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公开(公告)号:US07414063B2
公开(公告)日:2008-08-19
申请号:US10547969
申请日:2004-03-25
申请人: Rima Salim Al-Awar , David Anthony Barda , Albert Gerard Dee , Kenneth James Henry, Jr. , Sajan Joseph , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett , Carmen Somoza
发明人: Rima Salim Al-Awar , David Anthony Barda , Albert Gerard Dee , Kenneth James Henry, Jr. , Sajan Joseph , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett , Carmen Somoza
IPC分类号: C07D217/02 , A61K31/47
CPC分类号: C07D401/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12 , C07D413/02 , C07D413/12
摘要: The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译: 本发明涉及式(I)化合物:作为AKT活性的抑制剂,其可用于治疗易感性肿瘤和病毒感染。
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2.7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B) 失效
标题翻译: 作为akt(蛋白激酶B)的抑制剂的7-苯基 - 异喹啉-5-磺酰基氨基衍生物公开(公告)号:US07449477B2
公开(公告)日:2008-11-11
申请号:US10595798
申请日:2004-11-22
申请人: David Anthony Barda , Kenneth James Henry, Jr. , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Enrico Richett
发明人: David Anthony Barda , Kenneth James Henry, Jr. , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Enrico Richett
IPC分类号: C07D217/22 , C07D401/12 , A61K31/4725 , A61K31/472
CPC分类号: C04B35/632 , C07D217/02 , C07D217/22 , C07D401/12
摘要: The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译: 本发明涉及作为AKT活性抑制剂的式(I)化合物,其可用于治疗易感性肿瘤和病毒感染。
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公开(公告)号:US06867198B2
公开(公告)日:2005-03-15
申请号:US10130493
申请日:2000-12-18
申请人: Rima Salim Al-Awar , Kyle Andrew Hecker , James Edward Ray , Jianping Huang , Sajan Joseph , Tiechao Li , Michael Paal , Radhakrishnan Rathnachalam , Chuan Shih , Philip Parker Waid , Xun Zhou , Guoxin Zhu
发明人: Rima Salim Al-Awar , Kyle Andrew Hecker , James Edward Ray , Jianping Huang , Sajan Joseph , Tiechao Li , Michael Paal , Radhakrishnan Rathnachalam , Chuan Shih , Philip Parker Waid , Xun Zhou , Guoxin Zhu
IPC分类号: C07D471/06 , C07D471/22 , C07D487/06 , C07D487/22 , C07D513/06 , C07D513/22 , C07F7/18 , C07H15/252 , A61K31/435 , A61K31/445
CPC分类号: C07D471/06 , C07D487/06 , C07D513/06 , C07F7/1804 , C07H15/252
摘要: The present invention provides selective kinase inhibitors of formula (I)
摘要翻译: 本发明提供了式(I)的选择性激酶抑制剂,
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公开(公告)号:US06743785B2
公开(公告)日:2004-06-01
申请号:US10130801
申请日:2002-05-21
申请人: Rima Salim Al-Awar , Kyle Andrew Hecker , Jianping Huang , Sajan Joseph , James Edward Ray , Philip Parker Waid
发明人: Rima Salim Al-Awar , Kyle Andrew Hecker , Jianping Huang , Sajan Joseph , James Edward Ray , Philip Parker Waid
IPC分类号: C07D40314
CPC分类号: C07D487/22 , C07F7/1804
摘要: The present invention provides selective kinase inhibitors of formula (I).
