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1.发明申请Polymorphisms in the human genes for OCT1 and their use in diagnostic and therapeutic applications 审中-公开OCT1的人类基因的多态性及其在诊断和治疗应用中的应用公开(公告)号：US20090018030A1
公开(公告)日：2009-01-15
申请号：US12221241
申请日：2008-07-30
CPC分类号： C07K14/4702 , A01K2217/05 , A61K38/00 , C12Q1/6883
摘要： The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.
摘要翻译： 本发明涉及多晶型OCT1多核苷酸。 此外，本发明涉及包含本发明的多核苷酸的基因或载体，并涉及用本发明的多核苷酸或基因进行遗传工程改造的宿主细胞。 此外，本发明涉及用于产生分子变体多肽或其片段的方法，用于产生能够表达分子变体多肽的细胞的方法及其由本发明的多核苷酸或基因编码的多肽或其片段，或可由 方法或由本发明方法生产的细胞。 此外，本发明涉及特异性结合本发明多肽的抗体。 此外，本发明涉及转基因非人动物。 本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。 此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。 此外，本发明涉及制备药物组合物的方法和诊断疾病的方法。 此外，本发明涉及本发明的多核苷酸的检测方法。 此外，本发明包括诊断和药物组合物。 更进一步地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。 最后，本发明涉及诊断试剂盒。
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2.发明申请POLYMORPHISMS IN THE HUMAN GENES FOR OCT1 AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 审中-公开OCT1人类基因多态性及其在诊断和治疗应用中的应用公开(公告)号：US20100009366A1
公开(公告)日：2010-01-14
申请号：US12477506
申请日：2009-06-03
CPC分类号： C07K14/4702 , A01K2217/05 , A61K38/00 , C12Q1/6883
摘要： The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.
摘要翻译： 本发明涉及多晶型OCT1多核苷酸。 此外，本发明涉及包含本发明的多核苷酸的基因或载体，并涉及用本发明的多核苷酸或基因进行遗传工程改造的宿主细胞。 此外，本发明涉及用于产生分子变体多肽或其片段的方法，用于产生能够表达分子变体多肽的细胞的方法，以及由本发明的多核苷酸或基因编码的多肽或其片段，或可由 方法或由本发明方法生产的细胞。 此外，本发明涉及特异性结合本发明多肽的抗体。 此外，本发明涉及转基因非人动物。 本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。 此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。 此外，本发明涉及制备药物组合物的方法和诊断疾病的方法。 此外，本发明涉及本发明的多核苷酸的检测方法。 此外，本发明包括诊断和药物组合物。 更进一步地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。 最后，本发明涉及诊断试剂盒。
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3.发明申请Polymorphisms in the human genes for OCT 1 and their use in diagnostic and therapeutic applications 审中-公开OCT 1的人类基因多态性及其在诊断和治疗应用中的应用公开(公告)号：US20090061452A1
公开(公告)日：2009-03-05
申请号：US12221130
申请日：2008-07-30
CPC分类号： C07K14/4702 , A01K2217/05 , A61K38/00 , C12Q1/6883
摘要： The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.
摘要翻译： 本发明涉及多晶型OCT1多核苷酸。 此外，本发明涉及包含本发明的多核苷酸的基因或载体，并涉及用本发明的多核苷酸或基因进行遗传工程改造的宿主细胞。 此外，本发明涉及用于产生分子变体多肽或其片段的方法，用于产生能够表达分子变体多肽的细胞的方法及其由本发明的多核苷酸或基因编码的多肽或其片段，或可由 方法或由本发明方法生产的细胞。 此外，本发明涉及特异性结合本发明多肽的抗体。 此外，本发明涉及转基因非人动物。 本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。 此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。 此外，本发明涉及制备药物组合物的方法和诊断疾病的方法。 此外，本发明涉及本发明的多核苷酸的检测方法。 此外，本发明包括诊断和药物组合物。 更进一步地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。 最后，本发明涉及诊断试剂盒。
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4.发明申请Polymorphisms in the human genes for oct1 and their use in diagnostic and therapeutic applications 审中-公开Oct1的人类基因多态性及其在诊断和治疗应用中的应用公开(公告)号：US20060122372A1
公开(公告)日：2006-06-08
申请号：US10525360
申请日：2003-08-22
IPC分类号： C12Q1/68 , A01K67/027 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/4702 , A01K2217/05 , A61K38/00 , C12Q1/6883
摘要： The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.
