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公开(公告)号:US07183270B2
公开(公告)日:2007-02-27
申请号:US10776828
申请日:2004-02-11
IPC分类号: A61K31/397 , A61K31/5383 , A61K31/496 , A61K31/454 , A61K61/4015 , C07D413/12 , C07D403/12 , C07D401/12 , C07D207/77 , C07D207/00 , C07D205/04
CPC分类号: C07D207/273 , C07D207/277 , C07D207/34 , C07D207/416 , C07D211/76 , C07D211/88 , C07D223/12 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D417/08 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要: The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma, processes for preparing and intermediates thereof.
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2.
公开(公告)号:US07338947B2
公开(公告)日:2008-03-04
申请号:US11545584
申请日:2006-10-10
IPC分类号: A61K31/397 , A61K31/5383 , A61K31/496 , A61K31/454 , A61K31/4015 , C07D413/12 , C07D403/12 , C07D401/12 , C07D207/00 , C07D205/04
CPC分类号: C07D207/273 , C07D207/277 , C07D207/34 , C07D207/416 , C07D211/76 , C07D211/88 , C07D223/12 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D417/08 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要: The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma, processes for preparing and intermediates thereof.
摘要翻译: 本申请描述了可用于预防类风湿性关节炎,多发性硬化,动脉粥样硬化和哮喘的式(I)的MCP-1或其药学上可接受的盐形式的调节剂,其制备方法及其中间体。
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3.
公开(公告)号:US20100204274A1
公开(公告)日:2010-08-12
申请号:US12670016
申请日:2008-07-23
申请人: Daniel S. Gardner , John V. Duncia , John Hynes , T.G. Murali Dhar , Percy H. Carter , Joseph B. Santella
发明人: Daniel S. Gardner , John V. Duncia , John Hynes , T.G. Murali Dhar , Percy H. Carter , Joseph B. Santella
IPC分类号: A61K31/4545 , C07D401/12 , A61K31/454 , C07D211/94 , A61K31/451 , C07D405/06 , C07D213/89 , A61P19/00 , A61P29/00 , A61P37/00
CPC分类号: C07D401/12 , C07D211/52 , C07D405/12
摘要: The present application describes modulators of MIP-1α of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, Q, T, W, Z, R1, R3, R4, R5, R5a and R5b, are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using the modulators of formula (I) are disclosed.
摘要翻译: 本申请描述了式(I)的MIP-1α或其立体异构体或前药或其药学上可接受的盐的调节剂,其中m,Q,T,W,Z,R 1,R 3,R 4,R 5,R 5a和R 5b如上定义 这里。 此外,公开了使用式(I)的调节剂治疗和预防炎性疾病如哮喘和过敏性疾病以及类风湿性关节炎和动脉粥样硬化的自身免疫病态的方法。
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4.
公开(公告)号:US20070208056A1
公开(公告)日:2007-09-06
申请号:US11625874
申请日:2007-01-23
申请人: Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
发明人: Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
IPC分类号: A61K31/454 , A61K31/445 , C07D211/22 , C07D401/02
CPC分类号: C07D211/52 , C07D211/18 , C07D211/38 , C07D211/58 , C07D211/70 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107
摘要: The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.
摘要翻译: 本申请描述了MIP-1α或CCR-1的取代的哌啶基调节剂或其立体异构体或其药学上可接受的盐。 此外,公开了使用所述调节剂治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫性病症如类风湿性关节炎和移植排斥的方法。
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5.
公开(公告)号:US20110245226A1
公开(公告)日:2011-10-06
申请号:US13155460
申请日:2011-06-08
申请人: Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
发明人: Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
IPC分类号: A61K31/451 , C07D295/192 , C07D417/12 , C07D409/12 , C07D405/12 , C07D401/12 , C07D403/12 , C07D417/14 , A61K31/454 , A61K31/4535 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/496 , A61K31/5377 , A61K31/4523 , A61P19/02 , A61P9/00 , A61P9/04 , A61P17/06 , A61P31/18 , A61P9/10 , A61P35/00 , A61P19/10
CPC分类号: C07D211/52 , C07D211/18 , C07D211/38 , C07D211/58 , C07D211/70 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107
摘要: The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.
摘要翻译: 本申请描述了MIP-1α或CCR-1的取代的哌啶基调节剂或其立体异构体或其药学上可接受的盐。 此外,公开了使用所述调节剂治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫性病症如类风湿性关节炎和移植排斥的方法。
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6.
