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公开(公告)号:US07414063B2
公开(公告)日:2008-08-19
申请号:US10547969
申请日:2004-03-25
申请人: Rima Salim Al-Awar , David Anthony Barda , Albert Gerard Dee , Kenneth James Henry, Jr. , Sajan Joseph , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett , Carmen Somoza
发明人: Rima Salim Al-Awar , David Anthony Barda , Albert Gerard Dee , Kenneth James Henry, Jr. , Sajan Joseph , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett , Carmen Somoza
IPC分类号: C07D217/02 , A61K31/47
CPC分类号: C07D401/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12 , C07D413/02 , C07D413/12
摘要: The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译: 本发明涉及式(I)化合物:作为AKT活性的抑制剂,其可用于治疗易感性肿瘤和病毒感染。
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2.7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B) 失效
标题翻译: 作为akt(蛋白激酶B)的抑制剂的7-苯基 - 异喹啉-5-磺酰基氨基衍生物公开(公告)号:US07449477B2
公开(公告)日:2008-11-11
申请号:US10595798
申请日:2004-11-22
申请人: David Anthony Barda , Kenneth James Henry, Jr. , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Enrico Richett
发明人: David Anthony Barda , Kenneth James Henry, Jr. , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Enrico Richett
IPC分类号: C07D217/22 , C07D401/12 , A61K31/4725 , A61K31/472
CPC分类号: C04B35/632 , C07D217/02 , C07D217/22 , C07D401/12
摘要: The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译: 本发明涉及作为AKT活性抑制剂的式(I)化合物,其可用于治疗易感性肿瘤和病毒感染。
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公开(公告)号:US07084170B2
公开(公告)日:2006-08-01
申请号:US10490935
申请日:2002-10-15
申请人: Cora Sue Grossman , Philip Arthur Hipskind , Ho-Shen Lin , Karen Lynn Lobb , Beatriz Lopez de Uralde Garmendia , Jose Eduardo Lopez , Mary Margaret Mader , Michael Enrico Richett , Chuan Shih , Alfonso De Dios
发明人: Cora Sue Grossman , Philip Arthur Hipskind , Ho-Shen Lin , Karen Lynn Lobb , Beatriz Lopez de Uralde Garmendia , Jose Eduardo Lopez , Mary Margaret Mader , Michael Enrico Richett , Chuan Shih , Alfonso De Dios
IPC分类号: A61K31/381 , C07D333/34
CPC分类号: C07D277/36 , C07D333/34 , C07D333/38
摘要: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
摘要翻译: 本发明提供下式的抗肿瘤化合物和抗肿瘤方法。
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公开(公告)号:US06448422B1
公开(公告)日:2002-09-10
申请号:US09609871
申请日:2000-07-03
申请人: Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Richard Waltz Harper , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett
发明人: Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Richard Waltz Harper , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett
IPC分类号: C07F902
摘要: This application relates to a novel compound of formula I, as defined herein, processes and intermediates for its preparation and the use of the compound of formula I as a substrate for a pharmaceutical screen.
摘要翻译: 本申请涉及如本文定义的式I的新化合物,其制备方法和中间体以及式I化合物作为药物筛选的底物的用途。
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公开(公告)号:US07217727B2
公开(公告)日:2007-05-15
申请号:US10544908
申请日:2004-03-25
申请人: Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Ho-Shen Lin , Jose Eduardo Lopez , Marian Kazimierz Mosior , Michael Enrico Richett
发明人: Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Ho-Shen Lin , Jose Eduardo Lopez , Marian Kazimierz Mosior , Michael Enrico Richett
IPC分类号: A61K31/423 , C07D261/20
CPC分类号: C07D261/20
摘要: A novel class of 3-oxo-3H-benzo[d]isoxazole carboxamide compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase mediated diseases.