摘要翻译： 本发明涉及多晶型OCT1多核苷酸。 此外，本发明涉及包含本发明的多核苷酸的基因或载体，并涉及用本发明的多核苷酸或基因进行遗传工程改造的宿主细胞。 此外，本发明涉及用于产生分子变体多肽或其片段的方法，用于产生能够表达分子变体多肽的细胞的方法及其由本发明的多核苷酸或基因编码的多肽或其片段，或可由 方法或由本发明方法生产的细胞。 此外，本发明涉及特异性结合本发明多肽的抗体。 此外，本发明涉及转基因非人动物。 本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。 此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。 此外，本发明涉及制备药物组合物的方法和诊断疾病的方法。 此外，本发明涉及本发明的多核苷酸的检测方法。 此外，本发明包括诊断和药物组合物。 更进一步地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。 最后，本发明涉及诊断试剂盒。
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公开(公告)号：US07238708B2
公开(公告)日：2007-07-03
申请号：US11078934
申请日：2005-03-10
申请人： Ernest M. Wright , Ana Diez-Sampedro , Bruce A. Hirayama , Hermann Koepsell , Valentin Gorboulev , Christina Osswald
发明人： Ernest M. Wright , Ana Diez-Sampedro , Bruce A. Hirayama , Hermann Koepsell , Valentin Gorboulev , Christina Osswald
IPC分类号： A61K31/445
CPC分类号： A61K31/445
摘要： Methods are provided for the modulation of hSGLT3 protein glucosensor activity. The sensor is expressed in cholinergic neurons that regulate muscle activity, and in tissues including the brain and pacreas. The present invention also provides methods of identifying therapeutic compounds that modify the function of these sensors. Such therapeutic compounds have a functional effect on regulators of muscle activity, including gastrointestinal smooth muscles; on regulation of weight and metabolism; regulation of pancreatic function, including glucagons release; and in taste perception.
摘要翻译： 提供了调节hSGLT3蛋白质葡萄糖传感器活性的方法。 传感器在调节肌肉活动的胆碱能神经元以及包括大脑和太平洋在内的组织中表达。 本发明还提供了鉴定修饰这些传感器功能的治疗化合物的方法。 这些治疗化合物对肌肉活性的调节剂具有功能作用，包括胃肠道平滑肌; 对体重和代谢的调节; 调节胰腺功能，包括胰高血糖素释放; 和味觉。
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公开(公告)号：US20050108782A1
公开(公告)日：2005-05-19
申请号：US10771151
申请日：2004-02-04
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0362 , A61K38/00 , A61K48/00 , C07K14/4702 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： Described is a transgenic non-human RS1−/− animal characterized in that it shows increased body weight, increased total fat and/or increased mean fat cell volume compared to a wild type animal. Also described are various uses of said animal, e.g. as an animal model for adipositas or hypercholesterolaemia, for identifying substances suitable for the therapy and/or prevention of adipositas or hypercholesterolaemia or for assaying the efficacy of dieting or pharmacological therapy of adipositas or hypercholesterolaemia. Finally, the use of compounds is described which are capable of modulating the activity/expression of RS1 for the treatment or prevention of diseases like adipositas or hypercholesterolaemia.
