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公开(公告)号：US20120077781A1
公开(公告)日：2012-03-29
申请号：US12737781
申请日：2009-08-11
申请人： Robert Gadwood , Harpreet Kaur , Kevin Kells , Jeffrey A. Leiby , David Moon , Vinh Pham , Philip D.G. Coish , Kenneth F. Blount , Brian R. Dixon , Jayhyuk Myung , David Osterman , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Bruce R. Evans , Tan Quach , Heinrich J. Schostarez , Frank C. Sciavolino , Dennis Underwood , Phil Wickens , Jeffrey Wilson , Justin Wu
发明人： Robert Gadwood , Harpreet Kaur , Kevin Kells , Jeffrey A. Leiby , David Moon , Vinh Pham , Philip D.G. Coish , Kenneth F. Blount , Brian R. Dixon , Jayhyuk Myung , David Osterman , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Bruce R. Evans , Tan Quach , Heinrich J. Schostarez , Frank C. Sciavolino , Dennis Underwood , Phil Wickens , Jeffrey Wilson , Justin Wu
IPC分类号： A61K31/675 , A61P31/04 , C07D487/04 , C07F9/6561 , A61K31/525 , A61K31/5377
CPC分类号： A61K31/495 , A61K31/505 , C07D475/02 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/481
摘要： The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.
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公开(公告)号：US20120295903A1
公开(公告)日：2012-11-22
申请号：US13381809
申请日：2010-06-30
申请人： Kenneth F. Blount , Philip D.G. Coish , Brian R. Dixon , Jayhyuk Myung , David Osterman , Phil Wickens , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Harpreet Kaur , David Moon , Vinh Pham , Andrew Roughton , Jeffrey Wilson , Jeffrey A. Leiby , Dennis Underwood , Paul Adrian Aristoff , Heinrich J. Schostarez , Robert A. Chrusciel , Thomas R. Belliotti , Bruce R. Evans , Frank C. Sciavolino , Manuel A. Navia
发明人： Kenneth F. Blount , Philip D.G. Coish , Brian R. Dixon , Jayhyuk Myung , David Osterman , Phil Wickens , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Harpreet Kaur , David Moon , Vinh Pham , Andrew Roughton , Jeffrey Wilson , Jeffrey A. Leiby , Dennis Underwood , Paul Adrian Aristoff , Heinrich J. Schostarez , Robert A. Chrusciel , Thomas R. Belliotti , Bruce R. Evans , Frank C. Sciavolino , Manuel A. Navia
IPC分类号： C07D487/04 , A01P1/00 , A61K31/5377 , A61P31/04 , A61K31/525 , A01N43/90
CPC分类号： C07D487/04
摘要： The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.
摘要翻译： 本发明涉及新的黄素衍生物和其它黄素衍生物，其用途和用作核糖开关配体和/或抗感染剂的组合物。 本发明还提供了制备新型黄素衍生物的方法。
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公开(公告)号：US20130029980A1
公开(公告)日：2013-01-31
申请号：US13640054
申请日：2011-04-06
申请人： Philip D. G. Coish , Brian R. Dixon , David Osterman , Paul Adrian Aristoff , Manuel Navia , Frank Sciavolino , Stephanie Avola , Nick Baboulas , Thomas R. Belliotti , Angelica Bello , Judd Berman , Robert A. Chrusciel , Bruce R. Evans , Harpreet Kaur , David Moon , Vinh Pham , Andrew Roughton , Phil Wickens , Jeffrey Wilson , Heinrich J. Schostarez
发明人： Philip D. G. Coish , Brian R. Dixon , David Osterman , Paul Adrian Aristoff , Manuel Navia , Frank Sciavolino , Stephanie Avola , Nick Baboulas , Thomas R. Belliotti , Angelica Bello , Judd Berman , Robert A. Chrusciel , Bruce R. Evans , Harpreet Kaur , David Moon , Vinh Pham , Andrew Roughton , Phil Wickens , Jeffrey Wilson , Heinrich J. Schostarez
IPC分类号： C07D487/04 , A61P31/04 , A61K31/5377 , A61K31/519 , C07D491/147
CPC分类号： A01N43/90 , C07D475/14
摘要： The present invention relates novel flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives.
