公开(公告)号：US08703179B2

公开(公告)日：2014-04-22

申请号：US11302992

申请日：2006-05-11

申请人： RameshBabu Boga ,  Robert B. Johnson

发明人： RameshBabu Boga ,  Robert B. Johnson

IPC分类号： A61K9/127 ,  A01N57/26 ,  A61K31/685 ,  A61K31/565

CPC分类号： A61K9/127 ,  A61K31/565 ,  A61K31/685 ,  A61K2300/00

摘要： A mucosal formulation for administration to mucosal membranes, such as in the mouth, nasal passage, stomach, vagina, etc., is disclosed. The mucosal formulation contains a lipid-pharmaceutical agent complex formed from phospholipids possessing a hydrophobic moiety that orients into a hydrophobic phase and a polar head moiety that orients towards the aqueous phase (i.e., “amphipathic” lipids). When placed in an aqueous medium (e.g., vaginal fluid), the phospholipids form liposomes or other small lipid vesicles (e.g., micelles) that may then be used to deliver pharmaceutical agents into a living organism.

摘要翻译： 公开了用于施用于粘膜的粘膜制剂，例如在口腔，鼻腔，胃，阴道等中。 粘膜制剂包含由具有疏水部分的磷脂形成的脂质 - 药剂复合物，所述疏水部分定位于疏水相和朝向水相定向的极性头部分（即“两亲性”脂质）。 当放置在水性介质（例如阴道液）中时，磷脂形成脂质体或其它小脂质囊泡（例如胶束），然后可以将其用于将药剂递送到生物体内。

公开(公告)号：US07300770B2

公开(公告)日：2007-11-27

申请号：US11117635

申请日：2005-04-28

申请人： Stephanie M. Martin ,  John Gavin MacDonald ,  Allison Salyer Bagwell ,  Jason Lye ,  Robert B. Johnson

发明人： Stephanie M. Martin ,  John Gavin MacDonald ,  Allison Salyer Bagwell ,  Jason Lye ,  Robert B. Johnson

IPC分类号： C12Q1/22

CPC分类号： C12Q1/04 ,  G01N33/528

摘要： An elastomeric article that contains a chromogen that undergoes a detectable change in color in the presence of one or more microbes is provided. For example, in one embodiment, the chromogen is a solvatochromic dye (e.g., Reichardt's dye) that undergoes a color change in the presence of bacteria or other microbes. More specifically, such dyes may respond to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth.

摘要翻译： 提供了包含在一种或多种微生物存在下经历可检测的颜色变化的色原体的弹性制品。 例如，在一个实施方案中，色原是在细菌或其它微生物存在下经历颜色变化的溶剂化色素染料（例如，Reichardt's染料）。 更具体地，这样的染料可以响应微生物组分（例如细胞膜，细胞质等）与细胞外的环境之间的极性差异。 或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。

公开(公告)号：US07258878B2

公开(公告)日：2007-08-21

申请号：US11017226

申请日：2004-12-20

申请人： Sharon Linda Greene ,  Yanbin Huang ,  Lei Huang ,  Ilona F. Weart ,  Shu-Ping Yang ,  Sohail Malik ,  Robert B. Johnson

发明人： Sharon Linda Greene ,  Yanbin Huang ,  Lei Huang ,  Ilona F. Weart ,  Shu-Ping Yang ,  Sohail Malik ,  Robert B. Johnson

IPC分类号： A61K36/752

CPC分类号： A61K45/06 ,  A61K31/19 ,  A61K31/215 ,  A61K31/7048 ,  A61K36/61 ,  A61K2300/00

摘要： The present invention is directed to anti-microbial compositions and methods for treating fungal and yeast infections.

摘要翻译： 本发明涉及用于治疗真菌和酵母菌感染的抗微生物组合物和方法。

公开(公告)号：US5146297A

公开(公告)日：1992-09-08

申请号：US783432

申请日：1991-10-25

申请人： Steven R. Collins ,  Robert B. Johnson

发明人： Steven R. Collins ,  Robert B. Johnson

IPC分类号： H01L27/08 ,  H01L29/06 ,  H01L29/861

CPC分类号： H01L27/0814 ,  H01L29/0692 ,  H01L29/861

摘要： A precision voltage reference device having a forward biased and reverse biased silicon junctions arranged as a concentric circular annular monolithic structure is described. Selective hardening of the forward biased junction is provided to adjust carrier lifetime in said junction thereby providing a radiation hardened device. The selective hardening is provided by implanting non-dopant species to induce a predetermined amount of lattice damage at the forward biased junction. This arrangement permits both the forward biased junction and the reverse biased junction to be fabricated on a common substrate.

