公开(公告)号：US06927382B2

公开(公告)日：2005-08-09

申请号：US10153243

申请日：2002-05-22

申请人： David Andrew King ,  Richard J. Pittaro ,  Shahida Rana ,  Edward Verdonk ,  Frederick A. Stawitcke ,  Richard D. Pering

发明人： David Andrew King ,  Richard J. Pittaro ,  Shahida Rana ,  Edward Verdonk ,  Frederick A. Stawitcke ,  Richard D. Pering

IPC分类号： H01L21/98 ,  H01L25/16 ,  H01L27/146 ,  H01L31/00 ,  H01L31/12

CPC分类号： H01L24/95 ,  H01L25/167 ,  H01L25/50 ,  H01L27/14683 ,  H01L31/125 ,  H01L2224/95085 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01027 ,  H01L2924/01033 ,  H01L2924/01049 ,  H01L2924/10158 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/12043 ,  H01L2924/00

摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and separately formed photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array including a plurality of individual photoreceptors is selectively etched back between photoreceptor locations to reveal a plurality of recessed regions having a certain geographic profile. A plurality of semiconductor blocks, each having light emitting capability and each having a certain geometric profile that is complementary in size and shape to the certain geometric profile of the recessed regions, are separately fabricated. These blocks are included within a fluid to form a slurry. The slurry is then flowed over the CMOS fabricated photodetector array in accordance with a fluidic self-assembly technique, and the included semiconductor blocks are individually deposited within each of the plurality of recessed regions in the CMOS fabricated photodetector array. The deposited blocks are then attached within the recessed regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and separately formed photoemitters.

摘要翻译： 本公开涉及一种光激励/检测装置，其包括阵列的多个光电检测器和单独形成的光电发生器，以及用于制造这种装置的方法。 包括多个单独光感受器的CMOS制造的光检测器阵列被选择性地在感光体位置之间回蚀刻以露出具有一定地理轮廓的多个凹陷区域。 分别制造多个半导体块，每个半导体块具有发光能力，并且各自具有与凹陷区域的某些几何轮廓尺寸和形状互补的一定几何轮廓。 这些块被包含在流体中以形成浆料。 然后根据流体自组装技术将浆料流过CMOS制造的光电检测器阵列，并且将所包含的半导体块分别沉积在CMOS制造的光电检测器阵列中的多个凹陷区域的每一个内。 然后将沉积的块附接在凹陷区域内，以从阵列的多个光电检测器和单独形成的光电发生器形成光学激发/检测装置。

公开(公告)号：US06657235B1

公开(公告)日：2003-12-02

申请号：US10153760

申请日：2002-05-22

申请人： Edward Verdonk ,  Richard J. Pittaro ,  Shahida Rana ,  David Andrew King ,  Frederick A. Stawitcke ,  Richard D. Pering

发明人： Edward Verdonk ,  Richard J. Pittaro ,  Shahida Rana ,  David Andrew King ,  Frederick A. Stawitcke ,  Richard D. Pering

IPC分类号： H01L2926

CPC分类号： H01L27/14643 ,  H01L25/0753 ,  H01L25/167 ,  H01L2924/0002 ,  H01L2924/00

摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and discrete photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array includes an arrayed plurality of photoreceptor areas and photoemitter areas, wherein each photoreceptor area includes a CMOS integrated photoreceptor and each photoemitter area includes at least two buried electric contact pads. The CMOS array is selectively etched back at the locations of the photoemitter areas for regions to reveal the buried contact pads. A plurality of discrete semiconductor photoemitter devices (such as, for example, light emitting diodes) are inserted into, and mechanically retained within, the regions of the CMOS fabricated photodetector array. The inserted discrete semiconductor photoemitter devices make electrical contact with the buried electric contact pads that are revealed within each of the regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and discrete semiconductor photoemitters.

