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1.
公开(公告)号:US08377248B2
公开(公告)日:2013-02-19
申请号:US12816568
申请日:2010-06-16
CPC分类号: B29C33/448 , B29C33/3842 , B29C70/443 , B29C70/446 , B29L2031/737
摘要: A system and method for forming a hollow, complex, monolithic composite part. Composite material may be placed around the mandrel, then an internal impermeable membrane may be placed into and/or through tunnels formed in the mandrel. Next, an external impermeable membrane may be placed around the composite material and sealed against itself and the internal impermeable membrane such that the mandrel and the composite material are both contained in an airtight manner between the internal and external impermeable membranes. Air may then be removed from within the sealed impermeable membranes, compressing the impermeable membranes against the mandrel and/or the composite material. The consolidated composite material may be hardened to form the composite part. Finally, the impermeable membrane may be removed from around the hollow composite part and from within the mandrel, followed by removal of the mandrel from within the composite part by breaking it up into smaller pieces.
摘要翻译: 一种用于形成中空复合整体复合材料部件的系统和方法。 可以将复合材料放置在心轴周围,然后将内部不可渗透的膜放置在形成在心轴中的通道中和/或穿过该通孔中。 接下来,外部不可渗透的膜可以放置在复合材料周围并且被密封抵抗其自身和内部不可渗透的膜,使得心轴和复合材料都以内部和外部不可渗透膜之间的气密方式包含。 然后可以从密封的不可渗透膜中除去空气,将不透水膜压靠在心轴和/或复合材料上。 固结的复合材料可以被硬化以形成复合部件。 最后,不可渗透的膜可以从中空复合材料部件周围和芯棒内部移除,然后通过将其分解成较小的部件从复合材料部件中除去心轴。
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2.
公开(公告)号:US20110308711A1
公开(公告)日:2011-12-22
申请号:US12816568
申请日:2010-06-16
IPC分类号: B29C53/50
CPC分类号: B29C33/448 , B29C33/3842 , B29C70/443 , B29C70/446 , B29L2031/737
摘要: A system and method for forming a hollow, complex, monolithic composite part. Composite material may be placed around the mandrel, then an internal impermeable membrane may be placed into and/or through tunnels formed in the mandrel. Next, an external impermeable membrane may be placed around the composite material and sealed against itself and the internal impermeable membrane such that the mandrel and the composite material are both contained in an airtight manner between the internal and external impermeable membranes. Air may then be removed from within the sealed impermeable membranes, compressing the impermeable membranes against the mandrel and/or the composite material. The consolidated composite material may be hardened to form the composite part. Finally, the impermeable membrane may be removed from around the hollow composite part and from within the mandrel, followed by removal of the mandrel from within the composite part by breaking it up into smaller pieces.
摘要翻译: 一种用于形成中空复合整体复合材料部件的系统和方法。 可以将复合材料放置在心轴周围,然后将内部不可渗透的膜放置在形成在心轴中的通道中和/或穿过该通孔中。 接下来,外部不可渗透的膜可以放置在复合材料周围并且被密封抵抗其自身和内部不可渗透的膜,使得心轴和复合材料都以内部和外部不可渗透膜之间的气密方式包含。 然后可以从密封的不可渗透膜中除去空气,将不透水膜压靠在心轴和/或复合材料上。 固结的复合材料可以被硬化以形成复合部件。 最后,不可渗透的膜可以从中空复合材料部件周围和芯棒内部移除,然后通过将其分解成较小的部件从复合材料部件中除去心轴。
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公开(公告)号:US07417068B2
公开(公告)日:2008-08-26
申请号:US10964831
申请日:2004-10-15
申请人: David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark
发明人: David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark
IPC分类号: A61K31/341 , C07D307/34
CPC分类号: C07D307/68
摘要: A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii)an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