摘要翻译： 描述了具有布置为同心圆形环形整体结构的正向偏置和反向偏置硅结的精密电压参考装置。 提供正向偏置结的选择性硬化以调节所述结中的载流子寿命，从而提供辐射硬化装置。 选择性硬化是通过注入非掺杂剂物质以在正向偏置结处引起预定量的晶格损伤来提供的。 这种布置允许正向偏置结和反向偏置结两者制造在公共衬底上。

公开(公告)号：US4795413A

公开(公告)日：1989-01-03

申请号：US44005

申请日：1987-04-29

申请人： Robert B. Johnson ,  Robert P. Smith

发明人： Robert B. Johnson ,  Robert P. Smith

IPC分类号： B31B7/00 ,  B65B43/30 ,  B31B1/78 ,  B31B7/80

CPC分类号： B65B43/30 ,  B31B2217/0053 ,  Y10T156/1906 ,  Y10T29/53683

摘要： The invention provides an apparatus and method for automatically opening a plastic bag-type liner as part of a container lining process. The apparatus comprises at least one movable jaw assembly disposed on each side of the liner to be opened and a tongue on the other side of the liner opposing each jaw assembly. To open the bag, the jaws are opened and the jaw assemblies are moved toward and contact the liner and the opposing tongue pushes the liner between the gripping surfaces of the jaws of the opposing jaw assembly; as the jaw assemblies begin to move apart, the jaws close, gripping and retaining the layer of liner in direct contact with the gripping surfaces of each jaw, the tongues slide out from between the layers of the liner, separating the sides of the unsealed end of the liner. A stream of air may then be directed into the open end of the bag for completely blowing the bag open prior to placing the bag over the open end of the container to be lined and forcing the liner into the container.

摘要翻译： 本发明提供一种自动打开塑料袋式衬套作为容器衬里工艺的一部分的装置和方法。 该装置包括设置在待打开的衬垫的每一侧上的至少一个活动夹爪组件和位于衬套的另一侧上的与每个夹爪组件相对的舌头。 为了打开袋子，夹爪被打开并且钳口组件移动并接触衬套，并且相对的舌片将衬垫推到相对的钳口组件的钳口的夹持表面之间; 当钳口组件开始分离时，钳口关闭，夹持并保持衬垫层与每个钳口的抓握表面直接接触，舌片从衬垫层之间滑出，分离未密封端的侧面 的班轮。 然后可以将空气流引导到袋的开口端中，以在将袋放置在待衬里的容器的开口端上并迫使衬垫进入容器之前完全吹动袋打开。

公开(公告)号：US4451880A

公开(公告)日：1984-05-29

申请号：US202821

申请日：1980-10-31

申请人： Robert B. Johnson ,  Chester M. Nibby, Jr.

发明人： Robert B. Johnson ,  Chester M. Nibby, Jr.

IPC分类号： G06F12/00 ,  G06F12/06 ,  G06F13/16 ,  G06F13/28 ,  H04L25/49 ,  G06F13/00

CPC分类号： G06F13/1642 ,  G06F13/28

摘要： A memory controller controls the operation of a number of memory module units and includes a number of queues which couple to the module units. Each queue includes an address queue register, a control queue register and a data queue register. Each address queue register has tristate control for independent operation. Control circuits which couple to the queue address, control and data registers assign memory cycles between queues on an alternate basis when the queue control registers store requests which are being processed. This enables the interleaving of memory requests which eliminates processing delays particularly in cases where such requests involve multiword transfers over successive memory cycles of operation.

摘要翻译： 存储器控制器控制多个存储器模块单元的操作，并且包括耦合到模块单元的多个队列。 每个队列包括地址队列寄存器，控制队列寄存器和数据队列寄存器。 每个地址队列寄存器都有三态控制，用于独立操作。 当队列控制寄存器存储正在处理的请求时，耦合到队列地址，控制和数据寄存器的控制电路在备用的队列之间分配存储器周期。 这使得能够消除处理延迟的存储器请求的交织，特别是在这种请求涉及在连续存储器操作周期中的多字传输的情况下。

公开(公告)号：US4376972A

公开(公告)日：1983-03-15

申请号：US110521

申请日：1980-01-08

申请人： Robert B. Johnson ,  Chester M. Nibby, Jr. ,  Dana W. Moore

发明人： Robert B. Johnson ,  Chester M. Nibby, Jr. ,  Dana W. Moore

IPC分类号： G11C11/401 ,  G06F12/02 ,  G06F12/04 ,  G06F12/06 ,  G06F13/12 ,  G06F13/00

CPC分类号： G06F12/04 ,  G06F12/02

摘要： A memory subsystem which couples to a multiword bus for processing memory requests received therefrom includes at least a pair of independently addressable dynamic memory module units. Each memory unit includes a number of rows of random access memory (RAM) chips. The subsystem further includes an adder circuit, a pair of tri-state operated address register circuits and timing circuits. The address circuits include a pair of tri-state operated address registers which couple to the bus and to the set of address lines to each memory unit. In response to a memory request, the registers store row and column address portions of a chip address of the memory request. A multibit adder circuit is connected to increment by one the low order row address when the least significant address bits of the memory request indicate a subboundary address condition thereby enabling access to a pair of sequential word locations. Whenever a memory request specifies an address which cannot access a double word, boundary circuits upon detecting the condition cause the timing circuits to generate only timing signals necessary for accessing the first word location.

