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14 条记录 (耗时 0.024 秒)

    Bacteriohopanetetrol and related compounds useful for modulation of lipoxygenase activity and anti-inflammatory applications
    2.
    发明授权
    Bacteriohopanetetrol and related compounds useful for modulation of lipoxygenase activity and anti-inflammatory applications 失效
    用于调节脂氧合酶活性和抗炎应用的细菌素乙内酯和相关化合物

    公开(公告)号：US06177415B1

    公开(公告)日：2001-01-23

    申请号：US08844631

    申请日：1997-04-21

    申请人： Robert A. Moreau ,  Kevin B. Hicks

    发明人： Robert A. Moreau ,  Kevin B. Hicks

    IPC分类号： A61K3156

    CPC分类号： A61K31/58 ,  A61K31/56

    摘要： The arachidonic acid-metabolizing hopanoid tetrahydroxybacteriohopane (THBH) was isolated from Zymomonas mobilis and was found to inhibit soybean 15-lipoxygenase, and thus lipoxin biosynthesis, with an IC50 of about 10 &mgr;M. The activities of two other arachidonic acid-metabolizing enzymes, human 5-lipoxygenase (involved in prostaglandin biosynthesis) and prostaglandin H synthase, were unaffected by THBH. Subsequent studies showed that THBH was effective as an anti-inflammatory agent in topical applications.

    摘要翻译： 从运动发酵单胞菌中分离出花生四烯酸代谢类似的五羟基菌核桃（THBH），发现抑制大豆15脂氧合酶，从而抑制脂氧素生物合成，IC50约为10μM。 两种其他花生四烯酸代谢酶，人5-脂氧合酶（参与前列腺素生物合成）和前列腺素H合成酶的活性不受THBH的影响。 随后的研究表明，泰铢在局部应用中作为抗炎剂有效。

    Continuous process for the production of lactulose from lactose using boric acid as a complexsation agent
    3.
    发明授权
    Continuous process for the production of lactulose from lactose using boric acid as a complexsation agent 失效
    使用硼酸作为络合剂从乳糖生产乳果糖的连续方法

    公开(公告)号：US5895814A

    公开(公告)日：1999-04-20

    申请号：US510065

    申请日：1995-08-01

    申请人： Michael F. Kozempel ,  Kevin B. Hicks ,  Michael J. Kurantz ,  James C. Craig

    发明人： Michael F. Kozempel ,  Kevin B. Hicks ,  Michael J. Kurantz ,  James C. Craig

    IPC分类号： C07H3/04 ,  C07H1/00

    CPC分类号： C07H3/04

    摘要： A method is described for the preparation of lactulose by isomerizing lactose to lactulose, followed by complexing lactulose to boric acid. The isomerization reaction is carried out in alkaline solution, and it is followed by splitting the lactulose-borate complex in acidic solution and separating the two components. Separation is achieved by crystallizing boric acid, filtering the crystals out of the product mixture, evaporating the product mixture to form a concentrate, recirculating the concentrate to the crystallization step where it is mixed with fresh reaction mixture in order to provide volume and nuclei for the crystallization of the boric acid in the reaction mixture, then passing the resulting mixture through another filtration step followed by an additional separation step by column chromatography.

    摘要翻译： 描述了通过将乳糖异构化为乳果糖来制备乳果糖的方法，然后将乳果糖络合至硼酸。 异构化反应在碱性溶液中进行，然后在乳酸溶液中分离乳果糖 - 硼酸盐络合物并分离两种组分。 通过结晶硼酸，将产物混合物中的晶体过滤，蒸发产物混合物以形成浓缩物，将浓缩物再循环到结晶步骤，在其中与新鲜的反应混合物混合以提供体积和核 在反应混合物中结晶硼酸，然后将所得混合物通过另一过滤步骤，然后通过柱色谱法进行另外的分离步骤。

