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公开(公告)号：US4814324A
公开(公告)日：1989-03-21
申请号：US23015
申请日：1987-03-06
申请人： Robert P. Borris , Richard W. Burg , Otto D. Hensens , Leeyuan Huang , Livia Kelemen , Sagrario Mochales
发明人： Robert P. Borris , Richard W. Burg , Otto D. Hensens , Leeyuan Huang , Livia Kelemen , Sagrario Mochales
CPC分类号： C07J71/0005 , Y10S435/911
摘要： The compounds of Formula I are produced by the aerobic fermentation of a fungus of the genus GLIOCLADIUM, ATCC No. 20826. ##STR1## The compounds of Formula I are inhibitors of testosterone 5.alpha.-reductase and are useful in the treatment and prevention of acne, seborrhea, female hirsutism and benign prostatic hypertrophy.
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公开(公告)号：US5132320A
公开(公告)日：1992-07-21
申请号：US496734
申请日：1990-03-21
申请人： James D. Bergstrom , Otto D. Hensens , Claude Dufresne , Leeyuan Huang , Janet C. Onishi , Deborah L. Zink
发明人： James D. Bergstrom , Otto D. Hensens , Claude Dufresne , Leeyuan Huang , Janet C. Onishi , Deborah L. Zink
IPC分类号： A01N43/90 , C07D491/08 , C12P17/18
CPC分类号： C07D491/08 , A01N43/90 , C12P17/181 , C12R1/645
摘要： This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
摘要翻译： 本发明涉及结构式（I）的化合物：（I）（CH2）4CHCH（CH2）4CHCHCH3，它们是角鲨烯合成酶抑制剂，因此可用作胆固醇降低剂。
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3.发明授权Bis-aryl ethers, compositions containing such compounds and methods of treatment 失效双芳基醚，含有这些化合物的组合物和处理方法
公开(公告)号：US5994412A
公开(公告)日：1999-11-30
申请号：US110006
申请日：1998-07-02
申请人： Seok H. Lee , Maria T. Diez , Fernando Pelaez , Marina Mojena Sanchez , M. Dolores Vilella Amils , Hans E. Huber , Denis R. Patrick , Otto D. Hensens , Rosalind G. Jenkins , Leeyuan Huang , Annie Z. Zhao , Deborah L. Zink , Anne Dombrowski , Gerald F. Bills
发明人： Seok H. Lee , Maria T. Diez , Fernando Pelaez , Marina Mojena Sanchez , M. Dolores Vilella Amils , Hans E. Huber , Denis R. Patrick , Otto D. Hensens , Rosalind G. Jenkins , Leeyuan Huang , Annie Z. Zhao , Deborah L. Zink , Anne Dombrowski , Gerald F. Bills
摘要： A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf.Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound.
摘要翻译： 公开了由式I表示的化合物：或其药学上可接受的盐或水合物。 该化合物对癌蛋白Raf具有抑制活性。 还包括药物组合物，治疗癌症的方法，产生真菌微生物的培养物和化合物发酵生产的方法。
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公开(公告)号：US5130445A
公开(公告)日：1992-07-14
申请号：US660201
申请日：1991-02-25
摘要： There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compounds structures are presented based upon analytical studies. The compounds have antifungal activity.
摘要翻译： 公开了从鉴定为MA-5000的微生物的发酵液中分离出的一系列大环内酯类，其形态学分析显示为吸水链霉菌菌株。 化合物结构基于分析研究提出。 该化合物具有抗真菌活性。
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公开(公告)号：US5096923A
公开(公告)日：1992-03-17
申请号：US496742
申请日：1990-03-21
申请人： James D. Bergstrom , Otto D. Hensens , Leeyuan Huang , Jerrold M. Liesch , Janet C. Onishi , Frank L. Vanmiddlesworth
发明人： James D. Bergstrom , Otto D. Hensens , Leeyuan Huang , Jerrold M. Liesch , Janet C. Onishi , Frank L. Vanmiddlesworth
IPC分类号： A01N43/90 , C07D493/08 , C12N9/10 , C12P9/00 , C12P17/18
CPC分类号： C07D493/08 , A01N43/90 , C12N9/1085 , C12P17/181 , C12P9/00 , C12R1/645
摘要： This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
摘要翻译： 本发明涉及结构式（I）的化合物：作为角鲨烯合成酶抑制剂，因此可用作胆固醇降低剂。
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公开(公告)号：US5028537A
公开(公告)日：1991-07-02
申请号：US202612
申请日：1988-06-06
CPC分类号： A01N57/12 , C07F9/117 , C07F9/6552 , C12P13/00 , C12P17/06 , C12R1/55 , Y10S435/898
摘要： There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compounds' structures are present based upon analytical studies. The compounds have antifungal activity.