公开(公告)号:US07601844B2
公开(公告)日:2009-10-13
申请号:US11625874
申请日:2007-01-23
申请人: Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
发明人: Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
IPC分类号: C07D211/60 , A61K31/445
CPC分类号: C07D211/52 , C07D211/18 , C07D211/38 , C07D211/58 , C07D211/70 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107
摘要: The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.
摘要翻译: 本申请描述了MIP-1α或CCR-1的取代的哌啶基调节剂或其立体异构体或其药学上可接受的盐。 此外,公开了使用所述调节剂治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫性病症如类风湿性关节炎和移植排斥的方法。
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7.
公开(公告)号:US07985861B2
公开(公告)日:2011-07-26
申请号:US12505724
申请日:2009-07-20
申请人: Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
发明人: Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
IPC分类号: C07D211/06 , A61K31/535
CPC分类号: C07D211/52 , C07D211/18 , C07D211/38 , C07D211/58 , C07D211/70 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107
摘要: The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.
摘要翻译: 本申请描述了MIP-1α或CCR-1的取代的哌啶基调节剂或其立体异构体或其药学上可接受的盐。 此外,公开了使用所述调节剂治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫性病症如类风湿性关节炎和移植排斥的方法。
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8.
公开(公告)号:US08501782B2
公开(公告)日:2013-08-06
申请号:US12670016
申请日:2008-07-23
申请人: Daniel S. Gardner , John V. Duncia , John Hynes , T.G. Murali Dhar , Percy H. Carter , Joseph B. Santella
发明人: Daniel S. Gardner , John V. Duncia , John Hynes , T.G. Murali Dhar , Percy H. Carter , Joseph B. Santella
IPC分类号: A61K31/4545 , A61K31/454 , A61K31/4525 , A61K31/451 , C07D405/12 , C07D401/12 , C07D401/04 , C07D211/52
CPC分类号: C07D401/12 , C07D211/52 , C07D405/12
摘要: The present application describes modulators of MIP-1α of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, Q, T, W, Z, R1, R3, R4, R5, R5a and R5b, are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using the modulators of formula (I) are disclosed.
摘要翻译: 本申请描述了式(I)的MIP-1α或其立体异构体或前药或其药学上可接受的盐的调节剂,其中m,Q,T,W,Z,R 1,R 3,R 4,R 5,R 5a和R 5b如上定义 这里。 此外,公开了使用式(I)的调节剂治疗和预防炎性疾病如哮喘和过敏性疾病以及类风湿性关节炎和动脉粥样硬化的自身免疫病态的方法。
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9.
公开(公告)号:US20090298833A1
公开(公告)日:2009-12-03
申请号:US12505724
申请日:2009-07-20
申请人: Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
发明人: Percy H. Carter , Cullen L. Cavallaro , John V. Duncia , Daniel S. Gardner , John Hynes , Rui-Qin Liu , Joseph B. Santella , Dharmpal S. Dodd
IPC分类号: A61K31/445 , C07D211/40 , C07D417/12 , C07D401/12 , C07D413/14 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P9/00 , A61P35/00 , A61P19/00 , A61P31/18
CPC分类号: C07D211/52 , C07D211/18 , C07D211/38 , C07D211/58 , C07D211/70 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107
摘要: The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.
摘要翻译: 本申请描述了MIP-1α或CCR-1的取代的哌啶基调节剂或其立体异构体或其药学上可接受的盐。 此外,公开了使用所述调节剂治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫性病症如类风湿性关节炎和移植排斥的方法。
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10.
公开(公告)号:US07829571B2
公开(公告)日:2010-11-09
申请号:US12354258
申请日:2009-01-15
申请人: Percy H. Carter , Robert J. Cherney , Douglas G. Batt , John V. Duncia , Daniel S. Gardner , Soo S. Ko , Anurag S. Srivastava , Michael G. Yang
发明人: Percy H. Carter , Robert J. Cherney , Douglas G. Batt , John V. Duncia , Daniel S. Gardner , Soo S. Ko , Anurag S. Srivastava , Michael G. Yang
IPC分类号: A61K31/519 , A61K31/4015 , C07D487/04 , C07D207/273
CPC分类号: C07D207/273 , C04B35/632 , C07D207/34 , C07D211/86 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要: The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
摘要翻译: 本申请描述了可用于治疗类风湿性关节炎,多发性硬化,动脉粥样硬化和哮喘的式(I)的MCP-1或其药学上可接受的盐形式的调节剂。
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