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9 条记录 (耗时 0.032 秒)

    Real-time, single-step bioassay using nanoplasmonic resonator with ultra-high sensitivity
    2.
    发明授权
    Real-time, single-step bioassay using nanoplasmonic resonator with ultra-high sensitivity 有权
    使用具有超高灵敏度的纳米级谐振器进行实时，单步生物测定

    公开(公告)号：US08685743B2

    公开(公告)日：2014-04-01

    申请号：US12772118

    申请日：2010-04-30

    申请人： Xiang Zhang ,  Jonathan A. Ellman ,  Fanqing Frank Chen ,  Kai-Hang Su ,  Qi-Huo Wei ,  Cheng Sun

    发明人： Xiang Zhang ,  Jonathan A. Ellman ,  Fanqing Frank Chen ,  Kai-Hang Su ,  Qi-Huo Wei ,  Cheng Sun

    IPC分类号： G01N21/00

    CPC分类号： G01N21/658 ,  B82Y15/00 ,  B82Y20/00 ,  C12Q1/37

    摘要： A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.

    摘要翻译： 纳米等离子体共振器（NPR）包括具有交替屏蔽层的金属纳米盘，其具有缀合或连接到纳米塑料谐振器表面的标记生物分子，用于酶活性的高度灵敏测量。 NPR以高度可重复的方式增强拉曼信号，能够以皮摩尔敏感度水平实时快速检测蛋白酶和酶活性，如前列腺特异抗原（paPSA）。 来自paPSA阳性细胞的细胞外液（ECF）的实验在非常小的样品体积中在实时单步检测中在复杂的生物流体背景中表现出特异性检测。

    Lithography apparatus and method employing non-environmental variable correction
    3.
    发明申请
    Lithography apparatus and method employing non-environmental variable correction 失效
    使用非环境变量校正的光刻设备和方法

    公开(公告)号：US20050037266A1

    公开(公告)日：2005-02-17

    申请号：US10639967

    申请日：2003-08-12

    申请人： Fei Tsai ,  Chun-Lang Chen ,  Cheng Sun

    发明人： Fei Tsai ,  Chun-Lang Chen ,  Cheng Sun

    IPC分类号： G03F7/20 ,  G06F17/50

    CPC分类号： G03F1/78 ,  G03F1/36 ,  G03F1/68 ,  G03F7/70558

    摘要： A lithographic apparatus for forming a patterned resist layer and a method for forming a microelectronic product both employ a lithographic exposure tool controller designed to: (1) receive input data for at least one non-environmental variable that influences an exposure dose when forming a patterned resist layer from a blanket resist layer while employing a lithographic exposure tool; and (2) determine the exposure dose for forming the patterned resist layer from the blanket resist layer while employing the input data. The apparatus and method provide for forming the microelectronic product with enhanced dimensional control.

    摘要翻译： 用于形成图案化抗蚀剂层的光刻设备和用于形成微电子产品的方法都采用平版印刷曝光工具控制器，其设计成：（1）接收至少一个影响曝光剂量的非环境变量的输入数据， 使用光刻曝光工具从抗蚀剂层获得抗蚀剂层; 和（2）在采用输入数据的同时确定用于从橡皮布抗蚀剂层形成图案化抗蚀剂层的曝光剂量。 该装置和方法提供了用增强的尺寸控制形成微电子产品。

    WELDING SYSTEM AND METHOD FOR AUTOMATIC WELDING
    4.
    发明申请
    WELDING SYSTEM AND METHOD FOR AUTOMATIC WELDING 审中-公开
    焊接系统及自动焊接方法

    公开(公告)号：US20140008415A1

    公开(公告)日：2014-01-09

    申请号：US13562787

    申请日：2012-07-31

    申请人： Hongyuan Shen ,  Peng Li ,  Tingting Yang ,  Yuanbiao Wu ,  Zhixue Peng ,  Cheng Sun ,  Attila Szabo ,  Meilong Li

    发明人： Hongyuan Shen ,  Peng Li ,  Tingting Yang ,  Yuanbiao Wu ,  Zhixue Peng ,  Cheng Sun ,  Attila Szabo ,  Meilong Li

    IPC分类号： B23K3/00

    CPC分类号： B23K9/0216 ,  B23K9/0956 ,  B23K9/126

    摘要： A welding system for automatically welding a welding seam includes a welding arm, a sensor and a controller. The controller includes a welding seam contour detection component, a welding seam contour calculation component, a welding trajectory point calculation component, and a welding parameter setting component. The welding seam contour detection component is used for detecting an initial welding seam contour and detecting remaining welding seam contours after welding each layer of the welding seam. The welding seam contour calculation component is used for calculating the detected welding seam contours. The welding trajectory point calculation component is used for calculating welding trajectory points based on the calculated welding seam contours. The welding parameter setting component is used for setting welding parameters based on the calculated welding seam contours and the calculated welding trajectory points.