    Process for preserving raw fruit and vegetable juices using cyclodextrins and compositions thereof
    4.
    发明授权
    Process for preserving raw fruit and vegetable juices using cyclodextrins and compositions thereof 失效
    使用环糊精及其组合物保存生果汁和蔬菜汁的方法

    公开(公告)号：US4975293A

    公开(公告)日：1990-12-04

    申请号：US141857

    申请日：1988-01-11

    申请人： Kevin B. Hicks ,  Gerald M. Sapers ,  Paul A. Seib

    发明人： Kevin B. Hicks ,  Gerald M. Sapers ,  Paul A. Seib

    IPC分类号： A23B7/154 ,  A23B7/155 ,  A23B7/16 ,  A23L2/42 ,  A23L2/44 ,  A23L2/80

    CPC分类号： A23L2/44 ,  A23B7/154 ,  A23B7/155 ,  A23B7/16 ,  A23L2/42 ,  A23L2/80

    摘要： A process of inhibiting enzymatic browning in raw fruit and vegetable juices comprising treating the juices with cyclodextrins, individually or in combination. Soluble cyclodextrins treatments may be added directly to the juices. In the alternative, isoluble cyclodextrins may be used as a packing in a column or in a batch treatment process. In effect, treatments of the invention tend to limit the extent or rate of enzymatic browning in the affected juices. Also disclosed are novel browning inhibiting compositions which are effective in controlling enzymatic browning in raw fruit and vegetable juices. The novel compositions are potential alternatives for presently used sulfites.

    摘要翻译： 抑制生水果和蔬菜汁中的酶促褐变的方法，包括单独或组合地用环糊精处理果汁。 可溶性环糊精处理可以直接添加到果汁中。 在替代方案中，可将不溶性环糊精用作柱中的填料或间歇处理工艺。 实际上，本发明的处理倾向于限制受影响的果汁中酶促褐变的程度或速率。 还公开了新鲜的抑制褐变的组合物，其有效地控制生水果和蔬菜汁中的酶促褐变。 新型组合物是目前使用的亚硫酸盐的潜在替代物。

    Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
    5.
    发明授权
    Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making 有权
    由天然聚合物和合成聚合物制成的多孔聚合物基质和任选的至少一种阳离子和制备方法

    公开(公告)号：US08080590B1

    公开(公告)日：2011-12-20

    申请号：US12157301

    申请日：2008-06-09

    申请人： LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

    发明人： LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

    IPC分类号： C08B37/00

    CPC分类号： C08B37/0045 ,  A61L27/26 ,  A61L27/56 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/05 ,  C08J2367/04 ,  C08J2405/00 ,  C08L5/06 ,  C08L67/04 ,  C08L5/04 ,  C08L2666/18 ,  C08L2666/26

    摘要： A porous polymeric matrix containing at least one natural polymer and at least one synthetic polymer and optionally at least one cation. Furthermore, a method of making a porous polymeric matrix involving mixing at least one natural polymer and inorganic salts with a solution comprising at least one solvent and at least one synthetic polymer to form a slurry, casting the slurry in a mold and removing the solvent to form solid matrices, immersing the solid matrices in deionized water to allow natural polymer cross-linking and pore creation to occur simultaneously, and drying the matrices to create a porous polymeric matrix; wherein the matrix contains a cation. Also, a method of making a porous polymeric matrix, involving mixing at least one natural polymer in an aqueous solvent and mixing at least one synthetic polymer in an organic solvent, combining the mixtures and casting in a mold, and separately removing said aqueous solvent and said organic solvent to form a porous polymeric matrix; wherein the porous polymeric matrix does not contain a cation.

