicke ,  Martin Winn ,  Dariusz Wodka ,  Vince Yeh ,  Hong Yong

发明人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Yixian Chen ,  Jurgen Dinges ,  Karla Drescher ,  Peer Jacobson ,  Hwan-soo Jae ,  Ravi Kurukulasuriya ,  James T. Link ,  David J. Madar ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Lynne E. Rueter ,  Qi Shuai ,  Bryan K. Sorensen ,  Jiahong Wang ,  Karsten M. Wicke ,  Martin Winn ,  Dariusz Wodka ,  Vince Yeh ,  Hong Yong

IPC分类号： A61K31/5375 ,  A61K31/55 ,  A61K31/551 ,  A61K31/397 ,  A61K31/16 ,  A61P25/28 ,  A61P25/24 ,  A61P25/18 ,  A61P25/22 ,  A61K31/496 ,  A61P25/00

CPC分类号： C07D403/12 ,  A61K31/44 ,  A61K31/495 ,  C07D207/267 ,  C07D401/12 ,  C07D401/14

摘要： A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.

公开(公告)号：US20100152179A9

公开(公告)日：2010-06-17

申请号：US12195937

申请日：2008-08-21

申请人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Yixian Chen ,  Jurgen Dinges ,  Karla Drescher ,  Peer Jacobson ,  Hwan-soo Jae ,  Ravi Kurukulasuriya ,  James T. Link ,  David J. Madar ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Lynne E. Rueter ,  Qi Shuai ,  Bryan K. Sorensen ,  Jiahong Wang ,  Karsten M. Wicke ,  Martin Winn ,  Dariusz Wodka ,  Vince Yeh ,  Hong Yong

发明人： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Yixian Chen ,  Jurgen Dinges ,  Karla Drescher ,  Peer Jacobson ,  Hwan-soo Jae ,  Ravi Kurukulasuriya ,  James T. Link ,  David J. Madar ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Lynne E. Rueter ,  Qi Shuai ,  Bryan K. Sorensen ,  Jiahong Wang ,  Karsten M. Wicke ,  Martin Winn ,  Dariusz Wodka ,  Vince Yeh ,  Hong Yong

IPC分类号： A61K31/496 ,  A61P25/00 ,  A61K31/5375 ,  A61K31/445 ,  A61K31/16

CPC分类号： C07D403/12 ,  A61K31/44 ,  A61K31/495 ,  C07D207/267 ,  C07D401/12 ,  C07D401/14

摘要： A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.

摘要翻译： 一种治疗患有与老化和神经变性相关的糖尿病中枢神经系统紊乱和缺陷的患者的方法，包括注意力缺陷障碍，注意力缺陷多动障碍（ADHD），阿尔茨海默病（AD），轻度认知障碍 老年性痴呆，艾滋病痴呆，神经退行性疾病，抑郁症和精神分裂症，包括向需要这种治疗的患者施用有效量的11-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。

公开(公告)号：US07880001B2

公开(公告)日：2011-02-01

申请号：US11119022

申请日：2005-04-29

申请人： James T. Link ,  Yixian Chen ,  Hwan-Soo Jae ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Qi Shuai ,  Bryan K. Sorensen ,  Martin Winn ,  Dariusz Wodka ,  Hong Yong

发明人： James T. Link ,  Yixian Chen ,  Hwan-Soo Jae ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Qi Shuai ,  Bryan K. Sorensen ,  Martin Winn ,  Dariusz Wodka ,  Hong Yong

IPC分类号： A61K31/496 ,  C07D401/04

CPC分类号： C07D213/75 ,  C07D205/04 ,  C07D207/12 ,  C07D209/44 ,  C07D211/42 ,  C07D231/12 ,  C07D239/42 ,  C07D277/82 ,  C07D295/14 ,  C07D307/68 ,  C07D403/12 ,  C07D413/12 ,  C07D487/18 ,  C07D491/056

摘要： The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions that are mediated by excessive glucocorticoid action.

摘要翻译： 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。 本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征以及其它疾病和病症的用途 由过度的糖皮质激素作用介导。

公开(公告)号：US20050277647A1

公开(公告)日：2005-12-15

申请号：US11119022

申请日：2005-04-29

申请人： James Link ,  Yixian Chen ,  Hwan-Soo Jae ,  Jyoti Patel ,  Marina Pliushchev ,  Jeffrey Rohde ,  Qi Shuai ,  Bryan Sorensen ,  Martin Winn ,  Dariusz Wodka ,  Hong Yong

发明人： James Link ,  Yixian Chen ,  Hwan-Soo Jae ,  Jyoti Patel ,  Marina Pliushchev ,  Jeffrey Rohde ,  Qi Shuai ,  Bryan Sorensen ,  Martin Winn ,  Dariusz Wodka ,  Hong Yong

IPC分类号： A61K31/495 ,  C07D241/04

CPC分类号： C07D213/75 ,  C07D205/04 ,  C07D207/12 ,  C07D209/44 ,  C07D211/42 ,  C07D231/12 ,  C07D239/42 ,  C07D277/82 ,  C07D295/14 ,  C07D307/68 ,  C07D403/12 ,  C07D413/12 ,  C07D487/18 ,  C07D491/056

摘要： The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions that are mediated by excessive glucocorticoid action.

公开(公告)号：US08866397B2

公开(公告)日：2014-10-21

申请号：US13338979

申请日：2011-12-28

申请人： Xu Liu ,  Yixian Chen ,  Shizhou Qiu

发明人： Xu Liu ,  Yixian Chen ,  Shizhou Qiu

IPC分类号： H05B39/02 ,  H01M10/48 ,  H01M2/02 ,  H01M10/42

CPC分类号： H01M2/022 ,  H01M10/425 ,  H01M10/488 ,  Y02E60/12

摘要： A lighting battery relates to a cylindrical rechargeable battery. The lighting battery comprises a battery body, a driving circuit, a switch and light-emitting diodes, wherein the switch is an inching switch, and the driving circuit has a trigger pin which is connected to the switch whereby a trigger signal is acquired to control the driving circuit operate or stop. The power pin and grounding pin of the driving circuit is respectively connected to the positive pole and the negative pole of the battery body, as well as the output pin of the driving circuit is connected to the light-emitting diodes.

摘要翻译： 照明电池与圆柱形可充电电池相关。 照明电池包括电池体，驱动电路，开关和发光二极管，其中开关是微动开关，并且驱动电路具有连接到开关的触发引脚，由此获取触发信号以控制 驱动电路运行或停止。 驱动电路的电源引脚和接地引脚分别连接到电池体的正极和负极，驱动电路的输出引脚连接到发光二极管。