公开(公告)号：US06465482B2

公开(公告)日：2002-10-15

申请号：US09969910

申请日：2001-10-03

申请人： Richard E. Mewshaw ,  Ping Zhou ,  Dahui Zhou ,  Kristin L. Meagher ,  Magda Asselin ,  Deborah A. Evrard ,  Adam M. Gilbert

发明人： Richard E. Mewshaw ,  Ping Zhou ,  Dahui Zhou ,  Kristin L. Meagher ,  Magda Asselin ,  Deborah A. Evrard ,  Adam M. Gilbert

IPC分类号： A61K31454

CPC分类号： C07D401/08 ,  C07D209/14 ,  C07D209/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

摘要： Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R1, R2 and R3 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, alkylaryl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.

摘要翻译： 提供了可用于治疗受5-羟色胺影响的神经系统疾病的化合物，其包括：R 1，R 2和R 3各自独立地为氢，卤素，CF 3，烷基，烷氧基，MeSO 2或一起可以形成5-7元碳环 或杂环; R 4为氢，卤素或烷基; R 5为氢，烷基，烷基芳基或芳基; R 6为氢，卤素，CF 3，CN，脲或烷氧基; X 1，X 2和X 3为碳或 X1，X2或X3可以是氮; Y是碳或氮; Z为碳或氮; 其药学上可接受的盐。

公开(公告)号：US06489342B2

公开(公告)日：2002-12-03

申请号：US10002340

申请日：2001-11-15

申请人： Richard E. Mewshaw ,  Dahui Zhou ,  Ping Zhou

发明人： Richard E. Mewshaw ,  Dahui Zhou ,  Ping Zhou

IPC分类号： A61K31454

CPC分类号： C07D401/14

摘要： This invention provides aryloxy indole derivatives which are useful for the treatment of diseases affected by disorders of the serotonin-affected neurological systems, such as depression and anxiety, the compounds having the formula: wherein R1 is H or alkyl; R2, R3, and R4 are H, alkyl, or halogen; X is H, halogen, CN, or C1-C6 alkoxy; Z is (CH2)n or carbonyl; n is 1 or 2; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供了芳氧基吲哚衍生物，其可用于治疗受血清素受影响的神经系统疾病如抑郁和焦虑影响的疾病，具有下式的化合物：其中R1是H或烷基; R2，R3和R4是H，烷基或卤素; X是H，卤素，CN或C 1 -C 6烷氧基; Z是（CH 2）n或羰基; n为1或2; 虚线表示可选的双键; 或其药学上可接受的盐。

公开(公告)号：US06313126B1

公开(公告)日：2001-11-06

申请号：US09476254

申请日：1999-12-30

申请人： Richard E. Mewshaw ,  Ping Zhou ,  Dahui Zhou ,  Kristin L. Meagher ,  Magda Asselin ,  Deborah A. Evrard ,  Adam M. Gilbert

发明人： Richard E. Mewshaw ,  Ping Zhou ,  Dahui Zhou ,  Kristin L. Meagher ,  Magda Asselin ,  Deborah A. Evrard ,  Adam M. Gilbert

IPC分类号： A61K31496

CPC分类号： C07D401/08 ,  C07D209/14 ,  C07D209/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

摘要： Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R1, R2 and R3 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, alkylaryl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.

摘要翻译： 提供了可用于治疗受5-羟色胺影响的神经系统疾病的化合物，其包括：R 1，R 2和R 3各自独立地为氢，卤素，CF 3，烷基，烷氧基，MeSO 2或一起可以形成5-7元碳环 或杂环; R 4为氢，卤素或烷基; R 5为氢，烷基，烷基芳基或芳基; R 6为氢，卤素，CF 3，CN，脲或烷氧基; X 1，X 2和X 3为碳或 X1，X2或X3可以是氮; Y是碳或氮; Z为碳或氮; 其药学上可接受的盐。

公开(公告)号：US6110956A

公开(公告)日：2000-08-29

申请号：US287416

申请日：1999-04-07

申请人： Richard E. Mewshaw ,  Dahui Zhou ,  Ping Zhou

发明人： Richard E. Mewshaw ,  Dahui Zhou ,  Ping Zhou

IPC分类号： A61P25/24 ,  C07D209/14 ,  C07D403/12 ,  C07D405/12 ,  A61K31/404 ,  A61K31/4045 ,  C07D209/04 ,  C07D403/08

CPC分类号： C07D403/12 ,  C07D209/14 ,  C07D405/12

摘要： Compounds effective in treating disorders of the serotonin-affected neurological systems are provided, such compounds having the following formula: ##STR1## wherein: R.sub.1 and R.sub.2 are each, independently, hydrogen, halogen, CF.sub.3, lower alkyl, lower alkoxy, MeSO.sub.2, or together can form a 5-7 membered carbocyclic or heterocyclic ring;R.sub.3 is alkoxy, halogen, hydrogen or carbamoyl;R.sub.4 is hydrogen, hydroxy, lower alkyl, or lower alkoxy;R.sub.5 is hydrogen, lower alkyl, or halogen;R.sub.6 is hydrogen, lower alkyl, or phenyl;R.sub.7 is hydrogen, lower alkyl, lower alkoxy, halogen, CN, CF.sub.3, or hydroxy; andX is (CH.sub.2).sub.n,wherein n is 0 to 3; or pharmaceutically acceptable salts thereof.

