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1.
公开(公告)号:US20120289512A1
公开(公告)日:2012-11-15
申请号:US13469021
申请日:2012-05-10
申请人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
发明人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
IPC分类号: A61K31/165 , A61K31/381 , A61K31/451 , A61K31/4015 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/498 , A61P25/00 , A61P25/28 , A61P25/18 , A61P3/00 , A61P5/46 , A61P3/10 , A61P3/04 , A61P9/12 , A61P25/22 , A61P25/24 , A61K31/4418
CPC分类号: A61K31/498 , A61K31/165 , A61K31/195 , A61K31/196 , A61K31/381 , A61K31/4015 , A61K31/415 , A61K31/44 , A61K31/4409 , A61K31/45 , A61K31/451 , A61K31/5377 , C07C233/11 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C311/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D207/277 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
摘要: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
摘要翻译: 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病,胰岛素抵抗,肥胖症,脂质障碍,代谢综合征,中枢神经系统疾病和疾病中的用途,以及 与过量糖皮质激素有关的病症。
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2.
公开(公告)号:US08993632B2
公开(公告)日:2015-03-31
申请号:US13469021
申请日:2012-05-10
申请人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
发明人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
IPC分类号: A61K31/16 , C07C233/11 , A61K31/165 , A61K31/195 , A61K31/44 , A61K31/45 , A61K31/5377 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C311/46 , C07D207/277 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
CPC分类号: A61K31/498 , A61K31/165 , A61K31/195 , A61K31/196 , A61K31/381 , A61K31/4015 , A61K31/415 , A61K31/44 , A61K31/4409 , A61K31/45 , A61K31/451 , A61K31/5377 , C07C233/11 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C311/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D207/277 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
摘要: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
摘要翻译: 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病,胰岛素抵抗,肥胖症,脂质障碍,代谢综合征,中枢神经系统疾病和疾病中的用途,以及 与过量糖皮质激素有关的病症。
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3.
公开(公告)号:US08198331B2
公开(公告)日:2012-06-12
申请号:US12390286
申请日:2009-02-20
申请人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
发明人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
IPC分类号: A61K31/16
CPC分类号: A61K31/498 , A61K31/165 , A61K31/195 , A61K31/196 , A61K31/381 , A61K31/4015 , A61K31/415 , A61K31/44 , A61K31/4409 , A61K31/45 , A61K31/451 , A61K31/5377 , C07C233/11 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C311/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D207/277 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
摘要: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
摘要翻译: 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病,胰岛素抵抗,肥胖症,脂质障碍,代谢综合征,中枢神经系统疾病和疾病中的用途,以及 与过量糖皮质激素有关的病症。
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公开(公告)号:US20090176783A1
公开(公告)日:2009-07-09
申请号:US12390286
申请日:2009-02-20
申请人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven X. Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
发明人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven X. Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
IPC分类号: A61K31/5377 , A61P3/10 , A61K31/195 , A61K31/165 , A61K31/44 , A61K31/45
CPC分类号: A61K31/498 , A61K31/165 , A61K31/195 , A61K31/196 , A61K31/381 , A61K31/4015 , A61K31/415 , A61K31/44 , A61K31/4409 , A61K31/45 , A61K31/451 , A61K31/5377 , C07C233/11 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C311/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D207/277 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
摘要: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
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公开(公告)号:US20150065508A1
公开(公告)日:2015-03-05
申请号:US14226615
申请日:2014-03-26
申请人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
发明人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
IPC分类号: C07C235/14 , C07C235/22 , C07C271/28 , C07D295/088 , C07D207/48 , C07D257/04 , C07D401/04 , C07D261/08 , C07C237/24 , C07C311/46
CPC分类号: C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04
摘要: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
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6.
公开(公告)号:US08716345B2
公开(公告)日:2014-05-06
申请号:US13530422
申请日:2012-06-22
申请人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
发明人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
IPC分类号: A61K31/16 , C07C239/00
CPC分类号: C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04
摘要: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
摘要翻译: 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病,胰岛素抵抗,肥胖症,脂质障碍,代谢综合征,中枢神经系统疾病和疾病中的用途,以及 与过量糖皮质激素有关的病症。
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公开(公告)号:US20130045978A1
公开(公告)日:2013-02-21
申请号:US13530422
申请日:2012-06-22
申请人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
发明人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
IPC分类号: A61K31/16 , A61K31/196 , A61K31/27 , A61K31/44 , A61K31/277 , A61K31/41 , A61K31/4439 , A61K31/5375 , A61P3/10 , A61P3/04 , A61P3/00 , A61P9/12 , A61P25/28 , A61P25/24 , A61P25/22 , A61P25/18 , A61K31/165
CPC分类号: C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04
摘要: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
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8.
公开(公告)号:US20090192198A1
公开(公告)日:2009-07-30
申请号:US12390318
申请日:2009-02-20
申请人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
发明人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
IPC分类号: A61K31/4439 , A61K31/19 , A61P35/00 , A61K31/165
CPC分类号: C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04
摘要: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
摘要翻译: 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病,胰岛素抵抗,肥胖症,脂质障碍,代谢综合征,中枢神经系统疾病和疾病中的用途,以及 与过量糖皮质激素有关的病症。
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9.
公开(公告)号:US07528282B2
公开(公告)日:2009-05-05
申请号:US11733636
申请日:2007-04-10
申请人: Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
发明人: Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
IPC分类号: C07C237/28
CPC分类号: C07D207/277 , C07C233/11 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
摘要: The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme, The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
摘要翻译: 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶的抑制剂的化合物。本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖型 2型糖尿病,胰岛素抵抗,肥胖,脂质障碍,代谢综合征以及由过度糖皮质激素作用介导的其他疾病和病症。
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10.
公开(公告)号:US07217838B2
公开(公告)日:2007-05-15
申请号:US11326277
申请日:2006-01-05
申请人: Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
发明人: Jeffrey J. Rohde , Qi Shuai , James T. Link , Jyoti R. Patel , Jurgen Dinges , Bryan K. Sorensen , Hong Yong , Vince S. Yeh , Ravi Kurukulasuriya
IPC分类号: C07C233/57 , C07C233/64
CPC分类号: C07D207/277 , C07C233/11 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
摘要: The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
摘要翻译: 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶的抑制剂的化合物。 本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病,胰岛素抵抗,肥胖症,脂质障碍,代谢综合征和其他介导的疾病和病症的用途 由过度的糖皮质激素作用。
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