    摘要翻译： 用于自动焊接焊缝的焊接系统包括焊接臂，传感器和控制器。 控制器包括焊缝轮廓检测部件，焊缝轮廓计算部件，焊接轨迹点计算部件和焊接参数设定部件。 焊缝轮廓检测部件用于检测初始焊缝轮廓，并在焊接每层焊缝之后检测剩余焊缝轮廓。 焊缝轮廓计算组件用于计算检测到的焊缝轮廓。 焊接轨迹点计算组件用于根据计算的焊缝轮廓计算焊接轨迹点。 焊接参数设置组件用于根据计算的焊缝轮廓和计算的焊接轨迹点设置焊接参数。

    Method and system for analyzing semiconductor fabrication
    6.
    发明申请
    Method and system for analyzing semiconductor fabrication 失效
    分析半导体制造的方法和系统

    公开(公告)号：US20050075750A1

    公开(公告)日：2005-04-07

    申请号：US10677929

    申请日：2003-10-02

    申请人： Cheng Sun

    发明人： Cheng Sun

    IPC分类号： G06F19/00 ,  H01L21/00 ,  H01L21/31 ,  H01L21/66

    CPC分类号： H01L22/20

    摘要： A method and a system for analyzing a semiconductor manufacturing process includes a semiconductor manufacturing process that can generate sets of input and output data. Principal components are generated from the set of input data, and a set of principal component score data are determined based on the principal components. A relationship between the sets of input and output data is determined from the principal component score data and the output data. The system includes at least one storage device and a processor. The storage device stores input data and output data from the semiconductor manufacturing process. The processor is coupled to the storage device. The processor determines principal components from the input data, a set of principal component score data based on the principal components, and a relationship between the input and output data from the principal component score data and the output data.

    摘要翻译： 用于分析半导体制造工艺的方法和系统包括可以产生一组输入和输出数据的半导体制造工艺。 主要成分是从该组输入数据生成的，并且基于主成分确定一组主成分分数数据。 根据主成分分数数据和输出数据确定输入和输出数据组之间的关系。 该系统包括至少一个存储设备和处理器。 存储装置存储来自半导体制造过程的输入数据和输出数据。 处理器耦合到存储设备。 处理器根据主要成分确定来自输入数据的主成分，一组主成分分数数据，以及来自主成分分数数据和输出数据的输入和输出数据之间的关系。

    Time resolved single-step protease activity quantification using nanoplasmonic resonator (NPR) sensor
    8.
    发明申请
    Time resolved single-step protease activity quantification using nanoplasmonic resonator (NPR) sensor 有权
    使用纳米弹性共振器（NPR）传感器的时间分辨单步蛋白酶活性定量

    公开(公告)号：US20110058164A1

    公开(公告)日：2011-03-10

    申请号：US12772118

    申请日：2010-04-30

    申请人： Xiang Zhang ,  Jonathan A. Ellman ,  Fanqing Frank Chen ,  Cheng Sun ,  Kai-Hang Su ,  Qi-Huo Wei

    发明人： Xiang Zhang ,  Jonathan A. Ellman ,  Fanqing Frank Chen ,  Cheng Sun ,  Kai-Hang Su ,  Qi-Huo Wei

    IPC分类号： G01J3/44

    CPC分类号： G01N21/658 ,  B82Y15/00 ,  B82Y20/00 ,  C12Q1/37

    摘要： A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.

    摘要翻译： 纳米等离子体共振器（NPR）包括具有交替屏蔽层的金属纳米盘，其具有缀合或连接到纳米塑料谐振器表面的标记生物分子，用于酶活性的高度灵敏测量。 NPR以高度可重复的方式增强拉曼信号，能够以皮摩尔敏感度水平实时快速检测蛋白酶和酶活性，如前列腺特异抗原（paPSA）。 来自paPSA阳性细胞的细胞外液（ECF）的实验在非常小的样品体积中在实时单步检测中在复杂的生物流体背景中表现出特异性检测。

    OPTICAL PLATFORM FOR SIMULTANEOUSLY STIMULATING, MANIPULATING, AND PROBING MULTIPLE LIVING CELLS IN COMPLEX BIOLOGICAL SYSTEMS
    9.
    发明申请
    OPTICAL PLATFORM FOR SIMULTANEOUSLY STIMULATING, MANIPULATING, AND PROBING MULTIPLE LIVING CELLS IN COMPLEX BIOLOGICAL SYSTEMS 审中-公开
    用于同时刺激，操纵和探索复杂生物系统中多种生命细胞的光学平台

    公开(公告)号：US20100292931A1

    公开(公告)日：2010-11-18

    申请号：US12774856

    申请日：2010-05-06

    申请人： Sheng Wang ,  Cheng Sun ,  Xiang Zhang

    发明人： Sheng Wang ,  Cheng Sun ,  Xiang Zhang

    IPC分类号： G06F19/00 ,  G01N21/00

    CPC分类号： G01N21/6458 ,  G01N21/6408 ,  G01N2201/0627 ,  G01N2201/0675

    摘要： An optical platform and system for the simultaneous stimulation, manipulation and probing of multiple living cells in complex biological systems. The apparatus utilizes a spatiotemporal light modulator to expose a sample to pinpoints of light at selected times and wavelengths in two or three dimensional space and then detect the responses. In one embodiment, a spatiotemporal light modulator is optically coupled to a variable wavelength light source, a lens system and a system control unit with sample response sensors, wherein sample responses are detected after exposure to patterns of light in real time. Light patterns can be modulated in response to sample responses.

    摘要翻译： 用于在复杂生物系统中同时刺激，操纵和探测多个活细胞的光学平台和系统。 该装置利用时空光调制器将样品暴露于两维或三维空间中选定时间和波长处的光的精确点，然后检测响应。 在一个实施例中，时空光调制器与可变波长光源，透镜系统和具有采样响应传感器的系统控制单元光学耦合，其中在曝光到实际图案之后检测样本响应。 光图案可以响应于样品响应进行调制。