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    XENOTRANSPLANT FOR CNS THERAPY
    7.
    发明申请
    XENOTRANSPLANT FOR CNS THERAPY 审中-公开
    XENOTRANSPLANT FOR CNS治疗

    公开(公告)号：US20090181064A1

    公开(公告)日：2009-07-16

    申请号：US12398642

    申请日：2009-03-05

    申请人： Robert Bartlett Elliott ,  Stephen John Martin Skinner ,  Christopher Edward Williams

    发明人： Robert Bartlett Elliott ,  Stephen John Martin Skinner ,  Christopher Edward Williams

    IPC分类号： A61K35/12 ,  A61F2/02 ,  A61P25/00 ,  A61P25/28

    CPC分类号： A61L27/3821 ,  A61K35/12 ,  A61K35/30 ,  A61K2035/128 ,  A61L27/3813 ,  A61L27/383 ,  A61L27/3878 ,  C12N5/0618 ,  C12N5/069

    摘要： A “supplementary choroid plexus” comprising preferably a xenotransplant of choroid plexus cells from a neonatal mammal provides a steady supply of trophic factors for administration to a central nervous system in need of treatment for a neurological disease. Choroid plexus cells manufacture a range of trophic factors, particularly during fetal development. This neurotrophic factor therapy may be useful in treating clinical and subclinical neurodegenerative diseases particularly those in which the choroid plexus has often become atrophic. The xenotransplant is cloaked in a protective layer (such as of alginate) capable of concealing the foreign nature of the transplant. Lateral ventricles are the preferred implantation site, from where the trophic factors are carried through the neuropil by the circulation of cerebrospinal fluid.

    摘要翻译： 优选地包含来自新生儿哺乳动物的脉络丛神经细胞的异种移植物的“补充性脉络丛”为营养因子提供了稳定的供给给需要治疗神经疾病的中枢神经系统的营养因子。 脉络丛细胞产生一系列营养因子，特别是在胎儿发育过程中。 这种神经营养因子治疗可用于治疗临床和亚临床神经变性疾病，特别是其中脉络丛经常萎缩的疾病。 异种移植物被掩盖在能够隐藏移植物的外来性质的保护层（例如藻酸盐）中。 侧脑室是优选的植入部位，营养因子由脑脊液循环通过神经纤维运送。

    NOVEL METHODS OF TREATMENT AND DELIVERY MODES
    8.
    发明申请
    NOVEL METHODS OF TREATMENT AND DELIVERY MODES 审中-公开
    新型治疗和输送方式

    公开(公告)号：US20080292611A1

    公开(公告)日：2008-11-27

    申请号：US12146895

    申请日：2008-06-26

    申请人： Robert Bartlett Elliott ,  Stephen John Martin Skinner

    发明人： Robert Bartlett Elliott ,  Stephen John Martin Skinner

    IPC分类号： A61K9/16 ,  A61K35/42 ,  A61K38/48 ,  A61P11/00

    CPC分类号： A61K9/5036 ,  A61K9/0019 ,  A61K9/5073 ,  A61K35/42 ,  A61K38/4886 ,  A61K48/0075 ,  C12Y304/24017 ,  A61K2300/00

    摘要： The invention relates to a novel method of administration, and device employed in the method, for administering a treatment species to the lungs of a recipient patient. The method involves introducing the device of the invention to the venous system of the patient, the size of the treatment species being such that, upon introduction to the venous system of the patient, the device will impact in a region of a lung capillary of the patient. The treatment species gains access to the lung and/or lung epithelia due to proteases associated with the treatments species. The application of the method to the treatment of cystic fibrosis is also claimed.

    摘要翻译： 本发明涉及一种新的给药方法和该方法中使用的装置，用于将受治疗物种给予接受者患者的肺。 该方法包括将本发明的装置引入到患者的静脉系统中，治疗种类的大小使得在引入患者的静脉系统时，该装置将影响患者的肺毛细血管区域 患者。 由于与处理物种相关的蛋白酶，处理物种获得进入肺和/或肺上皮细胞的能力。 还要求使用该方法治疗囊性纤维化。

    PREPARATION AND XENOTRANSPLANTATION OF PORCINE ISLETS
    9.
    发明申请
    PREPARATION AND XENOTRANSPLANTATION OF PORCINE ISLETS 有权
    磷离子的制备和XENOTRANSPLANS

    公开(公告)号：US20080279827A1

    公开(公告)日：2008-11-13

    申请号：US11932538

    申请日：2007-10-31

    申请人： Robert Bartlett Elliott ,  Riccardo Calafiore ,  Gusseppe Basta

    发明人： Robert Bartlett Elliott ,  Riccardo Calafiore ,  Gusseppe Basta

    IPC分类号： A61K36/00 ,  C12N5/00 ,  A61P3/10 ,  C12N5/02

    CPC分类号： C12N5/0677 ,  A61K35/12 ,  A61K2035/128 ,  C12N2500/38 ,  C12N2501/998 ,  C12N2501/999 ,  C12N2509/00

    摘要： The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xenotransplantation of producing porcine insulin in an appropriate recipient mammal, the method including or comprising the steps of: (I) harvesting the pancreas of piglets at or near full term gestation, and (ii) extracting pancreatic β islet cells from the harvested pancreas wherein the islets (at least at some stage in the performance of the method) are exposed to nicotinamide. Further, the invention relates to a method of encapsulation of a xenotransplantable porcine islet preparation, and transplantation of such a preparation, or a capsule containing such a preparation, into an appropriate recipient mammal.

    摘要翻译： 本发明涉及哺乳动物糖尿病治疗的发展。 特别地涉及一种制备能够在合适的受体哺乳动物中异种移植产生猪胰岛素的异种移植的猪胰岛制剂的方法，所述方法包括或包括以下步骤：（I）在全期妊娠或接近全期妊娠收获仔猪的胰腺， 和（ii）从收获的胰腺中提取胰岛β岛细胞，其中胰岛（至少在该方法的某一阶段）暴露于烟酰胺。 此外，本发明涉及一种非异种移植的猪胰岛制剂的包封方法，以及将这种制剂或含有这种制剂的胶囊移植到合适的受体哺乳动物中。