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公开(公告)号:US07935702B2
公开(公告)日:2011-05-03
申请号:US11250135
申请日:2005-10-12
申请人: Rajagopal Bakthavatchalam , Timothy M. Caldwell , Bertrand L. Chenard , Kevin J. Hodgetts , Scott Michael Capitosti
发明人: Rajagopal Bakthavatchalam , Timothy M. Caldwell , Bertrand L. Chenard , Kevin J. Hodgetts , Scott Michael Capitosti
IPC分类号: A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D471/00 , C07D487/00
CPC分类号: C07D471/04 , C07D401/04 , C07D401/12 , C07D401/14
摘要: Substituted biaryl quinolin-4-ylamine analogues of Formula I are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译: 提供式I的取代的联芳基喹啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体,并且特别可用于治疗与人类,驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法,以及使用这些配体进行受体定位研究的方法。