摘要翻译: 式(I)化合物或其盐,溶剂合物和化学保护形式,其中R 2和R 5中的一个为:(i)H或任选地 取代的C 1-4烷基; 或(ii)任选取代的C 5-7芳基; R 2和R 5中的另一个是另一个基团; m和n可以是0或1,m + n = 1或2 R N是H或任选取代的C 1-4烷基R 3, SUP>是:(i)羧基; (ii)式(II)的基团:(iii)式(III)的基团:其中R是任选取代的C 1-7烷基,C 5〜20 其中R 3,N 3和R 4各自独立地选自任选取代的C 1 -C 6芳基或NR N 3 N, 1-4个C 1-4烷基; 或(iv)四唑-5-基。
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公开(公告)号:US07326732B2
公开(公告)日:2008-02-05
申请号:US11055724
申请日:2005-02-11
申请人: Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark , David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Mark Richard Ashton , Edward Andrew Boyd , Shirley Ann Brunton
发明人: Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark , David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Mark Richard Ashton , Edward Andrew Boyd , Shirley Ann Brunton
IPC分类号: C07C233/65 , C07D257/04 , A61K31/41 , A61K31/164
CPC分类号: C07D213/81 , C07C233/75 , C07C233/81 , C07C235/84 , C07D233/90 , C07D257/04 , C07D277/24 , C07D277/26 , C07D277/56 , C07D307/46 , C07D307/68 , C07D307/91 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要: A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20 alkyl group; A is selected from the group consisting of: wherein X and Y are selected from the group consisting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O, and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; R3 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R4 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R6 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; D is selected from: B is selected from the group consisting of: where RN′ is selected from H and C1-4 alkyl; where one of RP3 and RP4 is —Cm alkylene-R2 and the other of RP3 and RP4 is H, m and n can be 0 or 1, and m+n=1 or 2; and additionally when RP3 is —Cm alkylene-R2, m can also be 2 or 3, and m+n=1, 2, 3 or 4, and when R2 is tetrazol-5-yl, m+n may be 0; or where one of RP3 and RP4 is —O—CH2—R2, and the other of RP3 and RP4 is H, n is 0; RN is H or optionally substituted C1-4 alkyl; R2 is either: —CO2H (carboxy); —CONH2; —CH2—OH; or tetrazol-5-yl.
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公开(公告)号:US20100130556A1
公开(公告)日:2010-05-27
申请号:US12063421
申请日:2006-08-09
申请人: Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark , David Edward Clark , Shirley Ann Brunton , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Mark Richard Ashton , Edward Andrew Boyd
发明人: Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark , David Edward Clark , Shirley Ann Brunton , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Mark Richard Ashton , Edward Andrew Boyd
IPC分类号: A61K31/443 , C07C249/00 , A61K31/195 , C07C229/40 , C07D307/02 , A61K31/341 , C07D405/12 , C07D263/56 , A61K31/423
CPC分类号: C07C233/81 , C07C257/18 , C07D213/70 , C07D263/57 , C07D307/42 , C07D307/54 , C07D307/68 , C07D307/91 , C07D405/12
摘要: A compound of formula (III): or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20alkyl group; L′ is a single bond, —O— or —C(═O)—; A is selected from the group consisting of: formulae (i) (ii) (iii) wherein X and Y are selected from the group consisting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O, and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; D is selected from: formulae (i) (ii) (iii) (iv) (v) (vii) (viii) (ix) B is selected from the group consisting of: formulae (A) (B) where RP6 is selected from fluoro and chloro; and R2 is either: (i) —CO2H; (ii) —CONH2; (iii) —CH2—OH; or (iv) tetrazol-5-yl.
