摘要:
The present invention relates to compositions comprising polypeptides, especially polypeptides capable of specifically binding predetermined antigens. The polypeptide in the composition comprises at least two antigen binding sites. These at least two antigen binding sites are located on a single polypeptide chain. One of the at least two antigen binding sites specifically binds the human CD3 antigen. The polypeptide may exist in both monomeric form and multimeric form. The multimeric form of the polypeptide constitutes no more than 5% of the total weight of the combined monomeric and multimeric forms of said polypeptide.
摘要:
The present invention relates to compositions comprising polypeptides, especially polypeptides capable of specifically binding predetermined antigens. The polypeptide in the composition comprises at least two antigen binding sites. These at least two antigen binding sites are located on a single polypeptide chain. One of the at least two antigen binding sites specifically binds the human CD3 antigen. The polypeptide may exist in both monomeric form and multimeric form. The multimeric form of the polypeptide constitutes no more than 5% of the total weight of the combined monomeric and multimeric forms of said polypeptide.
摘要:
The present invention provides a pharmaceutical composition comprising a bispecific single chain antibody construct. Said bispecific single chain antibody construct is characterized to comprise or consist of at least two domains, whereby one of said at least two domains specifically binds to human EpCAM and comprises at least one CDR-H3 region comprising the amino acid sequence NXID antigen and a second domain binds to human CD3 antigen. The invention further provides a process for the production of the pharmaceutical composition of the invention, a method for the prevention, treatment or amelioration of a tumorous disease and the use of the disclosed bispecific single chain antibody construct and corresponding means in the prevention, treatment or amelioration of a tumorous disease.
摘要:
The invention proposes a friction coupling, in particular for use in motor vehicles, e.g. for controlling an air compressor, in which coupling at least two friction surfaces can be brought into frictional connection. According to the invention, two conical friction surface pairs are provided.
摘要:
A method of making a polysiloxane containing polymer is described. The method comprises the steps of the polycondensation of a) 100 parts by weight of oligomers comprising non-cyclic siloxane containing oligomers having at least two condensable groups per molecule alone or in a mixture with one or organic oligomers having at least two condensable groups per molecule in the presence of: b) at least 2 parts by weight per 100 parts of (a) of one or more condensation catalysts comprising a Bronsted acid or a Lewis acid c) at least 15 parts by weight per 100 parts of (a) of one or more liquefied gases or a supercritical fluid therefrom. Subsequent to the reaction completion the polysiloxane containing polymer is recovered by expansion of the liquefied gas(es) or supercritical fluid (c).
摘要:
A photovoltaic solar cell for converting incident electromagnetic radiation into electrical energy, including at least one base region of a base-doping type, designed in a silicon substrate; at least one emitter region of an emitter-doping type that is of an opposite doping type to the base-doping type; at least one metallic base-contacting structure connected, in an electrically conductive manner, to the base region, and at least one metallic emitter-contacting structure connected, in an electrically conductive manner, to the emitter region, the base region and emitter region being arranged in such a manner that a pn-junction is formed at least in some regions between said base and emitter regions. It is essential that the base-contacting structure overlaps the emitter region in a base-bypass region and that in said overlapping region, a diode-like semiconductor contact is designed between the base-contacting structure and the emitter region, said semiconductor contact being a metal semiconductor contact or as a metal-insulator-semiconductor contact, and/or that the emitter-contacting structure overlaps the base region in an emitter-bypass region and that in this overlapping region, a diode-like semiconductor contact is designed between the emitter-contacting structure and the base region, said semiconductor contact being a metal semiconductor contact or as a metal-insulator-semiconductor contact. The invention also relates to a method for producing a solar cell.
摘要:
The invention relates to a fastening element (1) for vehicle parts (5), in particular for fastening a heat shield to a bolt shaped fastening means (13) of a vehicle body, preferably an underbody of a motor vehicle, comprising a claw disk (2) and a spring washer (3), held at claws (2.1) of the claw disk, wherein the claw disk (2) comprises an opening (6) and the spring washer (3) can be interlocked with a bolt shaped fastening means (13), wherein the claw disk (2) comprises at least one clip element (8), associated with the opening (6) and oriented away from the spring washer (3), wherein the at least one clip element (8) is configured for insertion through an opening (7) in the vehicle part (5) or in the heat shield, and wherein the at least one clip element (8) comprises an undercut (10) for interlocking the rim portion of the opening (7) of the vehicle part (5) or of the heat shield.
摘要:
A method of making a polysiloxane containing polymer is described. The method comprises the steps of: i) Preparing a polysiloxane containing polymer by the polycondensation of siloxane containing monomers and/or oligomers which comprise at least 2 condensable groups per molecule, in the presence of (a) one or more condensation catalysts and optionally one or both of (b) a diluent (a plasticizer and/or extender) and/or an end-blocking agent; and ii) Where required quenching the polymerization process. The diluent, when present, is substantially retained within the resulting diluted polysiloxane containing polymer and the process takes place at a pressure of at least 75×105 Pa (0.75 MPa).
摘要:
A spring arrangement for a vehicle, in particular a rail vehicle, with a first spring device and a second spring device, wherein the first spring device and the second spring device are mechanically arranged in series, and are designed to support a component of the vehicle on a further component of the vehicle in a support direction, the first spring device has a first transverse rigidity in a transverse direction running transverse to the support direction, the second spring device has a second rigidity in the transverse direction which is smaller than the first transverse rigidity. The first spring device and the second spring device are arranged nested in the support direction.
摘要:
A hand power tool (10) with a housing (12) that accommodates a turnably driveable driven shaft (20) on which a machining, in particular disk-shaped, replaceably clampable tool is mounted, whereby the driven shaft (20) is capable of being stopped by means of an axially displaceable locking pin (36) that extends through a through hole of the housing (12) and is capable of being operated from the outside, said hand power tool being made more robust and more cost-effective to produce due to the fact that the diameter-length ratio of the through hole (35) and the locking pin (36) is less than 1.8 and, in particular, equal to 1.5.