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公开(公告)号:US20050096364A1
公开(公告)日:2005-05-05
申请号:US10637099
申请日:2003-08-08
申请人: Jeffrey Romine , Scott Martin , Lawrence Snyder , Michael Serrano-Wu , Milind Deshpande , Darren Whitehouse , Julie Lemm , Donald O'Boyle , Min Gao , Richard Colonno
发明人: Jeffrey Romine , Scott Martin , Lawrence Snyder , Michael Serrano-Wu , Milind Deshpande , Darren Whitehouse , Julie Lemm , Donald O'Boyle , Min Gao , Richard Colonno
IPC分类号: A61K31/00 , A61K31/426 , A61K38/20 , A61K38/21 , A61K45/06 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , C07D277/38
CPC分类号: C07D417/04 , A61K31/00 , A61K31/426 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , A61K45/06 , C07D277/42 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , A61K2300/00
摘要: Compounds having the structure of formula I are described wherein R, R′, R1, R2, and R3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular the function of the HCV NS5A protein.
摘要翻译: 描述了具有式I结构的化合物,其中R 1,R 2,R 1,R 2和R 3均如 规范。 该化合物可以抑制丙型肝炎病毒(HCV)复制,特别是HCV NS5A蛋白的功能。
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公开(公告)号:US20050069522A1
公开(公告)日:2005-03-31
申请号:US10637156
申请日:2003-08-08
申请人: Richard Colonno , Julie Lemm , Donald O'Boyle , Min Gao , Jeffrey Romine , Scott Martin , Lawrence Snyder , Michael Serrano-Wu , Milind Deshpande , Darren Whitehouse
发明人: Richard Colonno , Julie Lemm , Donald O'Boyle , Min Gao , Jeffrey Romine , Scott Martin , Lawrence Snyder , Michael Serrano-Wu , Milind Deshpande , Darren Whitehouse
IPC分类号: A61K31/00 , A61K31/426 , A61K38/20 , A61K38/21 , A61K45/06 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , A61K48/00
CPC分类号: C07D417/04 , A61K31/00 , A61K31/426 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , A61K45/06 , C07D277/42 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , A61K2300/00
摘要: Disclosed are combination pharmaceutical agents for the treatment of an HCV infection comprising a compound effective to inhibit the function of the HCV NS5A protein and another compound having anti-HCV activity. Compounds which can inhibit the function of the NS5A protein having the structure of formula I are described wherein R, R′, R1, R2, and R3 are as defined in the specification. The other compounds having anti-HCV activity are effective to inhibit the function of a target selected from the group consisting of HCV metalloprotease, HCV serine protease, HCV polymerase, HCV helicase, HCV NS4B protein, HCV entry, HCV assembly, HCV egress, HCV NS5A protein, IMPDH and a nucleoside analog for the treatment of an HCV infection.
摘要翻译: 公开了用于治疗HCV感染的组合药剂,其包含有效抑制HCV NS5A蛋白的功能的化合物和另一种具有抗HCV活性的化合物。 描述了可以抑制具有式I结构的NS5A蛋白的功能的化合物,其中R,R',R 1,R 2和R 3如说明书中所定义。 具有抗HCV活性的其它化合物可有效抑制选自HCV金属蛋白酶,HCV丝氨酸蛋白酶,HCV聚合酶,HCV解旋酶,HCV NS4B蛋白,HCV进入,HCV组装,HCV出血,HCV NS5A蛋白,IMPDH和用于治疗HCV感染的核苷类似物。
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公开(公告)号:US20050075376A1
公开(公告)日:2005-04-07
申请号:US10922096
申请日:2004-08-19
申请人: Peter Glunz , Brent Douty , Scott Martin , Jeffrey Romine
发明人: Peter Glunz , Brent Douty , Scott Martin , Jeffrey Romine
IPC分类号: C07D231/12 , C07D231/14 , C07D233/54 , A61K31/427 , A61K31/41 , A61K31/416 , A61K31/4178 , A61K31/421 , A61K31/4245 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号: C07D231/12 , C07D231/14
摘要: Compounds of Formula I are disclosed which inhibit hepatitis C NS5B RNA-dependent RNA polymerase and are useful for treating hepatitis C. Compositions and methods of using these compounds are also disclosed.
摘要翻译: 公开了抑制丙型肝炎NS5B RNA依赖性RNA聚合酶并可用于治疗丙型肝炎的式I化合物。还公开了使用这些化合物的组合物和方法。
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公开(公告)号:US07112601B2
公开(公告)日:2006-09-26
申请号:US10922096
申请日:2004-08-19
IPC分类号: A61K31/415 , C07D231/12 , C07D231/14 , C07D231/16
CPC分类号: C07D231/12 , C07D231/14
摘要: Compounds of Formula I are disclosed which inhibit hepatitis C NS5B RNA-dependent RNA polymerase and are useful for treating hepatitis C. Compositions and methods of using these compounds are also disclosed
摘要翻译: 公开了抑制丙型肝炎NS5B RNA依赖性RNA聚合酶并可用于治疗丙型肝炎的式I化合物。也公开了使用这些化合物的组合物和方法
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公开(公告)号:US20050119318A1
公开(公告)日:2005-06-02
申请号:US10974588
申请日:2004-10-27
申请人: Thomas Hudyma , Xiaofan Zheng , Jeffrey Romine
发明人: Thomas Hudyma , Xiaofan Zheng , Jeffrey Romine
IPC分类号: C07D405/04 , C07D405/14 , C07D417/02 , A61K31/405 , A61K31/422 , A61K31/427 , C07D413/02 , C07D43/02
CPC分类号: C07D405/04 , C07D405/14
摘要: Compounds having the structure of formula (I) are disclosed. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular the function of the HCV NS5B protein.
摘要翻译: 公开了具有式(I)结构的化合物。 该化合物可以抑制丙型肝炎病毒(HCV)复制,特别是HCV NS5B蛋白的功能。
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