-
公开(公告)号:US06884803B2
公开(公告)日:2005-04-26
申请号:US10307870
申请日:2002-12-02
申请人: Richard Apodaca , Wei Xiao , Jill A. Jablonowski
发明人: Richard Apodaca , Wei Xiao , Jill A. Jablonowski
IPC分类号: C07D295/12 , A61K31/444 , A61K31/4453 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/08 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/28 , A61P27/14 , A61P27/16 , A61P37/08 , A61P43/00 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/66 , C07D213/38 , C07D215/06 , C07D215/12 , C07D239/42 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10 , C07D491/113 , C07D403/06 , A61K31/495 , A61P25/24 , C07D295/04
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/38 , C07D215/06 , C07D273/00 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10
摘要: Disclosed are substituted phenylalkynes of formula (I), wherein R1, R2, R3, R4, R5 and n are as defined, compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 公开了式(I)的取代的苯基炔,其中R 1,R 2,R 3,R 4, R 5和n如上所定义,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
-
公开(公告)号:US07446104B2
公开(公告)日:2008-11-04
申请号:US11874327
申请日:2007-10-18
申请人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
IPC分类号: C07D295/04 , A61K31/54
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 取代的式(I)的苯炔基,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
-
公开(公告)号:US07288540B2
公开(公告)日:2007-10-30
申请号:US11490394
申请日:2006-07-20
申请人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
IPC分类号: C07D413/06 , A61K31/5377
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I) compositions containing them and their methods of use to treat histamine related disorders are described, wherein R1, R2, R3, R4, R5 and n are as defined.
摘要翻译: 描述了含有它们的式(I)的组合物的取代苯炔基及其用于治疗组胺相关病症的方法,其中R 1,R 2,R 3, R 4,R 4,R 5和n如上所定义。
-
公开(公告)号:US07482364B2
公开(公告)日:2009-01-27
申请号:US11874321
申请日:2007-10-18
申请人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
IPC分类号: A61K31/54 , A61K31/445 , C07D239/02 , C07D401/02
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 取代的式(I)的苯炔基,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
-
5.Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase 有权
标题翻译: 哌嗪基和哌啶基脲作为脂肪酸酰胺水解酶的调节剂公开(公告)号:US07598249B2
公开(公告)日:2009-10-06
申请号:US11321710
申请日:2005-12-29
IPC分类号: A61K31/497 , A61K31/445 , A01N43/40 , C07D241/04 , C07D211/00 , C07D295/00
CPC分类号: C07D295/195 , C07D207/335 , C07D209/08 , C07D209/14 , C07D209/82 , C07D211/16 , C07D213/38 , C07D213/56 , C07D213/61 , C07D213/75 , C07D215/12 , C07D215/18 , C07D239/42 , C07D241/42 , C07D295/20 , C07D295/215 , C07D307/79 , C07D307/81 , C07D317/46 , C07D317/58 , C07D319/16 , C07D319/18 , C07D333/58 , C07D333/60 , C07D401/12 , C07D405/12 , C07D417/12
摘要: Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).
摘要翻译: 某些哌嗪基和哌啶基脲化合物可用作FAAH抑制剂。 此类化合物可用于治疗由脂肪酰胺水解酶(FAAH)活性介导的疾病状态,病症和病症的药物组合物和方法。 因此,可以施用化合物以治疗例如焦虑,疼痛,炎症,睡眠障碍,进食障碍或运动障碍(例如多发性硬化症)。
-
公开(公告)号:US07429586B2
公开(公告)日:2008-09-30
申请号:US11453422
申请日:2006-06-15
申请人: Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
发明人: Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
IPC分类号: A61K31/435 , C07D217/00
CPC分类号: C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 式(I)的取代的芳氧基烷基胺,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
-
公开(公告)号:US20070072837A1
公开(公告)日:2007-03-29
申请号:US11556941
申请日:2006-11-06
申请人: Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
IPC分类号: A61K31/54 , A61K31/5375 , A61K31/513 , A61K31/496 , A61K31/495 , A61K31/396 , A61K31/444 , A61K31/4545
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 取代的式(I)的苯炔基,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
-
公开(公告)号:US20100292266A1
公开(公告)日:2010-11-18
申请号:US12227756
申请日:2007-05-25
IPC分类号: A61K31/454 , C07D413/06 , C07D413/14 , C07D471/04 , A61K31/4545 , C07D491/056 , A61K31/4709 , A61P29/00 , A61P25/00 , A61P35/00 , A61P1/08 , A61P1/04
CPC分类号: C07D413/06 , C07D413/14 , C07D471/04 , C07D491/04
摘要: Certain oxazolyl piperidine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).