摘要翻译： 提供了有效治疗受5-羟色胺影响的神经系统疾病的化合物，具有下式的化合物：其中：R 1和R 2各自独立地为氢，卤素，CF 3，低级烷基，低级烷氧基，MeSO 2或一起可形成 5-7元碳环或杂环; R3是烷氧基，卤素，氢或氨基甲酰基; R4是氢，羟基，低级烷基或低级烷氧基; R5是氢，低级烷基或卤素; R6是氢，低级烷基或苯基; R7是氢，低级烷基，低级烷氧基，卤素，CN，CF3或羟基; X为（CH 2）n，n为0〜3; 或其药学上可接受的盐。

公开(公告)号：US06610712B2

公开(公告)日：2003-08-26

申请号：US10000642

申请日：2001-11-15

申请人： Richard E. Mewshaw ,  Dahui Zhou ,  Ping Zhou

发明人： Richard E. Mewshaw ,  Dahui Zhou ,  Ping Zhou

IPC分类号： C07D40104

CPC分类号： C07D401/06 ,  C07D405/14

摘要： This invention provides compounds useful in treating serotonin-related central nervous system disorders, including anxiety, generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, sleep disorders, sexual dysfunction, alcohol and drug addiction, Alzheimer's disease, Parkinson's disease, obesity and migraine, the compounds having the general formula: wherein: R1 and R2 may each be H or an alkyl or alkoxy group; or R1 and R2 may be concatenated to form a bicyclic ring system with the phenyl ring to which they are bound; X is selected from hydrogen, halogen, cyano, C1-C6 alkoxy; Z is (CH2)n or carbonyl; n is 0, 1 or 2; the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供了可用于治疗血清素相关的中枢神经系统疾病的化合物，包括焦虑，广泛性焦虑症，恐慌症，强迫症，睡眠障碍，性功能障碍，酒精和药物成瘾，阿尔茨海默病，帕金森病，肥胖症和偏头痛 具有以下通式的化合物：其中：R 1和R 2可以各自为H或烷基或烷氧基; 或者R 1和R 2可以连接形成与它们所结合的苯环的双环系统; X选自氢，卤素，氰基，C 1 -C 6烷氧基; Z是（CH 2）n或羰基; n为0,1或2; 虚线表示可选的双键; 或其药学上可接受的盐。

公开(公告)号：US06313114B1

公开(公告)日：2001-11-06

申请号：US09475940

申请日：1999-12-30

申请人： Richard E. Mewshaw ,  Dahui Zhou ,  Ping Zhou

发明人： Richard E. Mewshaw ,  Dahui Zhou ,  Ping Zhou

IPC分类号： C07D41312

CPC分类号： C07D413/12

摘要： Compounds are provided which have the following formula: wherein: R is hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, or substituted phenyl; X and Y are each, independently, hydrogen, halogen, cyano, or alkoxy of 1 to 6 carbon atoms; and m is 1 to 5; or a pharmaceutically acceptable salt thereof.

摘要翻译： 提供具有下式的化合物：其中：R是氢，1至6个碳原子的烷基，苯基或取代的苯基; X和Y各自独立地是氢，卤素，氰基或1-6个碳的烷氧基 原子 andm是1到5; 或其药学上可接受的盐。

公开(公告)号：US6162803A

公开(公告)日：2000-12-19

申请号：US287676

申请日：1999-04-07

申请人： Richard E. Mewshaw ,  Ping Zhou

发明人： Richard E. Mewshaw ,  Ping Zhou

IPC分类号： C07D413/12 ,  A61K31/536 ,  A61K31/4985 ,  C07D215/12 ,  C07D241/38 ,  C07D413/08

CPC分类号： C07D413/12

摘要： Compounds effective in treating disorders of the serotonin-affected neurological symptoms are provided, such compounds having the following formula: ##STR1## wherein: R.sub.1 and R.sub.5 are each, independently, hydrogen, halogen, lower alkoxy, lower alkyl, cyano, or trifluoromethyl;R.sub.2 and R.sub.4 are each, independently, hydrogen, lower alkyl, phenyl, or substituted phenyl;R.sub.3 is hydrogen or lower alkyl; andX and Y are each, independently, O, NR.sub.6, or CH.sub.2, whereinR.sub.6 is hydrogen, lower alkyl, phenyl, or substituted phenyl; or pharmaceutically acceptable salts thereof.

