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公开(公告)号：US20070072231A1
公开(公告)日：2007-03-29
申请号：US11603619
申请日：2006-11-22
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/99 , C07K14/525
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US20120156722A1
公开(公告)日：2012-06-21
申请号：US13401978
申请日：2012-02-22
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US08124733B2
公开(公告)日：2012-02-28
申请号：US12888572
申请日：2010-09-23
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US07825220B2
公开(公告)日：2010-11-02
申请号：US12626290
申请日：2009-11-25
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US20110008913A1
公开(公告)日：2011-01-13
申请号：US12888572
申请日：2010-09-23
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
IPC分类号： G01N33/53 , C07K14/435
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US07642070B2
公开(公告)日：2010-01-05
申请号：US11603619
申请日：2006-11-22
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
IPC分类号： C12N15/00
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
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公开(公告)号：US20100112591A1
公开(公告)日：2010-05-06
申请号：US12626290
申请日：2009-11-25
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US07153935B2
公开(公告)日：2006-12-26
申请号：US10045815
申请日：2001-10-26
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
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公开(公告)号：US06949364B2
公开(公告)日：2005-09-27
申请号：US10876841
申请日：2004-06-28
申请人： Takashi Sugihara , Renu Wadhwa , Sunil C. Kaul , Youji Mitsui
发明人： Takashi Sugihara , Renu Wadhwa , Sunil C. Kaul , Youji Mitsui
IPC分类号： C07K14/47 , C12N15/09 , C12N15/12 , C12P21/06 , C12P21/02 , C07H21/04 , C12N5/10 , C12N15/63
CPC分类号： C07K14/4702
摘要： A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis.
摘要翻译： 在研究编码引发细胞死亡的未知蛋白质的基因的表达过程中，已经意外地分离了在睾丸中特异表达的基因。 分离的基因是一个新的基因序列，在数据库中没有显着的同源物。 该基因也被发现参与睾丸分化的调节。
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公开(公告)号：US20050033036A1
公开(公告)日：2005-02-10
申请号：US10876841
申请日：2004-06-28
申请人： Takashi Sugihara , Renu Wadhwa , Sunil Kaul , Youji Mitsui
发明人： Takashi Sugihara , Renu Wadhwa , Sunil Kaul , Youji Mitsui
CPC分类号： C07K14/4702
摘要： A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis.
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