摘要翻译: 本发明提供式(I)的选择性激酶抑制剂。
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公开(公告)号:US20070043040A1
公开(公告)日:2007-02-22
申请号:US10547969
申请日:2004-03-25
申请人: Rima Al-Awar , David Barda , Albert Dee , Kenneth Henry Jr , Sajan Joseph , Ho-Shen Lin , Jose Lopez , Michael Richett , Carmen Somoza
发明人: Rima Al-Awar , David Barda , Albert Dee , Kenneth Henry Jr , Sajan Joseph , Ho-Shen Lin , Jose Lopez , Michael Richett , Carmen Somoza
IPC分类号: A61K31/5377 , A61K31/4709 , C07D413/02 , C07D401/02
CPC分类号: C07D401/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12 , C07D413/02 , C07D413/12
摘要: The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译: 本发明涉及式(I)化合物:作为AKT活性抑制剂,其可用于治疗易感性肿瘤和病毒感染。
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6.7-Phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b) 失效
标题翻译: 作为akt抑制剂的7-苯基 - 异喹啉-5-磺酰氨基衍生物(蛋氨酸酶b)公开(公告)号:US20070037796A1
公开(公告)日:2007-02-15
申请号:US10595798
申请日:2004-11-22
申请人: David Barda , Kenneth Henry , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Richett
发明人: David Barda , Kenneth Henry , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Richett
IPC分类号: A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4709 , C07D217/22 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号: C04B35/632 , C07D217/02 , C07D217/22 , C07D401/12
摘要: The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译: 本发明涉及作为AKT活性抑制剂的式(I)化合物,其可用于治疗易感性肿瘤和病毒感染。
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公开(公告)号:US07700628B2
公开(公告)日:2010-04-20
申请号:US11719415
申请日:2005-11-10
申请人: Ankush Baburao Argade , Theodore Goodson, Jr. , David Kent Herron , Sajan Joseph , Salvatore Donato Lepore , Angela Lynn Marquart , John Joseph Masters , David Mendel , Leander Merritt , Andrew Michael Ratz , Gerald Floyd Smith , Anne Louise Tebbe , Michael Robert Wiley , Ying Kwong Yee
发明人: Ankush Baburao Argade , Theodore Goodson, Jr. , David Kent Herron , Sajan Joseph , Salvatore Donato Lepore , Angela Lynn Marquart , John Joseph Masters , David Mendel , Leander Merritt , Andrew Michael Ratz , Gerald Floyd Smith , Anne Louise Tebbe , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: C07D413/10 , C07D413/14 , C07D401/10 , C07D401/02 , C07D401/14 , C07D401/12 , C07D409/10 , C07D243/08 , C07D213/75 , A61K31/381 , A61K31/4402 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/551
CPC分类号: C07D211/46 , C07C229/38 , C07D213/75 , C07D295/192 , C07D333/38 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/12
摘要: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
摘要翻译: 本申请涉及如本文所定义的式(I)化合物(或其化合物或前药的药学上可接受的盐),其药物组合物及其作为因子Xa和/或凝血酶抑制剂的用途,以及 其制备方法及其中间体。 式(I)化合物的实例是(a)。
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公开(公告)号:US20090227566A1
公开(公告)日:2009-09-10
申请号:US11719415
申请日:2005-11-10
申请人: Ankush Baburao Argade , Theodore Goodson, JR. , David Kent Herron , Sajan Joseph , Salvatore Donato Lepore , Angela Lynn Marquart , John Joseph Masters , David Mendel , Leander Merritt , Andrew Michael Ratz , Gerald Floyd Smith , Anne Lousie Tebbe , Michael Robert Wiley , Ying Kwong Yee
发明人: Ankush Baburao Argade , Theodore Goodson, JR. , David Kent Herron , Sajan Joseph , Salvatore Donato Lepore , Angela Lynn Marquart , John Joseph Masters , David Mendel , Leander Merritt , Andrew Michael Ratz , Gerald Floyd Smith , Anne Lousie Tebbe , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: A61K31/551 , A61K31/5377 , A61K31/445 , C07D243/08 , C07D413/12 , C07D401/12 , C07D211/98
CPC分类号: C07D211/46 , C07C229/38 , C07D213/75 , C07D295/192 , C07D333/38 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/12
摘要: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
摘要翻译: 本申请涉及如本文所定义的式(I)化合物(或其化合物或前药的药学上可接受的盐),其药物组合物及其作为因子Xa和/或凝血酶抑制剂的用途,以及 其制备方法及其中间体。 式(I)化合物的实例是(a)。
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公开(公告)号:US06716855B2
公开(公告)日:2004-04-06
申请号:US10374124
申请日:2003-02-25
申请人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: A61K3144
CPC分类号: C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号:US08148387B2
公开(公告)日:2012-04-03
申请号:US12611139
申请日:2009-11-03
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04 , C07D473/34
摘要: The present invention provides AKT and p70 S6 kinase inhibitors of the formula: The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and methods of using compounds of Formula I.
摘要翻译: 本发明提供下式的AKT和p70 S6激酶抑制剂:本发明还提供包含式I化合物的药物组合物,式I化合物的用途和使用式I化合物的方法。
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