摘要翻译： 本公开涉及包括阵列的多个光电探测器和分立光电发生器的光学激发/检测装置，以及用于制造这种装置的方法。 CMOS制造的光电检测器阵列包括阵列的多个感光体区域和光电发射器区域，其中每个感光体区域包括CMOS集成感光体，并且每个光电发射器区域包括至少两个埋入的电接触焊盘。 CMOS阵列在光电探测器区域的位置处被选择性地回蚀，用于区域以露出埋入的接触焊盘。 多个分立的半导体光电探测器装置（例如，发光二极管）被插入并机械地保持在CMOS制造的光电检测器阵列的区域内。 插入的分立半导体光电发生器装置与在每个区域内露出的掩埋电接触焊盘电接触，以从阵列的多个光电探测器和分立的半导体光电发生器形成光激发/检测装置。

公开(公告)号：US06640197B2

公开(公告)日：2003-10-28

申请号：US10072240

申请日：2002-02-08

申请人： Richard J. Pittaro ,  David Andrew King ,  Richard D. Pering ,  Shahida Rana ,  Frederick A. Stawitcke ,  Edward Verdonk

发明人： Richard J. Pittaro ,  David Andrew King ,  Richard D. Pering ,  Shahida Rana ,  Frederick A. Stawitcke ,  Edward Verdonk

IPC分类号： G01C2500

CPC分类号： G01N21/253

摘要： A sensor array is bonded to or molded together with a micro-lens array to form a sensor cartridge. The micro-lenses of the micro-lens array are configured to focus light incident on the sensors, into the sensors. An alignment structure has a mating profile that receives and engages one or more micro-lenses from the micro-lens array to laterally align the cartridge to enable repeatable precise positioning of the cartridge.

摘要翻译： 传感器阵列与微透镜阵列结合或模制在一起以形成传感器盒。 微透镜阵列的微透镜被配置为将入射到传感器上的光聚焦到传感器中。 对准结构具有匹配轮廓，该配合轮廓接收并接合来自微透镜阵列的一个或多个微透镜以横向对准盒，以使得盒的可重复的精确定位。

公开(公告)号：US06821793B2

公开(公告)日：2004-11-23

申请号：US10668435

申请日：2003-09-22

申请人： Edward Verdonk ,  Richard J. Pittaro ,  Shahida Rana ,  David Andrew King ,  Frederick A. Stawitcke ,  Richard D. Pering

发明人： Edward Verdonk ,  Richard J. Pittaro ,  Shahida Rana ,  David Andrew King ,  Frederick A. Stawitcke ,  Richard D. Pering

IPC分类号： H01L2100

CPC分类号： H01L27/14643 ,  H01L25/0753 ,  H01L25/167 ,  H01L2924/0002 ,  H01L2924/00

摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and discrete photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array includes an arrayed plurality of photoreceptor areas and photoemitter areas, wherein each photoreceptor area includes a CMOS integrated photoreceptor and each photoemitter area includes at least two buried electric contact pads. The CMOS array is selectively etched back at the locations of the photoemitter areas for regions to reveal the buried contact pads. A plurality of discrete semiconductor photoemitter devices (such as, for example, light emitting diodes) are inserted into, and mechanically retained within, the regions of the CMOS fabricated photodetector array. The inserted discrete semiconductor photoemitter devices make electrical contact with the buried electric contact pads that are revealed within each of the regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and discrete semiconductor photoemitters.

摘要翻译： 本公开涉及包括阵列的多个光电探测器和分立光电发生器的光学激发/检测装置，以及用于制造这种装置的方法。 CMOS制造的光电检测器阵列包括阵列的多个感光体区域和光电发射器区域，其中每个感光体区域包括CMOS集成感光体，并且每个光电发射器区域包括至少两个埋入的电接触焊盘。 CMOS阵列在光电探测器区域的位置处被选择性地回蚀，用于区域以露出埋入的接触焊盘。 多个分立的半导体光电探测器装置（例如，发光二极管）被插入并机械地保持在CMOS制造的光电检测器阵列的区域内。 插入的分立半导体光电发生器装置与在每个区域内露出的掩埋电接触焊盘电接触，以从阵列的多个光电探测器和分立的半导体光电发生器形成光激发/检测装置。

公开(公告)号：US06642498B2

公开(公告)日：2003-11-04

申请号：US09990609

申请日：2001-11-21

申请人： Edward Verdonk ,  David A. King ,  Richard D. Pering ,  Richard J. Pittaro ,  Shahida Rana ,  Frederick A. Stawitcke

发明人： Edward Verdonk ,  David A. King ,  Richard D. Pering ,  Richard J. Pittaro ,  Shahida Rana ,  Frederick A. Stawitcke