摘要翻译： 公开了从鉴定为MA-5000的微生物的发酵液中分离出的一系列大环内酯类，其形态学分析显示为吸水链霉菌菌株。 基于分析研究，化合物的结构存在。 该化合物具有抗真菌活性。
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7.发明授权
公开(公告)号：US4871727A
公开(公告)日：1989-10-03
申请号：US135949
申请日：1987-12-21
申请人： Richard W. Burg , Eugene L. Dulaney , Otto D. Hensens , Jerrold M. Liesch , John G. Ondeyka , Carol F. Wichmann
发明人： Richard W. Burg , Eugene L. Dulaney , Otto D. Hensens , Jerrold M. Liesch , John G. Ondeyka , Carol F. Wichmann
IPC分类号： A61K31/575 , A61K31/58 , A61P11/08 , A61P17/00 , A61P25/04 , A61P29/00 , C07J5/00 , C07J9/00 , C07J17/00 , C07J31/00 , C12P33/00 , C12R1/77
CPC分类号： C07J31/006 , C07J5/00 , C12P33/00
摘要： There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of sail microorganism L-681,512 under controlled fermentation conditions.
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公开(公告)号：US5006466A
公开(公告)日：1991-04-09
申请号：US426836
申请日：1989-10-26
CPC分类号： C12R1/58 , C07K5/06139 , C12P17/188 , A61K38/00 , Y10S435/886 , Y10S435/902
摘要： Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.
摘要翻译： 维生素B1，具有下式的维他明霉素M1：具有式I-IV的维吉尼好霉素M1类似物：（I）图像（III） -IV是胆囊收缩素（CCK）和胃泌素的拮抗剂。 胆囊收缩素拮抗剂可用作止痛剂和用于治疗和预防动物，特别是人类的胃肠道，中枢神经和食欲调节系统的紊乱。 胃泌素拮抗剂可用于阻断人类胃泌素受体，并且可用作治疗溃疡，肿瘤或其它胃肠道疾病的药剂。 式I-IV的化合物是抗生素，并且可用作包括人在内的动物的抗微生物剂，并且可用作促进动物饲料利用的食品添加剂。 弗吉尼亚霉素M1和式I，III和IV的类似物是通过控制好氧发酵链霉菌链霉菌ATCC No.55327产生的，而式II的类似物是通过化学合成制备的。
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公开(公告)号：US4476139A
公开(公告)日：1984-10-09
申请号：US426585
申请日：1982-09-29
申请人： August J. Kempf , Kenneth E. Wilson , Otto D. Hensens , Richard L. Monaghan , Sheldon B. Zimmerman , Eugene L. Dulaney
发明人： August J. Kempf , Kenneth E. Wilson , Otto D. Hensens , Richard L. Monaghan , Sheldon B. Zimmerman , Eugene L. Dulaney
IPC分类号： A23K20/195 , C07H7/02 , C12P19/44 , A61K31/35 , C07D309/04
CPC分类号： C12R1/465 , A23K20/195 , C07H7/02 , C12P19/44
摘要： The antibiotic, L-681,217, having antibacterial and growth-permittant activity, is produced by fermentation of Streptomyces cattleya in a suitable nutrient media.
摘要翻译： 具有抗菌和生长 - 吸收活性的抗生素L-681,217通过在合适的营养培养基中发酵链霉菌（Streptomyces cattleya）产生。
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公开(公告)号：USRE36520E
公开(公告)日：2000-01-18
申请号：US188155
申请日：1998-11-04
申请人： Robert L. Smith , Wasyl Halczenko , George D. Hartman , Gerald E. Stokker , Edward S. Inamine , Otto D. Hensens , David R. Houck , Ta Jyh Lee
发明人： Robert L. Smith , Wasyl Halczenko , George D. Hartman , Gerald E. Stokker , Edward S. Inamine , Otto D. Hensens , David R. Houck , Ta Jyh Lee
IPC分类号： C07C69/732 , C07D309/30 , C12P7/62 , C12P17/06 , A61K31/225 , C07C69/74
CPC分类号： C07C69/732 , C07D309/30 , C12P17/06 , C12P7/62 , C12R1/365
摘要： Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formula (II): ##STR1##
摘要翻译： 新型3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂可用作抗高胆固醇血症药，并由以下通式（II）表示：
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