公开(公告)号：US20150290298A1

公开(公告)日：2015-10-15

申请号：US14442731

申请日：2013-11-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Henn Benkler ,  Daniel Offen

IPC: A61K38/44 ,  A61K45/06 ,  A61K38/17

CPC classification number: A61K38/44 ,  A01K2227/105 ,  A01K2267/0318 ,  A61K38/1709 ,  A61K38/43 ,  A61K45/06 ,  A61K48/00 ,  A61K48/005 ,  C12N2740/15043 ,  C12Y104/01003

Abstract: A method of treating a disease selected from the group consisting of emphysema, sepsis, septic shock, ischemic injury, cerebral ischemia, a neurodegenerative disorder, meningitis, encephalitis, hemorrhage, cerebral ischemia, heart ischemia and a cognitive deficit in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a combination of at least two agents, wherein a first of said two agents upregulates an activity and/or expression of Nrf2 and a second of said two agents is a glutamatergic modulator, thereby treating the disease.

Abstract translation: 一种在有需要的受试者中治疗选自肺气肿，败血症，败血症休克，缺血性损伤，脑缺血，神经变性疾病，脑膜炎，脑炎，出血，脑缺血，心脏缺血和认知缺陷的疾病的方法 被提供。 所述方法包括向受试者施用治疗有效量的至少两种试剂的组合，其中所述两种试剂中的第一种上调Nrf2的活性和/或表达，所述两种试剂中的第二种是谷氨酸能调节剂，由此处理 这种病。