摘要翻译： 提供了有效治疗血清素受影响的神经症状的疾病的化合物，具有下式的化合物：其中：R 1和R 5各自独立地为氢，卤素，低级烷氧基，低级烷基，氰基或三氟甲基; R2和R4各自独立地为氢，低级烷基，苯基或取代的苯基; R3是氢或低级烷基; 并且X和Y各自独立地是O，NR 6或CH 2，其中R 6是氢，低级烷基，苯基或取代的苯基; 或其药学上可接受的盐。

公开(公告)号：US20130055206A1

公开(公告)日：2013-02-28

申请号：US13217826

申请日：2011-08-25

申请人： Clark A. Dudek ,  Kobina K. Inkumsah ,  David B. Roberts ,  Adrian X. Rodriguez ,  Ping Zhou

发明人： Clark A. Dudek ,  Kobina K. Inkumsah ,  David B. Roberts ,  Adrian X. Rodriguez ,  Ping Zhou

IPC分类号： G06F9/44 ,  G06F9/455

CPC分类号： G06F9/45558 ,  G06F11/3644 ,  G06F11/366 ,  G06F2009/45591

摘要： Methods, apparatuses, and computer program products for synchronously debugging a software program using a plurality of virtual machines are provided. Embodiments include controlling, by a master debugging module operating on a first virtual machine, execution of the software program within the first virtual machine; controlling, by a slave debugging module operating on a second virtual machine, execution of the software program within the second virtual machine including delaying execution of the software program within the second virtual machine relative to the execution of the software program within the first virtual machine; detecting, by the master debugging module, an error in the execution of the software program within the first virtual machine; and in response to the detection of the error, capturing, by a hypervisor, a snapshot of the second virtual machine.

摘要翻译： 提供了用于使用多个虚拟机同步调试软件程序的方法，装置和计算机程序产品。 实施例包括通过在第一虚拟机上操作的主调试模块来控制第一虚拟机内的软件程序的执行; 通过在第二虚拟机上操作的从属调试模块来控制第二虚拟机内的软件程序的执行，包括相对于第一虚拟机内的软件程序的执行延迟第二虚拟机内的软件程序的执行; 由所述主调试模块检测所述第一虚拟机内的所述软件程序的执行中的错误; 并且响应于错误的检测，由管理程序捕获第二虚拟机的快照。

公开(公告)号：US20120317073A1

公开(公告)日：2012-12-13

申请号：US13300003

申请日：2011-11-18

申请人： Ping Zhou ,  Stephen Shepherd

发明人： Ping Zhou ,  Stephen Shepherd

IPC分类号： G06F7/00

CPC分类号： G06F16/27

摘要： A method, system and computer readable storage medium for replicating procedures with unsupported table data type arguments such as Boolean arguments. The method includes identifying the argument of an unsupported table data type in a procedure to be replicated, mapping the argument to an equivalent supported value, and creating a table containing a column representing the argument as the supported table data type and sending data corresponding to the unsupported table data type argument to a replication server.

摘要翻译： 用于使用不支持的表数据类型参数（如布尔参数）复制过程的方法，系统和计算机可读存储介质。 该方法包括在要复制的过程中识别不支持的表数据类型的参数，将参数映射到等效的支持值，以及创建包含表示参数的列作为支持的表数据类型的表，并发送对应于 不支持的表数据类型参数到复制服务器。

公开(公告)号：US08320259B2

公开(公告)日：2012-11-27

申请号：US12527808

申请日：2008-01-18

申请人： Ping Zhou ,  Andrew D Chattell ,  Mark Hockly

发明人： Ping Zhou ,  Andrew D Chattell ,  Mark Hockly

IPC分类号： H04J3/14

CPC分类号： H04M3/30 ,  H04M3/007 ,  H04M3/2209 ,  H04M2201/18

摘要： A test system for testing a pair of telecommunications access networks, e.g. as part of transfer engineering. The system comprises a test head for connection, via an access arrangement, to first and second access networks. In a first phase, the access arrangement is arranged to connect the test head to the first access network for sending a first request from the tester to, for example, a CLI server via the first access network. The first request comprises a parameter associated with a user line. The tester is arranged to receive in response to the first request a first identifier from the server. In a second phase, the access arrangement is arranged to connect the test head to the second access network for sending a second request from the test head through the second access network to, for example, a CLI server. The second request also comprises the parameter. The tester is arranged to receive, in response to the second request, a second identifier from the target server and is arranged to carry out a comparison operation involving the first and second identifiers received in response to the two requests. A mismatch can indicate a fault or misconnection in either access network or a problem with network configuration data.

摘要翻译： 用于测试一对电信接入网络的测试系统，例如， 作为转移工程的一部分。 该系统包括用于经由接入装置连接到第一和第二接入网络的测试头。 在第一阶段中，访问装置被布置成将测试头连接到第一接入网络，用于经由第一接入网络将来自测试者的第一请求发送到例如CLI服务器。 第一请求包括与用户线相关联的参数。 测试器被安排为响应于第一请求接收来自服务器的第一标识符。 在第二阶段中，访问装置被布置成将测试头连接到第二接入网络，用于通过第二接入网络将测试头的第二请求发送到例如CLI服务器。 第二个请求也包括参数。 所述测试器被安排为响应于所述第二请求从所述目标服务器接收第二标识符，并且被布置为执行涉及响应于所述两个请求而接收到的所述第一和第二标识符的比较操作。 不匹配可以指示任一接入网络中的故障或连接错误或网络配置数据的问题。