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公开(公告)号:US07985745B2
公开(公告)日:2011-07-26
申请号:US11863925
申请日:2007-09-28
申请人: Marlon D. Cowart , Robert J. Altenbach , Huaqing Liu , Irene Drizin , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Kathryn J. Hancock, legal representative , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield
发明人: Marlon D. Cowart , Robert J. Altenbach , Huaqing Liu , Irene Drizin , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield
IPC分类号: A61K31/395 , A61K31/495 , A61K31/498 , A61K31/502 , A61P25/00 , A61P25/02 , A61P19/02
CPC分类号: A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
摘要: This invention discloses a method of treating pain by administering histamine H4 receptor ligands and compositions comprising the same.
摘要翻译: 本发明公开了一种通过施用组胺H 4受体配体和包含其的组合物来治疗疼痛的方法。
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公开(公告)号:US20080194538A1
公开(公告)日:2008-08-14
申请号:US11863925
申请日:2007-09-28
申请人: Marlon D. Cowart , Robert J. Altenbach , Huaqing Liu , Irene Drizin , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield , Kathryn J. Hancock
发明人: Marlon D. Cowart , Robert J. Altenbach , Huaqing Liu , Irene Drizin , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield , Kathryn J. Hancock
IPC分类号: A61K31/397 , A61K31/506 , A61P25/00 , A61P25/02 , A61P19/02
CPC分类号: A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
摘要: This invention discloses a method of treating pain by administering histamine H4 receptor ligands and compositions comprising the same.
摘要翻译: 本发明公开了一种通过施用组胺H 4受体配体和包含其的组合物来治疗疼痛的方法。
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公开(公告)号:US20080188452A1
公开(公告)日:2008-08-07
申请号:US11863559
申请日:2007-09-28
申请人: Robert J. Altenbach , Huaqing Liu , Irene Drizin , Marlon D. Cowart , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Kathryn J. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield
发明人: Robert J. Altenbach , Huaqing Liu , Irene Drizin , Marlon D. Cowart , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Kathryn J. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield
IPC分类号: A61K31/517 , C07D487/10 , C07D471/10 , A61K31/55 , C07D487/04 , C07D471/04 , C07D403/04 , C07D403/14 , A61P29/00 , A61P37/00 , A61P25/00 , A61P35/00
CPC分类号: C07H17/04 , C07D239/70 , C07D403/12 , C07D453/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D519/00
摘要: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
摘要翻译: 本文描述了大环苯并菲的嘧啶化合物,包含这些化合物的组合物,制备该化合物的方法,以及使用这些化合物和组合物治疗和预防疾病进展,病症和病症的方法。
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公开(公告)号:US08735411B2
公开(公告)日:2014-05-27
申请号:US11863559
申请日:2007-09-28
申请人: Robert J. Altenbach , Huaqing Liu , Irene Drizin , Marlon D. Cowart , Neil Wishart , David J. Babinski , Robert J. Gregg , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield , Kathryn J. Hancock
发明人: Robert J. Altenbach , Huaqing Liu , Irene Drizin , Marlon D. Cowart , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield
IPC分类号: A61K31/505 , C07D239/70
CPC分类号: C07H17/04 , C07D239/70 , C07D403/12 , C07D453/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D519/00
摘要: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
摘要翻译: 本文描述了大环苯并菲的嘧啶化合物,包含这些化合物的组合物,制备该化合物的方法,以及使用这些化合物和组合物治疗和预防疾病,病症和病症进展的方法。
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公开(公告)号:US20080092250A1
公开(公告)日:2008-04-17
申请号:US11546714
申请日:2006-10-12
IPC分类号: A01K67/027
CPC分类号: A01K67/027 , A01K2267/035
摘要: The present invention presents a novel activity-induced pain behavior in ostoeoarthritic animals, useful for pharmacological characterization of potential analgesics.
