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公开(公告)号:US07998993B2
公开(公告)日:2011-08-16
申请号:US12256931
申请日:2008-10-23
申请人: Richard J. Perner , John R. Koenig , Stanley DiDomenico, Jr. , Erol K. Bayburt , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Anil Vasudevan , Eric Voight
发明人: Richard J. Perner , John R. Koenig , Stanley DiDomenico, Jr. , Erol K. Bayburt , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Anil Vasudevan , Eric Voight
IPC分类号: A61K31/421 , C07D263/48
CPC分类号: C07D413/12 , C07D263/48 , C07D413/04
摘要: Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV 1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 在描述中定义R1,R2,R4和W的式(I)化合物是具有CNS穿透的TRPV 1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US20090124666A1
公开(公告)日:2009-05-14
申请号:US12256931
申请日:2008-10-23
申请人: Richard J. Perner , John R. Koenig , Stanley Didomenico, JR. , Erol K. Bayburt , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Anil Vasudevan , Eric Voight
发明人: Richard J. Perner , John R. Koenig , Stanley Didomenico, JR. , Erol K. Bayburt , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Anil Vasudevan , Eric Voight
IPC分类号: A61K31/4439 , C07D263/48 , C07D413/10 , A61P25/00 , A61K31/421
CPC分类号: C07D413/12 , C07D263/48 , C07D413/04
摘要: Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV 1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 在描述中定义R1,R2,R4和W的式(I)化合物是具有CNS穿透的TRPV 1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US20060211739A1
公开(公告)日:2006-09-21
申请号:US11344920
申请日:2006-02-01
申请人: Arturo Perez-Medrano , Derek Nelson , William Carroll , Michael Kort , Robert Gregg , Eric Voight , Michael Jarvis , Elizabeth Kowaluk
发明人: Arturo Perez-Medrano , Derek Nelson , William Carroll , Michael Kort , Robert Gregg , Eric Voight , Michael Jarvis , Elizabeth Kowaluk
IPC分类号: A61K31/4439 , A61K31/41
CPC分类号: A61K31/381 , A61K31/41 , A61K31/4439
摘要: The present invention relates to the use of selective P2X7 receptor antagonists of formula I, or a pharmaceutically acceptable salt or prodrug thereof wherein D, R1 and R2 are as defined in claim 1, for the treatment of neuropathic pain, chronic inflammatory pain, inflammation, neurodegeneration and for promoting neuroregeneration,
摘要翻译: 本发明涉及式I的选择性P2X 7受体拮抗剂或其药学上可接受的盐或前药,其中D,R 1和R 2 用于治疗神经性疼痛,慢性炎性疼痛,炎症,神经变性和促进神经再生的权利要求1中所定义,
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