摘要翻译： 描述了一种转基因非人类RS1 - / - 动物，其特征在于与野生型动物相比，其显示体重增加，总脂肪增加和/或增加的平均脂肪细胞体积。 还描述了所述动物的各种用途，例如， 作为用于脂肪或高胆固醇血症的动物模型，用于鉴定适合于治疗和/或预防脂肪或高胆固醇血症的物质或用于测定脂肪或高胆固醇血症的节食或药物治疗的功效。 最后，描述了能够调节RS1的活性/表达以治疗或预防诸如脂肪或高胆固醇血症的疾病的化合物的用途。
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7.发明授权Tripeptides that down regulate the activity of plasma membrane transporters including sodium-D-glucose cotransporter SgIt1 有权降低质膜转运蛋白活性的三肽，包括D-葡萄糖转运蛋白SgIt1公开(公告)号：US09155778B2
公开(公告)日：2015-10-13
申请号：US11910594
申请日：2006-03-31
摘要： A regulatory protein RS1 fragment or a nucleic acid molecule encoding the regulatory protein RS1 fragment for the preparation of a pharmaceutical composition, food and/or food supplements for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, wherein the RS1 fragment is characterized in comprising at least the amino acid sequence Q-C-P Glutamine-Cysteine-Proline) or derivatives thereof, is provided. Also provided is a method for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis comprising administering a pharmaceutically active amount of a regulatory protein RS1 fragment or a nucleic acid molecule encoding a regulatory protein RS1 fragment, wherein the RS1 fragment comprises at least the amino acid sequence Q-C-P or derivatives thereof.
摘要翻译： 编码用于制备药物组合物的调节蛋白RS1片段的调节蛋白RS1片段或核酸分子，用于改善，预防和/或治疗由α受体引起的代谢性疾病或继发性疾病的食物和/或食物补充剂 （病理）体内平衡的修饰，其中RS1片段的特征在于至少包含氨基酸序列QCP谷氨酰胺 - 半胱氨酸 - 脯氨酸）或其衍生物。 还提供了用于改善，预防和/或治疗由体内平衡的（病理）修饰引起的代谢疾病或继发性疾病的方法，其包括施用药学活性量的调节蛋白RS1片段或编码 调节蛋白RS1片段，其中RS1片段至少包含氨基酸序列QCP或其衍生物。
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8.发明授权Transport protein which effects the transport of cationic xenobiotics and/or pharmaceuticals, DNA sequences encoding it and their use 失效影响阳离子异生物和/或药物运输的转运蛋白，编码它的DNA序列及其用途
公开(公告)号：US6063623A
公开(公告)日：2000-05-16
申请号：US501572
申请日：1995-07-12
IPC分类号： C12N15/09 , A61K38/00 , A61K38/16 , A61K39/395 , A61K48/00 , A61P43/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/705 , C12N5/00 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/91
CPC分类号： C07K14/705 , C07K14/47
摘要： A transport protein has been cloned which is present in liver epithelial cells and kidney epithelial cells and in intestinal cells and is responsible for transporting cationic pharmaceuticals and/or xenobiotics. This transport protein has been described more specifically by its DNA and amino acid sequences, and various uses are disclosed which are, in particular, of great importance for developing novel medicaments.
摘要翻译： 已经克隆了转运蛋白，其存在于肝上皮细胞和肾上皮细胞和肠细胞中，并且负责运输阳离子药物和/或异生物。 已经通过其DNA和氨基酸序列更具体地描述了这种转运蛋白质，并且公开了对开发新型药物特别重要的各种用途。
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9.发明申请PEPTIDES THAT DOWN REGULATE THE ACTIVITY OF PLASMA MEMBRANE TRANSPORTERS INCLUDING SODIUM-D-GLUCOSE COTRANSPORTER SGLT1 有权下调调节等离子体膜输送机的活性，包括S-II-D-葡萄糖共聚物SGLT1公开(公告)号：US20120148673A1
公开(公告)日：2012-06-14
申请号：US11910597
申请日：2006-03-31
IPC分类号： A61K9/28 , A61K31/713 , A61K38/08 , A61P3/08 , G01N33/566 , A61P3/00 , A61K38/02 , A61K38/10
CPC分类号： A61K38/08
摘要： The present invention relates to the use of a regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of a pharmaceutical composition for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, wherein said RS1 fragment is characterized in comprising at least 3 consecutive amino acid residues as comprised in the amino acid sequence S-D-S-D-R-I-E-P (Serine-Aspartic acid-Serine-Aspartic acid-Arginine-Isoleucine-Glutamic acid-Proline) (SEQ ID NO: 9) or derivatives thereof. Furthermore, the present invention relates to a method for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, said method comprising administering to a patient in need of such amelioration, prevention and/or treatment a pharmaceutically active amount of said regulatory protein RS1 fragment as defined herein or a nucleic acid molecule encoding said regulatory protein RS1 fragment. Moreover, the present invention relates to the use of said regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of food, feed and/or food supplements.