摘要翻译: 本发明提供在骨关节炎动物中的新的活性诱导的疼痛行为,其可用于潜在镇痛药的药理学表征。
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公开(公告)号:US08716450B2
公开(公告)日:2014-05-06
申请号:US12905474
申请日:2010-10-15
申请人: Tariq Ghayur , Rajesh V. Kamath , Junian Liu , Marie P. Honore
发明人: Tariq Ghayur , Rajesh V. Kamath , Junian Liu , Marie P. Honore
CPC分类号: C07K16/00 , C07K16/22 , C07K16/241 , C07K16/245 , C07K16/2866 , C07K16/44 , C07K16/46 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/73 , C07K2317/76
摘要: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译: 本发明涉及工程化的多价和多特异性结合蛋白,制备方法,具体涉及用于预防,诊断和/或治疗疾病的用途。
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公开(公告)号:US20110190314A1
公开(公告)日:2011-08-04
申请号:US13080071
申请日:2011-04-05
申请人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
发明人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
IPC分类号: A61K31/4439 , C07D413/04 , C07D413/14 , A61K31/444 , A61K31/497 , A61K31/496 , A61P25/00 , A61P25/28 , A61P25/32 , A61P25/30 , A61P25/18 , A61P9/10 , A61P29/00 , A61P31/00
CPC分类号: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译: 本发明涉及包含神经元烟碱性受体配体和α4和bgr2阳性变构调节剂,其使用方法和相关制品的组合物。
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公开(公告)号:US20110091463A1
公开(公告)日:2011-04-21
申请号:US12905474
申请日:2010-10-15
申请人: Tariq Ghayur , Rajesh V. Kamath , Junian Liu , Marie P. Honore
发明人: Tariq Ghayur , Rajesh V. Kamath , Junian Liu , Marie P. Honore
IPC分类号: C07K16/24 , C07K16/46 , C12N15/13 , C12N15/63 , C12N15/70 , C12N15/80 , C12N15/81 , C12N15/82 , C12N15/85 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12P21/08 , A61K39/395 , A61K51/10 , A61P19/02 , A61P37/00 , A61P3/10 , A61P9/10 , A61P9/00 , A61P13/12 , A61P25/16 , A61P7/06 , A61P11/00 , A61P17/06 , A61P19/08 , A61P15/00 , A61P5/00 , A61P35/00 , A61P35/02 , A61P31/12 , A61P1/04 , A61P31/18 , A61P31/00
CPC分类号: C07K16/00 , C07K16/22 , C07K16/241 , C07K16/245 , C07K16/2866 , C07K16/44 , C07K16/46 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/73 , C07K2317/76
摘要: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号:US20100210682A1
公开(公告)日:2010-08-19
申请号:US12709125
申请日:2010-02-19
申请人: Connie R. Faltynek , Arthur R. Gomtsyan , Marie P. Honore , Michael F. Jarvis , Shailen K. Joshi , Michael E. Kort , Philip R. Kym , Torben R. Neelands , Regina M. Reilly , Carol S. Surowy
发明人: Connie R. Faltynek , Arthur R. Gomtsyan , Marie P. Honore , Michael F. Jarvis , Shailen K. Joshi , Michael E. Kort , Philip R. Kym , Torben R. Neelands , Regina M. Reilly , Carol S. Surowy
IPC分类号: A61K31/4725 , A61K31/416 , A61K31/444 , A61K31/421 , A61P29/00
CPC分类号: A61K31/416 , A61K31/421 , A61K31/444 , A61K31/4725
摘要: Disclosed herein are methods for increasing analgesic potency of TRPV1 antagonists, said methods comprise of repeated administration of the TRPV1 antagonists in a subject. Methods for treating or preventing pain by repeated administration of a TRPV1 antagonist are also discussed.
摘要翻译: 本文公开了增加TRPV1拮抗剂的止痛效力的方法,所述方法包括在受试者中重复施用TRPV1拮抗剂。 还讨论了通过重复施用TRPV1拮抗剂治疗或预防疼痛的方法。
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公开(公告)号:US20080167286A1
公开(公告)日:2008-07-10
申请号:US11953625
申请日:2007-12-10
申请人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
发明人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
IPC分类号: A61K31/397 , A61K31/4439 , C07D413/04 , A61P25/00
CPC分类号: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译: 本发明涉及包含神经元烟碱性受体配体和α4β2阳性变构调节剂的组合物,其使用方法和相关制造方法。
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