摘要翻译： 耦合到多字总线以用于处理从其接收的存储器请求的存储器子系统包括至少一对独立可寻址的动态存储器模块单元。 每个存储器单元包括多行随机存取存储器（RAM）芯片。 子系统还包括加法器电路，一对三态操作地址寄存器电路和定时电路。 地址电路包括一对三态操作地址寄存器，其耦合到总线和到每个存储器单元的地址线集合。 响应于存储器请求，寄存器存储存储器请求的芯片地址的行和列地址部分。 当存储器请求的最低有效地址位指示子边界地址条件从而使得能够访问一对顺序字位置时，多位加法器电路被连接以递增一个低位行地址。 每当存储器请求指定不能访问双字的地址时，边界电路在检测到条件时，使定时电路仅产生访问第一字位置所必需的定时信号。

公开(公告)号：US07619008B2

公开(公告)日：2009-11-17

申请号：US11194039

申请日：2005-07-29

申请人： Shu-Ping Yang ,  Lei Huang ,  Stephanie M. Martin ,  Julie Villanueva ,  Sharon Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert B. Johnson

发明人： Shu-Ping Yang ,  Lei Huang ,  Stephanie M. Martin ,  Julie Villanueva ,  Sharon Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert B. Johnson

IPC分类号： A61K31/045

CPC分类号： A61K31/7004 ,  A61K9/0034 ,  A61K31/047

摘要： A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.

摘要翻译： 提供了使用治疗剂抑制和/或治疗阴道感染的阴道治疗组合物。 治疗剂能够抑制和/或杀死加德纳（Gardnerella vaginalis），念珠菌（例如白色念珠菌）和/或滴虫（例如阴道毛滴虫）病原体。 理想地，实现了这样的抗微生物效能，而基本上不抑制嗜酸乳杆菌的生长。 例如，本发明中可以使用糖和/或糖醇作为抑制和/或治疗阴道感染的治疗剂。 在一个具体实施方案中，D-木糖醇用作治疗剂。

公开(公告)号：US4558429A

公开(公告)日：1985-12-10

申请号：US331933

申请日：1981-12-17

申请人： George J. Barlow ,  Chester M. Nibby, Jr. ,  Robert B. Johnson

发明人： George J. Barlow ,  Chester M. Nibby, Jr. ,  Robert B. Johnson

IPC分类号： G06F13/16 ,  G06F12/00 ,  G06F13/18 ,  G06F13/28 ,  G06F13/32 ,  G06F9/00

CPC分类号： G06F13/18 ,  G06F13/28

摘要： A data processing system includes a plurality of memory command generating units which connect to a common bus network with a number of memory subsystems. Each subsystem includes a controller which controls the operation of a number of memory module units and includes a number of queue circuits for storing memory requests to be processed. The memory controller further includes control apparatus connected to monitor bus activity. In response to certain bus activity conditions occurring during multiword transfer operations, the control apparatus operates to lengthen the time between successive multiword transfers of data to the bus so as to ensure that new requestors having lower priorities than a memory controller gain access to an available queue notwithstanding the amount of bus delay incurred in transmitting their memory requests.

摘要翻译： 数据处理系统包括多个存储器命令生成单元，其连接到具有多个存储器子系统的公共总线网络。 每个子系统包括控制多个存储器模块单元的操作的控制器，并且包括用于存储要处理的存储器请求的多个队列电路。 存储器控制器还包括连接到监视总线活动的控制装置。 响应于在多字传输操作期间发生的某些总线活动条件，控制装置操作以将数据的连续多字传输之间的时间延长到总线，以便确保具有比存储器控制器低的优先级的新请求者获得对可用队列的访问 尽管在发送其内存请求时发生总线延迟的数量。

公开(公告)号：US4507730A

公开(公告)日：1985-03-26

申请号：US413631

申请日：1982-09-03

申请人： Robert B. Johnson ,  Chester M. Nibby, Jr. ,  Edward R. Salas

发明人： Robert B. Johnson ,  Chester M. Nibby, Jr. ,  Edward R. Salas

IPC分类号： G06F11/00 ,  G06F12/06 ,  G11C29/00 ,  G06F13/00

CPC分类号： G11C29/76 ,  G06F11/006 ,  G06F12/0661

摘要： A memory system includes a plurality of memory controllers which connect to a common bus. Each memory controller includes reconfiguration apparatus which enables the controller when faulty to be switched off line and another controller to be substituted in its place so as to maintain system memory contiguous.

摘要翻译： 存储器系统包括连接到公共总线的多个存储器控制器。 每个存储器控制器包括重新配置装置，其使控制器在故障切断时能够使控制器在其位置被替换，从而使系统存储器连续。