摘要翻译: 式(III)化合物或其盐,溶剂化物和化学保护形式,其中:R 5为任选取代的C 5-20芳基或C 4-20烷基; L'是单键,-O-或-C(= O) - ; A选自:式(ⅰ)(ⅱ)(ⅲ)其中X和Y选自:O和CR 3; S和CR3; NH和CR3; NH和N; O和N; S和N; N和S; 和N和O,并且其中虚线表示适当位置的双键,并且其中Q为N或CH; D选自:式(i)(ii)(iii)(iv)(v)(vii)(viii)(ix)B选自:其中选择RP6的式(A)(B) 来自氟和氯; 并且R2是:(i)-CO 2 H; (ii)-CONH 2; (ⅲ)-CH 2 -OH; 或(iv)四唑-5-基。
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公开(公告)号:US07662839B2
公开(公告)日:2010-02-16
申请号:US11950613
申请日:2007-12-05
申请人: Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark , David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Mark Richard Ashton , Edward Andrew Boyd , Shirley Ann Brunton
发明人: Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark , David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Mark Richard Ashton , Edward Andrew Boyd , Shirley Ann Brunton
IPC分类号: A61K31/44 , C07D401/02
CPC分类号: C07D213/81 , C07C233/75 , C07C233/81 , C07C235/84 , C07D233/90 , C07D257/04 , C07D277/24 , C07D277/26 , C07D277/56 , C07D307/46 , C07D307/68 , C07D307/91 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要: A compound of formula (I): or a salt, or chemically protected form thereof, wherein: R5 is an optionally substituted phenyl; A is wherein Q is N; R3 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups; R4 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups; R6 is selected from H, F, Cl, and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups; D is selected from: B is selected from the group consisting of: Where RN′ is selected from H and C1-4 alkyl; where one of RP3 and RP4 is —Cm-alkylene-R2 and the other of RP3 and RP4 is H, m and n can be 0 or 1, and m+n=1 or 2; and additionally, when RP3 is —Cm-alkylene-R2, m can also be 2 or 3, and m+n=1, 2, 3 or 4, and when R2 is tetrazol-5-yl, m+n may be 0; or where one of RP3 and RP4 is —O—CH2—R2, and the other of RP3 and RP4 is H, n is 0; RN is H or optionally substituted C1-4 alkyl; R2 is either: (i) —CO2H; (ii) —CONH2; (iii) —CH2—OH; or (iv) tetrazol-5-yl.
摘要翻译: 式(I)化合物或其盐或其化学保护形式,其中:R 5为任选取代的苯基; A是其中Q是N; R 3选自H,F,Cl和任选取代的C 1-4烷基,C 1-4烷氧基,C 5-7芳基和C 5-7芳基-C 1-4烷基; R4选自H,F,Cl和任选取代的C 1-4烷基,C 1-4烷氧基,C 5-7芳基和C 5-7芳基-C 1-4烷基; R 6选自H,F,Cl和任选取代的C 1-4烷基,C 1-4烷氧基,C 5-7芳基和C 5-7芳基-C 1-4烷基; D选自:B选自:其中RN'选自H和C 1-4烷基; 其中RP3和RP4中的一个是-C m - 亚烷基-R2,RP3和RP4中的另一个是H,m和n可以是0或1,m + n = 1或2; 另外当RP3为-C1亚烷基-R2时,m也可以是2或3,m + n = 1,2,3或4,当R 2为四唑-5-基时,m + n可以为0 ; 或RP3和RP4之一为-O-CH2-R2,RP3和RP4中的另一个为H,n为0; RN为H或任选取代的C 1-4烷基; R2是:(i)-CO 2 H; (ii)-CONH 2; (ⅲ)-CH 2 -OH; 或(iv)四唑-5-基。
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公开(公告)号:US20090018150A1
公开(公告)日:2009-01-15
申请号:US10564010
申请日:2004-07-23
申请人: Richard Anthony Borman , Robert Alexander Coleman , Kenneth Lyle Clark , Alexander William Oxford , George Hynd , Janet Ann Archer , Amanda Aley , Neil Victor Harris
发明人: Richard Anthony Borman , Robert Alexander Coleman , Kenneth Lyle Clark , Alexander William Oxford , George Hynd , Janet Ann Archer , Amanda Aley , Neil Victor Harris
IPC分类号: A61K31/505 , C07D239/42 , C07D233/88 , A61K31/4168 , A61K31/421 , C07D263/48 , C07D249/14 , A61K31/4196 , A61P1/00
CPC分类号: C04B35/632 , A61K31/4168 , A61K31/4178 , A61K31/421 , A61K31/4439 , A61K31/505 , A61K31/506 , C07D233/88 , C07D239/47 , C07D239/48 , C07D249/14 , C07D263/48 , C07D401/12 , C07D409/04 , C07D413/10 , C07D417/12
摘要: Compounds of formulae: (I), (II), (IIIa), (IIIb), (IVa) and (IVb): or a pharmaceutically acceptable salt thereof, for use as pharmaceuticals, in particular for the treatment of a condition alleviated by antagonism of a 5-HT2B receptor.