IPC分类号： G01J142

CPC分类号： G01N21/6452 ,  G01N21/645 ,  G01N2021/6463 ,  G01N2021/6482

摘要： The present invention is directed to a micromirror optical multiplexer for directing light to an array of sensors. The micromirror optical multiplexer directs light from one or more sources onto multiple, coplanar sensors for the purpose of exciting fluorescence. The micromirror optical multiplexer includes at least one light source and a micromirror array having a top face and up to four side faces. Pivotable mirrors of the micromirror array are arranged in a multiple row, multiple column format on the top face. In addition, each of the side faces of the micromirror array has at least one row of pivotable mirrors. By pivoting one side face mirror and one top face mirror, a light source entering at one corner of the micromirror array can be directed to exit near normal incidence anywhere on the bottom of the device.

摘要翻译： 本发明涉及一种用于将光引导到传感器阵列的微镜光学多路复用器。 微镜光复用器将来自一个或多个源的光引导到多个共面传感器上，以激发荧光。 微镜光复用器包括至少一个光源和具有顶面和多达四个侧面的微镜阵列。 微镜阵列的透视镜在顶面以多列，多列格式排列。 此外，微镜阵列的每个侧面具有至少一排可枢转镜。 通过枢转一个侧面反射镜和一个顶面反射镜，进入微镜阵列的一个角落处的光源可被引导到设备底部的任何地方的正常入射附近。

公开(公告)号：US06707958B2

公开(公告)日：2004-03-16

申请号：US09988468

申请日：2001-11-20

申请人： Richard D. Pering ,  David A. King ,  Richard J. Pittaro ,  Shahida Rana ,  Frederick A. Stawitcke ,  Edward D. Verdonk

发明人： Richard D. Pering ,  David A. King ,  Richard J. Pittaro ,  Shahida Rana ,  Frederick A. Stawitcke ,  Edward D. Verdonk

IPC分类号： G02B600

CPC分类号： G01N21/552 ,  B01L3/5085 ,  G01N35/028

摘要： A biochemical assay device optically scans individual biological sample containing wells in an assay plate. The device includes an imaging system overlaying the assay plate wherein a scanning light propagates by total internal reflection within an optical waveguide. The waveguide includes a plurality of pixel locations, each aligned with a well in the assay plate, at which total internal reflection is selectively frustrated to output an incident beam of light. That light illuminates the well and causes generation of an emission beam of light that is detected by a photoreceptor. The device further includes a driver circuit that controls the selective frustration of total internal reflection at each pixel location in order to scan each well in the assay plate. A processor is also included in the device to process the detected emission beams of light generated by the scanned wells for purposes of assaying the biological sample contained in each scanned well.

摘要翻译： 生物化学测定装置在测定板中光学扫描含有孔的各种生物样品。 该装置包括覆盖测定板的成像系统，其中扫描光通过光波导内的全内反射传播。 波导包括多个像素位置，每个像素位置与测定板中的阱对准，在该位置处，全内反射被选择性地挫败以输出入射光束。 该光照射井，并产生由感光体检测到的发射光束。 该装置还包括驱动器电路，其控制每个像素位置处的全内反射的选择性挫败，以扫描测定板中的每个孔。 为了分析每个扫描井中包含的生物样品的目的，处理器还包括在该装置中以处理由扫描井产生的检测到的发射光束。

公开(公告)号：US07179654B2

公开(公告)日：2007-02-20

申请号：US10100346

申请日：2002-03-18

申请人： Edward Verdonk ,  David Andrew King ,  Richard J. Pittaro

发明人： Edward Verdonk ,  David Andrew King ,  Richard J. Pittaro

IPC分类号： G01N21/76 ,  B32B5/02 ,  B32B27/12 ,  B32B27/04

CPC分类号： G01N21/6454 ,  G01N21/6428 ,  Y10T436/10

摘要： A biochemical sensor apparatus having an optical radiation source, a sensor array, and a photodetector array is disclosed. Each sensor of the sensor array includes fluorophores for fluorescence (generating response radiation) when mixed with analytes of interest and exposed to stimulus radiation. An array of photodetectors, such as a CMOS imaging array is used to detect the response radiation. The detected response radiation is converted to digital values and the digital values used to analyze various properties of the analytes present in the sensors.