摘要翻译： 本发明涉及调节蛋白RS1片段或编码所述调节蛋白RS1片段的核酸分子用于制备用于改善，预防和/或治疗由...引起的代谢性疾病或继发性疾病的药物组合物的用途 其中所述RS1片段的特征在于包含氨基酸序列SDSDRIEP（丝氨酸 - 天冬氨酸 - 丝氨酸 - 天冬氨酸 - 精氨酸 - 异亮氨酸 - 谷氨酸 - 脯氨酸）中至少3个连续的氨基酸残基 ）（SEQ ID NO：9）或其衍生物。 此外，本发明涉及一种改善，预防和/或治疗由体内平衡的（病理）修饰引起的代谢性疾病或继发性疾病的方法，所述方法包括对需要这种改善，预防的患者施用 和/或治疗药学活性量的本文定义的所述调节蛋白RS1片段或编码所述调节蛋白RS1片段的核酸分子。 此外，本发明涉及所述调节蛋白RS1片段或编码所述调节蛋白RS1片段的核酸分子用于制备食物，饲料和/或食品补充剂的用途。
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10.发明申请Tripeptides that Down Regulate the Activity of Plasma Membrane transporters Including Sodium-D-Glucose Cotransporter Sglt1 有权降低血浆膜转运蛋白活性的三肽，包括D-葡萄糖转运蛋白Sglt1公开(公告)号：US20090203621A1
公开(公告)日：2009-08-13
申请号：US11910594
申请日：2006-03-31
IPC分类号： A61K38/06 , A61K31/7088 , A61K9/20 , G01N33/68 , G01N33/566
摘要： The present invention relates to the use of a regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of a pharmaceutical composition for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, wherein said RS1 fragment is characterized in comprising at least the amino acid sequence Q-C-P (Glutamine-Cysteine-Proline) or derivatives thereof. Furthermore, the present invention relates to a method for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, said method comprising administering to a patient in need of such amelioration, prevention and/or treatment a pharmaceutically active amount of a regulatory protein RS1 fragment or a nucleic acid molecule encoding a regulatory protein RS1 fragment, wherein said RS1 fragment is characterized in comprising at least the amino acid sequence Q-C-P (Glutamine-Cysteine-Proline) or derivatives thereof. Moreover, the present invention relates to the use of a regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of food and/or food supplements.
摘要翻译： 本发明涉及调节蛋白RS1片段或编码所述调节蛋白RS1片段的核酸分子用于制备用于改善，预防和/或治疗由...引起的代谢性疾病或继发性疾病的药物组合物的用途 其中所述RS1片段的特征在于至少包含氨基酸序列QCP（谷氨酰胺 - 半胱氨酸 - 脯氨酸）或其衍生物。 此外，本发明涉及一种改善，预防和/或治疗由体内平衡的（病理）修饰引起的代谢性疾病或继发性疾病的方法，所述方法包括对需要这种改善，预防的患者施用 和/或治疗药物活性量的编码调节蛋白RS1片段的调节蛋白RS1片段或核酸分子，其中所述RS1片段的特征在于至少包含氨基酸序列QCP（谷氨酰胺 - 半胱氨酸 - 脯氨酸）或衍生物 其中。 此外，本发明涉及调节蛋白RS1片段或编码所述调节蛋白RS1片段的核酸分子用于制备食物和/或食物补充剂的用途。
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