-
公开(公告)号:US06884803B2
公开(公告)日:2005-04-26
申请号:US10307870
申请日:2002-12-02
申请人: Richard Apodaca , Wei Xiao , Jill A. Jablonowski
发明人: Richard Apodaca , Wei Xiao , Jill A. Jablonowski
IPC分类号: C07D295/12 , A61K31/444 , A61K31/4453 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/08 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/28 , A61P27/14 , A61P27/16 , A61P37/08 , A61P43/00 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/66 , C07D213/38 , C07D215/06 , C07D215/12 , C07D239/42 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10 , C07D491/113 , C07D403/06 , A61K31/495 , A61P25/24 , C07D295/04
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/38 , C07D215/06 , C07D273/00 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10
摘要: Disclosed are substituted phenylalkynes of formula (I), wherein R1, R2, R3, R4, R5 and n are as defined, compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 公开了式(I)的取代的苯基炔,其中R 1,R 2,R 3,R 4, R 5和n如上所定义,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
-
公开(公告)号:US07446104B2
公开(公告)日:2008-11-04
申请号:US11874327
申请日:2007-10-18
申请人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
IPC分类号: C07D295/04 , A61K31/54
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 取代的式(I)的苯炔基,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
-
公开(公告)号:US07288540B2
公开(公告)日:2007-10-30
申请号:US11490394
申请日:2006-07-20
申请人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
IPC分类号: C07D413/06 , A61K31/5377
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I) compositions containing them and their methods of use to treat histamine related disorders are described, wherein R1, R2, R3, R4, R5 and n are as defined.
摘要翻译: 描述了含有它们的式(I)的组合物的取代苯炔基及其用于治疗组胺相关病症的方法,其中R 1,R 2,R 3, R 4,R 4,R 5和n如上所定义。
-
公开(公告)号:US07482364B2
公开(公告)日:2009-01-27
申请号:US11874321
申请日:2007-10-18
申请人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
IPC分类号: A61K31/54 , A61K31/445 , C07D239/02 , C07D401/02
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 取代的式(I)的苯炔基,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
-
公开(公告)号:US07414047B2
公开(公告)日:2008-08-19
申请号:US10690115
申请日:2003-10-21
申请人: Richard L. Apodaca , Jill A. Jablonowski , Kiev S. Ly , Chandravadan R. Shah , Devin M. Swanson , Wei Xiao
发明人: Richard L. Apodaca , Jill A. Jablonowski , Kiev S. Ly , Chandravadan R. Shah , Devin M. Swanson , Wei Xiao
IPC分类号: A61K31/55 , A61K31/54 , A61K31/535 , A61K31/497 , A61K31/4965 , A61P25/00 , C07D401/00 , C07D417/00 , C07D413/00 , C07D241/02 , C07D403/00
CPC分类号: C07D295/192 , A61K49/0004 , A61K51/0459 , A61K51/0463 , A61K51/0465 , A61K51/0468 , A61K51/047
摘要: Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 式(I)的取代的哌嗪基和二氮杂环庚烷基苯甲酰胺和苯并硫代酰胺,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
-
公开(公告)号:US06803362B2
公开(公告)日:2004-10-12
申请号:US10094357
申请日:2002-03-08
申请人: Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer D. Kreisberg , Annette K. Kwok , Timothy W. Lovenberg , Kiev S. Ly , Barbara Pio , Chandravadan R. Shah , Siguan Sun , Robin L. Thurmond , Jianmei Wei , Wei Xiao
发明人: Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer D. Kreisberg , Annette K. Kwok , Timothy W. Lovenberg , Kiev S. Ly , Barbara Pio , Chandravadan R. Shah , Siguan Sun , Robin L. Thurmond , Jianmei Wei , Wei Xiao
IPC分类号: A61K3133
CPC分类号: C07D401/12 , A61K31/496 , C07D209/42
摘要: Heterocyclic compounds and methods of making them and using them.
摘要翻译: 杂环化合物及其制备方法和使用方法。
-
公开(公告)号:US08575364B2
公开(公告)日:2013-11-05
申请号:US13126213
申请日:2009-10-29
IPC分类号: C07D205/04 , A61K31/397
CPC分类号: C07D211/46 , A61K31/397 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/12 , C07D211/48
摘要: Certain biphenyl compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译: 某些联苯化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
-
公开(公告)号:US07504426B2
公开(公告)日:2009-03-17
申请号:US10655381
申请日:2003-09-04
申请人: Nicholas I. Carruthers , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Kiev S. Ly , Barbara A. Pio , Chandravadan R. Shah , Jennifer D. Venable
发明人: Nicholas I. Carruthers , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Kiev S. Ly , Barbara A. Pio , Chandravadan R. Shah , Jennifer D. Venable
IPC分类号: C07D235/00 , A01N43/05 , A61K31/415
CPC分类号: C07D235/24 , C07D263/58 , C07D277/68 , C07D403/06 , C07D451/04 , C07D471/04
摘要: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
摘要翻译: 公开了某些噻吩并吡喃基和呋喃并吡咯基化合物可用于治疗或预防由组胺H 4受体介导的病症和病症,包括过敏性鼻炎。
-
公开(公告)号:US20080132540A1
公开(公告)日:2008-06-05
申请号:US11942387
申请日:2007-11-19
申请人: Nicholas I. Carruthers , Wenying Chai , Scott L. Dax , Jill A. Jablonowski , Xiaobing Li , Timothy W. Lovenberg , William V. Murray , Dale A. Rudolph , Mark Seierstad , Mark A. Youngman
发明人: Nicholas I. Carruthers , Wenying Chai , Scott L. Dax , Jill A. Jablonowski , Xiaobing Li , Timothy W. Lovenberg , William V. Murray , Dale A. Rudolph , Mark Seierstad , Mark A. Youngman
IPC分类号: A61K31/4545 , A61K31/404 , A61P25/24 , A61P3/04 , A61P25/00 , A61K31/454
CPC分类号: C07D401/12 , C07D401/14 , C07D409/14
摘要: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译: 本发明提供了用于治疗或预防:抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子治疗反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能,特别是由垂体和下丘脑腺体控制的内分泌功能,因此可用于治疗或预防排卵和不育症。
-
公开(公告)号:US07265135B2
公开(公告)日:2007-09-04
申请号:US10757625
申请日:2004-01-14
申请人: Michael Bogenstaetter , Nicholas I. Carruthers , Jill A. Jablonowski , Timothy W. Lovenberg , Kiev S. Ly
发明人: Michael Bogenstaetter , Nicholas I. Carruthers , Jill A. Jablonowski , Timothy W. Lovenberg , Kiev S. Ly
IPC分类号: C07D401/12 , C07D401/14 , C07D233/84 , A61K31/4178 , A61P25/08
CPC分类号: C07D401/12 , C07D233/70 , C07D233/84 , C07D403/12
摘要: The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compounds and methods of using them in the treatment of neurological disorders and other disorders and conditions mediated by the histamine H3 receptor.
摘要翻译: 本发明涉及式(I)的新型2-氧基,2-氨基和2-硫代咪唑化合物:其中所有变量如本文所定义,含有该化合物的药物组合物及其用于治疗神经障碍的方法 和由组胺H 3 N受体介导的其它病症和病症。
-
-
-
-
-
-
-
-
-