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公开(公告)号:US20060247448A1
公开(公告)日:2006-11-02
申请号:US10507067
申请日:2003-03-07
申请人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmanage , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John Wang , Satoshi Yamamoto , Naoki Yoneda
发明人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmanage , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: C07D313/08
CPC分类号: C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
摘要翻译: 本发明提供具有式(I)的化合物:另外提供其合成方法及其用于治疗各种疾病(包括炎性或自身免疫性疾病)以及涉及恶性肿瘤或增加血管发生的疾病的方法,其中R 1,R 11,X,Y,Z和n如本文所定义。
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公开(公告)号:US20130196987A1
公开(公告)日:2013-08-01
申请号:US13663857
申请日:2012-10-30
申请人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: C07D405/12 , C07D491/044 , C07D313/00
CPC分类号: C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要: The present invention provides compounds, methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis.
摘要翻译: 本发明提供了化合物,其合成方法及其用于治疗各种疾病(包括炎性或自身免疫性疾病)以及涉及恶性肿瘤或增加血管生成的疾病的方法。
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公开(公告)号:US07799827B2
公开(公告)日:2010-09-21
申请号:US10507067
申请日:2003-03-07
申请人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: A61K31/335 , C07D313/00
CPC分类号: C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
摘要翻译: 本发明提供了具有式(I)的化合物:另外提供了其合成方法及其用于治疗各种疾病(包括炎性或自身免疫性疾病以及涉及恶性肿瘤或增加血管发生的疾病)的方法,其中R1-R11, X,Y,Z和n如本文所定义。
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公开(公告)号:US08329742B2
公开(公告)日:2012-12-11
申请号:US12839873
申请日:2010-07-20
申请人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: A61K31/355 , C07D313/00
CPC分类号: C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译: 本发明提供了使用具有式(I)的化合物在治疗各种疾病(包括炎性或自身免疫性疾病)以及涉及恶性肿瘤或增加血管发生的疾病的方法,其中R1-R11,t,X,Y,Z和n 如本文所定义。
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公开(公告)号:US20110144101A1
公开(公告)日:2011-06-16
申请号:US12839873
申请日:2010-07-20
申请人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: A61K31/5377 , A61K31/335 , A61K31/4184 , A61P29/00 , A61P37/00 , A61P17/06 , A61P11/06 , A61P35/00 , A61P1/00
CPC分类号: C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译: 本发明提供了使用具有式(I)的化合物在治疗各种疾病(包括炎性或自身免疫性疾病)以及涉及恶性肿瘤或增加血管发生的疾病的方法,其中R1-R11,t,X,Y,Z和n 如本文所定义。
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公开(公告)号:US07915306B2
公开(公告)日:2011-03-29
申请号:US10657910
申请日:2003-09-09
申请人: Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda
发明人: Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: A61K31/335
CPC分类号: C07D493/04 , C07D313/00
摘要: The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein. In certain embodiments, the compositions are for systemic (e.g., oral) administration. In certain embodiments, methods for the treatment of various disorders including inflammatory or autoimmune disorders comprise systemically (e.g., orally) administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I).
摘要翻译: 本发明提供了包含具有式(I)的化合物的组合物:另外提供了其用于治疗各种疾病(包括炎性或自身免疫性疾病)以及涉及恶性肿瘤或增加血管发生的疾病的方法,其中R1-R11,X,Y, Z和n如本文所定义。 在某些实施方案中,组合物用于全身(例如口服)给药。 在某些实施方案中,用于治疗各种疾病(包括炎性或自身免疫性疾病)的方法包括全身(例如,口服)向有需要的受试者施用治疗有效量的式(I)化合物。
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7.
公开(公告)号:US08350059B2
公开(公告)日:2013-01-08
申请号:US12746672
申请日:2008-12-08
申请人: Roch Boivin , Silvio A. Campagna , Hong Du , Francis G. Fang , Thomas Horstmann , Charles-Andre Lemelin , Jing Li , Pamela McGuinness , Xiang Niu , Matthew J. Schnaderbeck , Kevin (kuo-ming) Wu , Xiaojie (jeff) Zhu
发明人: Roch Boivin , Silvio A. Campagna , Hong Du , Francis G. Fang , Thomas Horstmann , Charles-Andre Lemelin , Jing Li , Pamela McGuinness , Xiang Niu , Matthew J. Schnaderbeck , Kevin (kuo-ming) Wu , Xiaojie (jeff) Zhu
IPC分类号: C07D493/00
CPC分类号: C07D313/00 , C07D317/22 , C07D317/24 , C07D317/30 , C07D319/08 , C07D493/04 , Y02P20/55
摘要: Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) wherein R1-R12 are as defined herein.
摘要翻译: 本文公开了可用于制备大环内酯类的方法和中间体,例如其中R 1 -R 12如本文所定义的式(IV)化合物。
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8.INTERMEDIATES AND METHODS FOR MAKING ZEARALENONE MACROLIDE ANALOGS 有权
标题翻译: 制备ZEARALENONE MACROLIDE ANALOGS的中间体和方法公开(公告)号:US20110237805A1
公开(公告)日:2011-09-29
申请号:US12746672
申请日:2008-12-08
申请人: Roch Boivin , Silvio A. Campagna , Hong Du , Francis G. Fang , Thomas Horstmann , Charles-Andre Lemelin , Jing Li , Pamela Mcguinness , Xiang Niu , Matthew J. Schnaderbeck , Kevin (kuo-ming) Wu , Xiaojie (Jeff) Zhu
发明人: Roch Boivin , Silvio A. Campagna , Hong Du , Francis G. Fang , Thomas Horstmann , Charles-Andre Lemelin , Jing Li , Pamela Mcguinness , Xiang Niu , Matthew J. Schnaderbeck , Kevin (kuo-ming) Wu , Xiaojie (Jeff) Zhu
IPC分类号: C07D313/00
CPC分类号: C07D313/00 , C07D317/22 , C07D317/24 , C07D317/30 , C07D319/08 , C07D493/04 , Y02P20/55
摘要: Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) wherein R1-R12 are as defined herein.
摘要翻译: 本文公开了可用于制备大环内酯类的方法和中间体,例如其中R 1 -R 12如本文所定义的式(IV)化合物。
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公开(公告)号:US20130303489A1
公开(公告)日:2013-11-14
申请号:US13794635
申请日:2013-03-11
申请人: Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang
发明人: Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang
IPC分类号: A61K31/365 , A61K45/06 , A61K31/4178 , A61K31/496 , A61K31/422 , A61K31/5377 , A61K31/4025 , A61K31/4523 , A61K31/665
CPC分类号: A61K31/365 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4523 , A61K31/496 , A61K31/5377 , A61K31/665 , A61K45/06
摘要: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.
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公开(公告)号:US08609640B2
公开(公告)日:2013-12-17
申请号:US12180408
申请日:2008-07-25
申请人: Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang , Jiayi Wu
发明人: Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang , Jiayi Wu
IPC分类号: A01N57/00 , A61K31/665 , A01N43/02 , A61K31/335 , A01N43/76 , A61K31/42 , A61K31/415 , A61K31/497 , A61K31/535
CPC分类号: A61K31/365 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4523 , A61K31/496 , A61K31/5377 , A61K31/665 , A61K45/06
摘要: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.
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