    摘要翻译： 含有至少一种天然聚合物和至少一种合成聚合物和任选的至少一种阳离子的多孔聚合物基质。 此外，制备多孔聚合物基质的方法包括将至少一种天然聚合物和无机盐与包含至少一种溶剂和至少一种合成聚合物的溶液混合以形成浆料，将浆料浇铸到模具中并除去溶剂 形成固体基质，将固体基质浸入去离子水中以允许天然聚合物交联和孔产生同时发生，并干燥基质以产生多孔聚合物基质; 其中所述基质含有阳离子。 而且，制备多孔聚合物基质的方法，包括在水性溶剂中混合至少一种天然聚合物并在有机溶剂中混合至少一种合成聚合物，将该混合物和铸件混合在模具中，并分别除去所述水性溶剂和 所述有机溶剂形成多孔聚合物基质; 其中所述多孔聚合物基质不含阳离子。

    Isolation of hemicellulose from corn fiber
    6.
    发明授权
    Isolation of hemicellulose from corn fiber 失效
    从玉米纤维中分离半纤维素

    公开(公告)号：US6147206A

    公开(公告)日：2000-11-14

    申请号：US39153

    申请日：1998-03-13

    申请人： Landis W. Doner ,  Gregory A. Sweeney ,  Kevin B. Hicks

    发明人： Landis W. Doner ,  Gregory A. Sweeney ,  Kevin B. Hicks

    IPC分类号： C08B37/14 ,  C08B37/00 ,  C08H8/00

    CPC分类号： C08B37/006 ,  C08B37/0057

    摘要： This invention pertains to a high yield process for producing high quality corn fiber gum by hydrogen peroxide treatment of corn fiber during alkaline extraction and/or after obtaining the alkaline extract of milled corn fiber. This process comprises the steps:a) mixing corn fiber with an alkaline solution to form a slurry and extract hemicellulose;b) treating the slurry with hydrogen peroxide at a pH of about 10.0 to 12.5; andc) separating out the insoluble fractions from the corn fiber slurry to yield corn fiber gum.The corn fiber gum produced by this process is highly soluble in water and provides low viscosity solutions which are nearly devoid of color over a wide pH range. The corn fiber gum lacks objectionable flavor and aroma. The corn fiber gum is useful for a variety of applications, including film formation and to thicken, emulsify, stabilize and/or extend aqueous solutions and suspensions.

    摘要翻译： 本发明涉及在碱性提取期间和/或在获得碾磨的玉米纤维的碱性提取物之后通过过氧化氢处理玉米纤维生产高质量玉米纤维胶的高产率方法。 该方法包括以下步骤：a）将玉米纤维与碱性溶液混合以形成浆料并提取半纤维素; b）用pH为约10.0至12.5的过氧化氢处理浆料; 和c）从玉米纤维浆液中分离出不溶性部分以得到玉米纤维胶。 通过该方法生产的玉米纤维胶高溶于水，并提供在宽pH范围内几乎无颜色的低粘度溶液。 玉米纤维胶没有令人反感的味道和香气。 玉米纤维胶可用于各种应用，包括成膜和增稠，乳化，稳定和/或延伸水溶液和悬浮液。

    Compositions containing poly(lactic acid), bacteriocin(s), plasticizers(s), and optionally pore forming agent(s), and methods or making
    8.
    发明授权
    Compositions containing poly(lactic acid), bacteriocin(s), plasticizers(s), and optionally pore forming agent(s), and methods or making 有权
    包含聚（乳酸），细菌素，增塑剂和任选的成孔剂的组合物，以及方法或制备

    公开(公告)号：US08268905B1

    公开(公告)日：2012-09-18

    申请号：US12583110

    申请日：2009-08-14

    申请人： LinShu Liu ,  David R. Coffin ,  Kevin B. Hicks ,  Zhonglin T. Jin

    发明人： LinShu Liu ,  David R. Coffin ,  Kevin B. Hicks ,  Zhonglin T. Jin

    IPC分类号： C08J9/00

    CPC分类号： C08L67/04 ,  C08J3/203 ,  C08J9/0023 ,  C08J9/26 ,  C08J2201/0422 ,  C08J2201/0446 ,  C08J2201/0464 ,  C08J2367/04 ,  C08J2489/00 ,  C08K5/0058 ,  C08K5/103 ,  C08L89/00

