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公开(公告)号:US08748440B2
公开(公告)日:2014-06-10
申请号:US13247328
申请日:2011-09-28
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号: C07D409/12 , C07D239/90 , C07D239/91 , C07D413/12
摘要: Compounds, pharmaceutical compositions and methods for modulating the activity of nuclear receptors are provided. In particular, quinazolinones are provided for modulating the activity of farnesoid X receptor (FXR) and/or orphan nuclear receptors.
摘要翻译: 提供了用于调节核受体活性的化合物,药物组合物和方法。 特别地,提供喹唑啉酮用于调节法呢酯X受体(FXR)和/或孤儿核受体的活性。
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公开(公告)号:US07115640B2
公开(公告)日:2006-10-03
申请号:US10717049
申请日:2003-11-18
申请人: Richard Martin , Brenton T Flatt , Jeffrey D Kahl , Tie-Lin Wang
发明人: Richard Martin , Brenton T Flatt , Jeffrey D Kahl , Tie-Lin Wang
IPC分类号: A61K31/425 , C07D277/62 , C07D277/04
CPC分类号: C07D277/20 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/64 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. In certain embodiments, the compounds are thiazolidinone derivatives.
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