摘要翻译: 用于药物的式(I),(II),(IIIa),(IIIb),(IVa)和(IVb)化合物或其药学上可接受的盐,特别是用于治疗由 拮抗5-HT2B受体。
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公开(公告)号:US20100261760A1
公开(公告)日:2010-10-14
申请号:US12820752
申请日:2010-06-22
申请人: Alexander William Oxford , Richard John Davis , Robert Alexander Coleman , Kenneth Lyle Clark , David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Mark Richard Ashton , Edward Andrew Boyd , Shirley Ann Brunton
发明人: Alexander William Oxford , Richard John Davis , Robert Alexander Coleman , Kenneth Lyle Clark , David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Mark Richard Ashton , Edward Andrew Boyd , Shirley Ann Brunton
IPC分类号: A61K31/4439 , A61K31/4418 , A61K31/381 , A61K31/36 , A61K31/341 , C07D401/12 , C07D213/81 , C07D333/38 , C07D407/10 , C07D307/54 , A61P13/12 , A61P15/00 , A61P27/06 , A61P19/10 , A61P11/06 , A61P37/00
CPC分类号: C07D213/81 , C07C233/75 , C07C233/81 , C07C235/84 , C07D233/90 , C07D257/04 , C07D277/24 , C07D277/26 , C07D277/56 , C07D307/46 , C07D307/68 , C07D307/91 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要: The disclosure provides EP2 receptor agonist compounds and methods for using the compounds for treating conditions which can be alleviated by agonism of an EP2 receptor.
摘要翻译: 本公开提供EP2受体激动剂化合物和使用该化合物治疗可通过EP2受体激动作用缓解的病症的方法。
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公开(公告)号:US07569602B2
公开(公告)日:2009-08-04
申请号:US10576095
申请日:2004-10-15
申请人: David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark
发明人: David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark
IPC分类号: A61K31/341 , C07D307/34
CPC分类号: C07D307/68
摘要: A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii) an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
摘要翻译: 式(I)化合物或其盐,溶剂合物和化学保护形式,其中R 2和R 5之一为:(ⅰ)H或任选取代的C 1-4烷基; 或(ii)任选取代的C 5-7芳基; R2和R5中的另一个为另一组; m和n可以是0或1,并且m + n = 1或2个RN是H或任选取代的C 1-4烷基R 3是:(i)羧基; (ii)式(II)的基团:(iii)式(III)的基团:其中R是任选取代的C 1-7烷基,C 5-20芳基或NRN 3 R N 4,其中RN 3和RN 4独立地选自任选取代的 C 1-4烷基; 或(iv)四唑-5-基。
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公开(公告)号:US20080306117A1
公开(公告)日:2008-12-11
申请号:US12186308
申请日:2008-08-05
申请人: David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark
发明人: David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark
IPC分类号: A61K31/443 , C07D307/34 , A61K31/341 , C07D261/06 , A61P29/00 , A61K31/422 , C07D405/02
CPC分类号: C07D307/68
摘要: A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii) an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
摘要翻译: 式(I)化合物或其盐,溶剂合物和化学保护形式,其中R 2和R 5之一为:(ⅰ)H或任选取代的C 1-4烷基; 或(ii)任选取代的C 5-7芳基; R2和R5中的另一个为另一组; m和n可以是0或1,并且m + n = 1或2个RN是H或任选取代的C 1-4烷基R 3是:(i)羧基; (ii)式(II)的基团:(iii)式(III)的基团:其中R是任选取代的C 1-7烷基,C 5-20芳基或NRN 3 R N 4,其中RN 3和RN 4独立地选自任选取代的 C 1-4烷基; 或(iv)四唑-5-基。
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