摘要翻译： 本发明涉及新的黄素衍生物，其用途和用作核糖开关配体和/或抗感染剂的组合物。
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公开(公告)号：US20120283219A1
公开(公告)日：2012-11-08
申请号：US13257325
申请日：2010-03-25
申请人： Philip D.G. Coish , Phil Wickens , Brian R. Dixon , David Osterman , Uday R. Khire , Manuel Navia , Judd Berman , Harpreet Kaur , Jeffrey Wilson , Dennis Underwood
发明人： Philip D.G. Coish , Phil Wickens , Brian R. Dixon , David Osterman , Uday R. Khire , Manuel Navia , Judd Berman , Harpreet Kaur , Jeffrey Wilson , Dennis Underwood
IPC分类号： A61K31/519 , C07F9/6561 , C07D403/12 , C07F9/6512 , A61P1/12 , A61P31/00 , A61P31/04 , A61P31/10 , A61P13/02 , C07D475/08 , A61K31/675
CPC分类号： C07D475/08
摘要： The present invention relates novel diaminopteridine derivatives, their compositions and method of treatment comprising the same for use as anti-infectives.
摘要翻译： 本发明涉及新型的二氨基脒衍生物，其组合物和包含其的治疗方法用作抗感染剂。
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公开(公告)号：US20120135417A1
公开(公告)日：2012-05-31
申请号：US13375865
申请日：2010-06-02
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/16 , C12N2320/10
摘要： Methods, compositions and assays that measure the effect of a test compound on induction of ligand-induced ribowitch-mediated transcription termination are disclosed. The methods and the assays are useful in identifying drug candidates that modulate transcription by binding to a riboswitch, for example.
摘要翻译： 公开了测量化合物对诱导配体诱导的核糖核酸转录终止诱导作用的方法，组合物和测定方法。 方法和测定法可用于鉴定例如通过结合核糖开关调节转录的候选药物。
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公开(公告)号：US20050064531A1
公开(公告)日：2005-03-24
申请号：US10911242
申请日：2004-08-04
申请人： James Landro , David Osterman , Walter Pickett
发明人： James Landro , David Osterman , Walter Pickett
CPC分类号： C12Q1/25 , C12Q1/48 , G01N2500/00
摘要： The present invention relates to methods for assessing enzyme activity utilizing a phase partition system. In addition, the present invention also relates to methods for screening and identifying compounds that may be used, for example, for the treatment of diabetes, diabetes-related disorders, obesity, cardiovascular disease, cancer, and other diseases or disorders, using this phase partition system.
摘要翻译： 本发明涉及利用相分配系统评估酶活性的方法。 此外，本发明还涉及用于筛选和鉴定可用于例如用于治疗糖尿病，糖尿病相关疾病，肥胖症，心血管疾病，癌症和其它疾病或病症的化合物的方法，使用该相 分区系统
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公开(公告)号：US20060068456A1
公开(公告)日：2006-03-30
申请号：US11266030
申请日：2005-11-02
申请人： James Landro , David Osterman , Walter Pickett
发明人： James Landro , David Osterman , Walter Pickett
IPC分类号： C12Q1/48
CPC分类号： C12Q1/25 , C12Q1/48 , G01N2500/00
摘要： The present invention relates to methods for assessing enzyme activity utilizing a phase partition system. In addition, the present invention also relates to methods for screening and identifying compounds that may be used, for example, for the treatment of diabetes, diabetes-related disorders, obesity, cardiovascular disease, cancer, and other diseases or disorders, using this phase partition system.
摘要翻译： 本发明涉及利用相分配系统评估酶活性的方法。 此外，本发明还涉及用于筛选和鉴定可用于例如用于治疗糖尿病，糖尿病相关疾病，肥胖症，心血管疾病，癌症和其它疾病或病症的化合物的方法，使用该相 分区系统
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8.发明申请Device and methods for measuring the response of a least one cell to a medium 审中-公开用于测量至少一个细胞对培养基的响应的装置和方法公开(公告)号：US20050158845A1
公开(公告)日：2005-07-21
申请号：US10483461
申请日：2002-08-06
IPC分类号： C12M1/34 , C12Q1/00 , C12Q1/68 , C12Q1/70 , G01F1/64 , G01N15/10 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for measuring response of at least one cell to a medium, the response of at least one cell to a medium being characterized by a reaction time. In one embodiment of the present invention, the device includes a membrane and a side substrate defining a sample well in communication with the ambient air and for receiving the at least one cell such that the membrane is underneath the at least one cell. A sensor is positioned underneath the second surface of the membrane, and an inlet is in fluid communication with the sample well. A medium is introduced into the chamber through the inlet to form a droplet that surrounds the cell, and the sensor measures the response of the cell to the medium at a time period shorter than the reaction time.
摘要翻译： 用于测量至少一个细胞对培养基的响应的装置和方法，至少一个细胞对介质的响应的特征在于反应时间。 在本发明的一个实施例中，该装置包括膜和侧基板，其限定与环境空气连通的样品阱，并且用于接收至少一个电池，使得膜位于至少一个电池的下方。 传感器位于膜的第二表面下方，并且入口与样品阱流体连通。 通过入口将介质引入室中以形成围绕电池的液滴，并且传感器在比反应时间短的时间段测量电池对介质的响应。
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