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公开(公告)号：US08349599B2
公开(公告)日：2013-01-08
申请号：US13228758
申请日：2011-09-09
摘要： Described are multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate. The complexes having a dehydrogenase subunit and a cytochrome C subunit. Also described are polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 描述了在碳底物的酶转化中起作用的多聚体氧化还原酶复合物。 具有脱氢酶亚基和细胞色素C亚基的复合物。 还描述了编码多聚体复合物的多核苷酸及其使用方法。
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公开(公告)号：US20110003353A1
公开(公告)日：2011-01-06
申请号：US12857480
申请日：2010-08-16
摘要： The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 本发明涉及在碳底物的酶促转化中起作用的多聚体氧化还原酶复合物，所述复合物具有脱氢酶亚基和细胞色素C亚基。 本发明还涉及编码多聚体复合物的多核苷酸及其使用方法。
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公开(公告)号：US20120064586A1
公开(公告)日：2012-03-15
申请号：US13228758
申请日：2011-09-09
摘要： The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 本发明涉及在碳底物的酶促转化中起作用的多聚体氧化还原酶复合物，所述复合物具有脱氢酶亚基和细胞色素C亚基。 本发明还涉及编码多聚体复合物的多核苷酸及其使用方法。
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公开(公告)号：US08034593B2
公开(公告)日：2011-10-11
申请号：US12857480
申请日：2010-08-16
摘要： The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 本发明涉及在碳底物的酶促转化中起作用的多聚体氧化还原酶复合物，所述复合物具有脱氢酶亚基和细胞色素C亚基。 本发明还涉及编码多聚体复合物的多核苷酸及其使用方法。
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公开(公告)号：US07803591B2
公开(公告)日：2010-09-28
申请号：US11872890
申请日：2007-10-16
摘要： Described are multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate. The complexes having a dehydrogenase subunit and a cytochrome C subunit. Also described are polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 描述了在碳底物的酶转化中起作用的多聚体氧化还原酶复合物。 具有脱氢酶亚基和细胞色素C亚基的复合物。 还描述了编码多聚体复合物的多核苷酸及其使用方法。
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公开(公告)号：US20080293124A1
公开(公告)日：2008-11-27
申请号：US11872890
申请日：2007-10-16
摘要： The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 本发明涉及在碳底物的酶促转化中起作用的多聚体氧化还原酶复合物，所述复合物具有脱氢酶亚基和细胞色素C亚基。 本发明还涉及编码多聚体复合物的多核苷酸及其使用方法。
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7.发明授权Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters 失效具有非功能性内源葡萄糖酸盐转运蛋白的代谢改造的细菌菌株公开(公告)号：US07419795B2
公开(公告)日：2008-09-02
申请号：US10842929
申请日：2004-05-10
IPC分类号： G01N33/53
摘要： The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
摘要翻译： 本发明涉及在细菌宿主细胞中工程代谢途径，其导致用于生产抗坏血酸（ASA）中间体的增强的碳流。 特别地，本发明涉及通过增加由内源性葡萄糖酸转运蛋白基因失活产生的葡萄糖酸盐的可利用性来增加细菌细胞中ASA中间体的产生。
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8.发明申请Metabolically Engineered Bacterial Strains Having Non-Functional Endogenous Gluconate Transporters 有权具有非功能性内源葡萄糖酸盐转运蛋白的代谢工程细菌菌株公开(公告)号：US20080299614A1
公开(公告)日：2008-12-04
申请号：US12141522
申请日：2008-06-18
摘要： The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
摘要翻译： 本发明涉及在细菌宿主细胞中工程代谢途径，其导致用于生产抗坏血酸（ASA）中间体的增强的碳流。 特别地，本发明涉及通过增加由内源性葡萄糖酸转运蛋白基因失活产生的葡萄糖酸盐的可利用性来增加细菌细胞中ASA中间体的产生。
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9.发明申请Metabolically Engineered Bacterial Strains Having Non-Functional Endogenous Gluconate Transporters 审中-公开具有非功能性内源葡萄糖酸盐转运蛋白的代谢工程细菌菌株公开(公告)号：US20120009635A1
公开(公告)日：2012-01-12
申请号：US13228833
申请日：2011-09-09
摘要： The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
摘要翻译： 本发明涉及在细菌宿主细胞中工程代谢途径，其导致用于生产抗坏血酸（ASA）中间体的增强的碳流。 特别地，本发明涉及通过增加由内源性葡萄糖酸转运蛋白基因失活产生的葡萄糖酸盐的可利用性来增加细菌细胞中ASA中间体的产生。
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10.发明授权Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters 有权具有非功能性内源葡萄糖酸盐转运蛋白的代谢改造的细菌菌株公开(公告)号：US08034583B2
公开(公告)日：2011-10-11
申请号：US12141522
申请日：2008-06-18
IPC分类号： C12P21/06
摘要： The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
摘要翻译： 本发明涉及在细菌宿主细胞中工程代谢途径，其导致用于生产抗坏血酸（ASA）中间体的增强的碳流。 特别地，本发明涉及通过增加由内源性葡萄糖酸转运蛋白基因失活产生的葡萄糖酸盐的可利用性来增加细菌细胞中ASA中间体的产生。
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