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公开(公告)号：US20180223280A1
公开(公告)日：2018-08-09
申请号：US15749638
申请日：2016-10-21
Applicant: RENA THERAPEUTICS INC.
Inventor： Junichi YANO , Kazuaki TANIGAWARA , Takanori YOKOTA , Kotaro YOSHIOKA
IPC: C12N15/113
CPC classification number: C12N15/113 , A61K31/713 , A61K48/00 , C12N15/09 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322
Abstract: Provided is a nucleic acid complex, preferably a double-stranded nucleic acid complex, having an excellent effect of suppressing the expression of a target gene. Further provided is a nucleic acid complex, that is, a double-stranded nucleic acid complex, comprising an active moiety comprising an antisense nucleic acid complementary to a transcript, for example, a transcript of a target gene, and a carrier moiety comprising a nucleic acid comprising DNA, preferably a DNA-based nucleic acid, which is complementary to the above-described nucleic acid.
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公开(公告)号：US20180228830A1
公开(公告)日：2018-08-16
申请号：US15749831
申请日：2016-10-21
Applicant: RENA THERAPEUTICS INC.
Inventor： Junichi YANO , Kazuaki TANIGAWARA , Takanori YOKOTA , Kotaro YOSHIOKA
IPC: A61K31/7105 , C12N15/113 , A61K47/26
CPC classification number: A61K31/7105 , A61K31/20 , A61K31/223 , A61K31/355 , A61K31/519 , A61K31/713 , A61K47/26 , A61K48/0075 , C12N15/09 , C12N15/113 , C12N2310/11 , C12N2310/313 , C12N2310/321 , C12N2310/3231 , C12N2310/35 , C12N2310/50
Abstract: [Problem to be Solved ] Provided is a nucleic acid complex, preferably a double-stranded nucleic acid complex, having an excellent effect of suppressing the expression of a target gene.[Solution] The problem is solved by using a nucleic acid complex, preferably a double-stranded nucleic acid complex, comprising an active moiety comprising an antisense nucleic acid complementary to a transcript, for example, a transcript of a target gene, and a carrier moiety comprising a nucleic acid complementary to the nucleic acid, and having at least one bulge structure.[Selected Drawing] None