摘要翻译: 公开了一类新的3-氧代-3H-苯并[d]异恶唑甲酰胺化合物,同时使用这些化合物抑制肝脂肪酶和/或内皮脂肪酶活性用于治疗,改善或预防肝脂肪酶和/或内皮脂肪酶 介导的疾病。
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6.Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors 失效
标题翻译: 苯并异噻唑-3-酮羧酸酰胺作为磷脂酶抑制剂公开(公告)号:US07595403B2
公开(公告)日:2009-09-29
申请号:US10550006
申请日:2004-03-25
申请人: Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Ho-Shen Lin , Jose Eduardo Lopez , Marian Kazimierz Mosior , Michael Enrico Richett
发明人: Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Ho-Shen Lin , Jose Eduardo Lopez , Marian Kazimierz Mosior , Michael Enrico Richett
IPC分类号: A61K31/428 , C07D275/04
CPC分类号: C07D275/04 , C07D417/12
摘要: A novel class of benzisothiazole-3(2H)-one compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase mediated diseases. (I)
摘要翻译: 公开了一类新的苯并异噻唑-3(2H) - 酮化合物,以及这些化合物用于抑制肝脂肪酶和/或内皮脂肪酶活性用于治疗,改善或预防肝脂肪酶和/或内皮脂肪酶介导的疾病。 (一世)
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公开(公告)号:US07250430B2
公开(公告)日:2007-07-31
申请号:US11447457
申请日:2006-06-06
申请人: Cora Sue Grossman , Philip Arthur Hipskind , Ho-Shen Lin , Karen Lynn Lobb , Beatriz Lopez de Uralde Garmendia , Jose Eduardo Lopez , Mary Margaret Mader , Michael Enrico Richett , Chuan Shih , Alfonso De Dios
发明人: Cora Sue Grossman , Philip Arthur Hipskind , Ho-Shen Lin , Karen Lynn Lobb , Beatriz Lopez de Uralde Garmendia , Jose Eduardo Lopez , Mary Margaret Mader , Michael Enrico Richett , Chuan Shih , Alfonso De Dios
IPC分类号: A61K31/381 , A61K31/426
CPC分类号: C07D277/36 , C07D333/34 , C07D333/38
摘要: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
摘要翻译: 本发明提供下式的抗肿瘤化合物和抗肿瘤方法。
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公开(公告)号:US20070043040A1
公开(公告)日:2007-02-22
申请号:US10547969
申请日:2004-03-25
申请人: Rima Al-Awar , David Barda , Albert Dee , Kenneth Henry Jr , Sajan Joseph , Ho-Shen Lin , Jose Lopez , Michael Richett , Carmen Somoza
发明人: Rima Al-Awar , David Barda , Albert Dee , Kenneth Henry Jr , Sajan Joseph , Ho-Shen Lin , Jose Lopez , Michael Richett , Carmen Somoza
IPC分类号: A61K31/5377 , A61K31/4709 , C07D413/02 , C07D401/02
CPC分类号: C07D401/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12 , C07D413/02 , C07D413/12
摘要: The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译: 本发明涉及式(I)化合物:作为AKT活性抑制剂,其可用于治疗易感性肿瘤和病毒感染。
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9.[4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases 失效
标题翻译: [4-(苯并[B]噻吩-2-基)嘧啶-2-基] - 衍生物作为Ikk-β抑制剂治疗癌症和炎性疾病公开(公告)号:US20080306082A1
公开(公告)日:2008-12-11
申请号:US12093024
申请日:2006-11-15
申请人: Karl Robert Dahnke , Ho-Shen Lin , Michael Enrico Richett , Chuan Shih , Q May Wang , Bo Zhang
发明人: Karl Robert Dahnke , Ho-Shen Lin , Michael Enrico Richett , Chuan Shih , Q May Wang , Bo Zhang
IPC分类号: C07D409/04 , A61K31/506 , A61K31/496 , A61P11/00 , C07D409/14 , A61P19/02 , A61P35/00 , A61P29/00
CPC分类号: C07D409/04
摘要: The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.
摘要翻译: 本发明提供式I化合物:可用于治疗癌症和炎性疾病。
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公开(公告)号:US06974831B2
公开(公告)日:2005-12-13
申请号:US10450741
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
IPC分类号: A61K31/403 , A61P1/00 , A61P1/18 , A61P11/02 , A61P11/06 , A61P11/08 , A61P17/02 , A61P19/02 , A61P29/00 , A61P31/04 , A61P43/00 , C07D209/60 , C07D209/70 , C07D409/10 , A61K31/404 , C07D209/56
CPC分类号: C07D209/70 , C07D209/60 , C07D409/10
摘要: A novel class of cycloalkyl fused indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 公开了一类新型的环烷基稠合吲哚化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎症性疾病如败血性休克的用途。
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