    摘要： A composition containing poly(lactic acid), at least one bacteriocin (e.g., nisin, generally in the form of Nisaplin®), and at least one plasticizer (e.g., lactic acid, lactide, triacetin, glycerol triacetate), and optionally at least one pore forming agent. A method of making the composition, involving mixing about 100% of the total of the poly(lactic acid), about 50% to about 90% of the total of the at least one plasticizer, and optionally at least one pore forming agent at a first temperature of about 150° to about 170° C. to form a mixture, cooling the mixture to a second temperature of about 115° to about 125° C., adding at least one bacteriocin and about 10% to about 50% of the total of the at least one plasticizer and the remainder of the total of the poly(lactic acid) to the mixture and mixing to form the composition.

    摘要翻译： 含有聚（乳酸），至少一种细菌素（例如通常为Nisaplin的形式的乳链菌肽）和至少一种增塑剂（例如乳酸，丙交酯，甘油三乙酸酯，甘油三乙酸酯）和任选地至少 一种成孔剂。 一种制备该组合物的方法，包括混合约100％的聚（乳酸），约50％至约90％的至少一种增塑剂和任选的至少一种成孔剂 第一温度为约150℃至约170℃以形成混合物，将混合物冷却至约115℃至约125℃的第二温度，加入至少一种细菌素和约10％至约50％的 将总共​​至少一种增塑剂和剩余的聚（乳酸）的总量混合并混合以形成组合物。

    Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
    10.
    发明授权
    Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making 失效
    由天然聚合物和合成聚合物制成的多孔聚合物基质和任选的至少一种阳离子和制备方法

    公开(公告)号：US07446131B1

    公开(公告)日：2008-11-04

    申请号：US11058034

    申请日：2005-02-15

    申请人： LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

    发明人： LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

    IPC分类号： C08B37/00

    CPC分类号： C08B37/0045 ,  A61L27/26 ,  A61L27/56 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/05 ,  C08J2367/04 ,  C08J2405/00 ,  C08L5/06 ,  C08L67/04 ,  C08L5/04 ,  C08L2666/18 ,  C08L2666/26

    摘要： A porous polymeric matrix containing at least one natural polymer and at least one synthetic polymer and optionally at least one cation. Furthermore, a method of making a porous polymeric matrix involving mixing at least one natural polymer and inorganic salts with a solution comprising at least one solvent and at least one synthetic polymer to form a slurry, casting the slurry in a mold and removing the solvent to form solid matrices, immersing the solid matrices in deionized water to allow natural polymer cross-linking and pore creation to occur simultaneously, and drying the matrices to create a porous polymeric matrix; wherein the matrix contains a cation. Also, a method of making a porous polymeric matrix, involving mixing at least one natural polymer in an aqueous solvent and mixing at least one synthetic polymer in an organic solvent, combining the mixtures and casting in a mold, and separately removing said aqueous solvent and said organic solvent to form a porous polymeric matrix; wherein the porous polymeric matrix does not contain a cation.

    摘要翻译： 含有至少一种天然聚合物和至少一种合成聚合物和任选的至少一种阳离子的多孔聚合物基质。 此外，制备多孔聚合物基质的方法包括将至少一种天然聚合物和无机盐与包含至少一种溶剂和至少一种合成聚合物的溶液混合以形成浆料，将浆料浇铸到模具中并除去溶剂 形成固体基质，将固体基质浸入去离子水中以允许天然聚合物交联和孔产生同时发生，并干燥基质以产生多孔聚合物基质; 其中所述基质含有阳离子。 而且，制备多孔聚合物基质的方法，包括在水性溶剂中混合至少一种天然聚合物并在有机溶剂中混合至少一种合成聚合物，将该混合物和铸件混合在模具中，并分别除去所述水性溶剂和 所述有机溶剂形成多孔聚合物基质; 其中所述多孔聚合物基质不含阳离子。