摘要翻译: 描述了某些恶唑基哌啶化合物,其可用作FAAH抑制剂。 此类化合物可用于治疗由脂肪酰胺水解酶(FAAH)活性介导的疾病状态,病症和病症的药物组合物和方法。 因此,可以施用化合物以治疗例如焦虑,疼痛,炎症,睡眠障碍,进食障碍或运动障碍(例如多发性硬化症)。
-
公开(公告)号:US20080056991A1
公开(公告)日:2008-03-06
申请号:US11928006
申请日:2007-10-30
申请人: Richard Apodaca , Jill Jablonowski , Kiew Ly , Chandravadan Shah , Devin Swanson , Wei Xiao
发明人: Richard Apodaca , Jill Jablonowski , Kiew Ly , Chandravadan Shah , Devin Swanson , Wei Xiao
IPC分类号: C07D295/10 , A61K31/495 , A61K31/496 , A61K31/5355 , C07D401/10 , C07D413/10 , C07D417/10 , C07D403/10 , A61K31/55 , A61K51/04 , A61P37/08
CPC分类号: C07D295/192 , A61K49/0004 , A61K51/0459 , A61K51/0463 , A61K51/0465 , A61K51/0468 , A61K51/047
摘要: Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 式(I)的取代的哌嗪基和二氮杂环庚烷基苯甲酰胺和苯并硫代酰胺,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
-
10.PIPERAZINYL AND PIPERIDINYL UREAS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE 有权
标题翻译: 作为脂肪酸酰胺水解酶的调节剂的哌嗪和哌啶酸公开(公告)号:US20100004261A1
公开(公告)日:2010-01-07
申请号:US12557650
申请日:2009-09-11
IPC分类号: A61K31/496 , C07D401/12 , C07D401/14 , C07D417/14 , A61P25/00 , A61P25/22 , A61P29/00 , A61P3/00 , A61P25/28 , A61P25/08 , A61P1/00 , A61P27/02 , A61P25/16 , A61P27/06 , A61P31/18 , A61P31/00 , A61P19/02 , A61P9/00 , A61P9/12 , A61P35/00 , A61P11/00 , A61P15/00 , A61P15/04 , A61P17/04
CPC分类号: C07D295/195 , C07D207/335 , C07D209/08 , C07D209/14 , C07D209/82 , C07D211/16 , C07D213/38 , C07D213/56 , C07D213/61 , C07D213/75 , C07D215/12 , C07D215/18 , C07D239/42 , C07D241/42 , C07D295/20 , C07D295/215 , C07D307/79 , C07D307/81 , C07D317/46 , C07D317/58 , C07D319/16 , C07D319/18 , C07D333/58 , C07D333/60 , C07D401/12 , C07D405/12 , C07D417/12
摘要: Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).
摘要翻译: 某些哌嗪基和哌啶基脲化合物可用作FAAH抑制剂。 此类化合物可用于治疗由脂肪酰胺水解酶(FAAH)活性介导的疾病状态,病症和病症的药物组合物和方法。 因此,可以施用化合物以治疗例如焦虑,疼痛,炎症,睡眠障碍,进食障碍或运动障碍(例如多发性硬化症)。
-
-
-
-
-
-
-
-
-