摘要翻译： 公开了一种具有光辐射源，传感器阵列和光电检测器阵列的生化传感器装置。 传感器阵列的每个传感器包括与感兴趣的分析物混合并暴露于刺激辐射时用于荧光的荧光团（产生响应辐射）。 使用诸如CMOS成像阵列的光电检测器阵列来检测响应辐射。 检测到的响应辐射被转换为数字值，数字值用于分析传感器中存在的分析物的各种性质。

公开(公告)号：US06298735B1

公开(公告)日：2001-10-09

申请号：US09298335

申请日：1999-04-23

申请人： J. Fleming Dias ,  Richard D. Pering ,  Henry E. Karrer ,  Richard J. Pittaro

发明人： J. Fleming Dias ,  Richard D. Pering ,  Henry E. Karrer ,  Richard J. Pittaro

IPC分类号： G01F166

CPC分类号： G01F1/667 ,  Y10T29/42 ,  Y10T29/49002 ,  Y10T29/49011

摘要： An accurate and reliable pneumotachometer with annular ring transducers for determining the velocity of a fluid flow is provided. A novel and accurate flow measurement system for measuring transit time of a fluid flow using chirp signals and a pneumotachometer with annular ring transducers is also disclosed.

公开(公告)号：US06658710B2

公开(公告)日：2003-12-09

申请号：US09888742

申请日：2001-06-25

申请人： J. Fleming Dias ,  Richard D. Pering ,  Henry E. Karrer ,  Richard J. Pittaro

发明人： J. Fleming Dias ,  Richard D. Pering ,  Henry E. Karrer ,  Richard J. Pittaro

IPC分类号： H04R1700

CPC分类号： G01F1/667 ,  Y10T29/42 ,  Y10T29/49002 ,  Y10T29/49011

摘要： A method is provided for fabricating an annular ring transducers for determining the velocity of a fluid flow. A novel and accurate flow measurement system is fabricated for measuring transit time of a fluid flow using chirp signals, and a pneumotachometer with annular ring transducers is also disclosed.

摘要翻译： 提供了一种用于制造用于确定流体流速度的环形换能器的方法。 制造了一种新颖而精确的流量测量系统，用于测量使用啁啾信号的流体流动时间，并且还公开了一种具有环形环形换能器的气动测速计。

公开(公告)号：US5642375A

公开(公告)日：1997-06-24

申请号：US548787

申请日：1995-10-26

申请人： David A. King ,  Richard J. Pittaro

发明人： David A. King ,  Richard J. Pittaro

IPC分类号： H01S3/082 ,  H01S3/109 ,  H01S5/06 ,  H01S5/065 ,  H01S5/14

CPC分类号： H01S3/109 ,  H01S3/082 ,  H01S5/141 ,  H01S5/065 ,  H01S5/142

摘要： A laser system capable of providing light of high intensity is disclosed. This system includes a laser gain medium and three reflectors. A first reflector and a second reflector spaced from the first reflector define a laser cavity that contains the laser gain medium. The second reflector has a reflectivity (R.sub.2) larger than the reflectivity (R.sub.1) of the first reflector such that light emitted from the laser gain medium resonates in the laser cavity. A third reflector having a reflectivity (R.sub.3) larger than the reflectivity of the first reflector (R.sub.1) is spaced from the second reflector to define a resonant cavity external to the laser cavity. Light passes from the laser cavity to resonate in the external resonant cavity. Part of the light passes from the external resonant cavity to the laser cavity to optically lock the laser gain medium.

摘要翻译： 公开了一种能够提供高强度光的激光系统。 该系统包括激光增益介质和三个反射器。 与第一反射器间隔开的第一反射器和第二反射器限定包含激光增益介质的激光腔。 第二反射器具有大于第一反射器的反射率（R1）的反射率（R2），使得从激光增益介质发射的光在激光腔中共振。 具有比第一反射器（R1）的反射率大的反射率（R3）的第三反射器与第二反射器间隔开以限定激光腔外部的谐振腔。 光通过激光腔，在外部谐振腔谐振。 部分光从外部谐振腔传递到激光腔，以光学锁定激光增益介质。