公开(公告)号：US5633426A

公开(公告)日：1997-05-27

申请号：US194717

申请日：1994-02-10

申请人： Reiko Namikawa ,  Seishi Kyoizumi ,  Joseph M. McCune ,  Hideto Kaneshima

发明人： Reiko Namikawa ,  Seishi Kyoizumi ,  Joseph M. McCune ,  Hideto Kaneshima

IPC分类号： A01K67/027 ,  A61K49/00 ,  A61K48/00

CPC分类号： A01K67/0271

摘要： Chimeric immunocompromised hosts are provided, comprising human bone marrow of at least 4 weeks from the time of implantation. The bone marrow is found to assume the normal population of bone marrow except for erythrocytes. The bone marrow may be used to study the effect of various agents on the proliferation and differentiation of hematopoietic cells.

摘要翻译： 提供嵌合的免疫受损宿主，其包含从植入起始至少4周的人骨髓。 除了红细胞外，发现骨髓假定正常骨髓群体。 骨髓可用于研究各种药剂对造血细胞增殖和分化的影响。

公开(公告)号：US5643551A

公开(公告)日：1997-07-01

申请号：US329679

申请日：1994-10-26

申请人： Reiko Namikawa ,  Seishi Kyoizumi ,  Emilya Shtivelman ,  Joseph M. McCune

发明人： Reiko Namikawa ,  Seishi Kyoizumi ,  Emilya Shtivelman ,  Joseph M. McCune

IPC分类号： A01K67/027 ,  A61K35/12 ,  A61K49/00 ,  C12N5/06 ,  C12Q1/02 ,  G01N33/48 ,  A01N57/00 ,  A61K38/00 ,  C12N5/00 ,  C12N15/06

CPC分类号： A01K67/0271 ,  A61K49/0008 ,  Y10S424/90

摘要： A method for initiating metastasis of human tumor cells under experimental conditions is provided. Immunocompromised non-human mammals having a viable, xenogeneic organ or tissue are used as a host for human tumor cells. The cells are introduced into the chimeric animal after the solid tissue is implanted and are then able to grow and metastasize as they would in situ. Therapeutic regimens may be evaluated in this system to determine efficacy against metastatic processes.

摘要翻译： 提供了一种在实验条件下启动人肿瘤细胞转移的方法。 具有活的异种器官或组织的免疫受损的非人哺乳动物用作人肿瘤细胞的宿主。 在植入固体组织后，将细胞导入嵌合动物体内，然后能像原位一样生长和转移。 可以在该系统中评估治疗方案以确定对转移过程的功效。

公开(公告)号：US07067314B2

公开(公告)日：2006-06-27

申请号：US10172986

申请日：2002-06-18

申请人： Takaaki Ohara ,  Kenji Yamashita ,  Tetsu Kakutani ,  Seishi Kyoizumi

发明人： Takaaki Ohara ,  Kenji Yamashita ,  Tetsu Kakutani ,  Seishi Kyoizumi

IPC分类号： C12N5/06 ,  G01N33/543 ,  G07K16/00 ,  C12P21/08

CPC分类号： C07K16/28 ,  C07K14/47 ,  G01N33/56966

摘要： It is an object to utilize a novel HSCA-3 antigen occurring in immature hemopoietic stem cells and a monoclonal antibody recognizing said antigen in 1) the immunoassay or flow cytometry involving antibody labeling and 2) the isolation and purification of immature hemopoietic stem cells from human bone marrow cells, umbilical code blood or blood enriched in human hemopoietic stem cells by mobilization with G-CSF.It is directed to a novel HSCA-3 antigen occurring in immature hemopoietic stem cells and to a monoclonal antibody or an immunoreactive fragment thereof which recognizes said antigen.

摘要翻译： 本发明的目的是利用在未成熟造血干细胞中发生的新型HSCA-3抗原和识别所述抗原的单克隆抗体，1）免疫测定或流式细胞术涉及抗体标记和2）从人类分离和纯化未成熟造血干细胞 骨髓细胞，脐带血或富含人造血干细胞的血液用G-CSF动员。 涉及发生在未成熟造血干细胞中的新型HSCA-3抗原以及识别所述抗原的单克隆抗体或其免疫反应性片段。