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    METHOD FOR IMMUNOSENSING ON A LIPID LAYER USING MAGNETIC TUNNEL JUNCTIONS II
    1.
    发明公开
    METHOD FOR IMMUNOSENSING ON A LIPID LAYER USING MAGNETIC TUNNEL JUNCTIONS II 审中-公开

    公开(公告)号：US20240142441A1

    公开(公告)日：2024-05-02

    申请号：US18541708

    申请日：2023-12-15

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Regina Baranowski ,  Dieter Heindl ,  Nikolaus-Peter Stengele ,  Christian Wellner

    IPC: G01N33/543 ,  G01R33/09

    CPC classification number: G01N33/54306 ,  G01R33/098

    Abstract: The present invention concerns the field of diagnostics. In particular, it relates to a method for determining an analyte suspected to be present in a sample comprising contacting said sample with a sensor element comprising an anchor layer which is present on a solid support, a first binding agent which is capable of specifically binding to the analyte, which is anchored in the anchor layer, a second binding agent which is capable of specifically binding to the analyte when bound to the first binding agent and which is immobilized on the solid support, said second binding agent comprising at least one magnetic label, and a magnetic tunnel junction in functional proximity to the second binding agent which generates a signal elicited in proximity to the at least one magnetic label of the second binding agent, for a time and under conditions which allow for specific binding of the analyte suspected to be present in the sample to the first binding agent and specific binding of the second binding agent to the analyte bound to the first binding agent and detecting the formation the complex of first binding agent, analyte and second binding agent based on an altered signal which is generated by the magnetic tunnel junction whereby the analyte is determined. The present invention, further, relates to a device and a kit for determining an analyte suspected to be present in a sample and to the use of said device for determining an analyte suspected to be present in a sample.

    HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES
    5.
    发明申请
    HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES 有权

    公开(公告)号：US20210155976A1

    公开(公告)日：2021-05-27

    申请号：US17126439

    申请日：2020-12-18

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Frank Bergmann ,  Dieter Heindl ,  Michael Schraeml ,  Johannes Stoeckel

    IPC: C12Q1/6816

    Abstract: The present report relates to hybridizing single-stranded (ss-) oligonucleotides which entirely consist of locked nucleic acid (LNA) monomers. The present document shows hybridization experiments with pairs of entirely complementary ss-oligonucleotides which fail to form a duplex within a given time interval. The present report provides methods to identify such incompatible oligonucleotide pairs. In another aspect, the present report provides pairs of complementary ss-oligonucleotides which are capable of rapid duplex formation. The present report also provides methods to identify and select compatible oligonucleotide pairs. In yet another aspect the present report provides use of compatible oligonucleotide pairs as binding partners in binding assays, e.g. immunoassays.

    BINDING AGENT
    7.
    发明申请
    BINDING AGENT 审中-公开

    公开(公告)号：US20200277406A1

    公开(公告)日：2020-09-03

    申请号：US16821537

    申请日：2020-03-17

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

    IPC: C07K19/00 ,  C07K16/32 ,  C07K16/18 ,  C07K16/28

    Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

    Redoxindicators
    9.
    发明授权
    Redoxindicators 有权

    公开(公告)号：US10060907B2

    公开(公告)日：2018-08-28

    申请号：US15438859

    申请日：2015-08-21

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Peter Gebauer ,  Dieter Heindl ,  Carina Horn ,  Maksim Fomin

    IPC: G01N33/52 ,  G01N33/50 ,  C07D241/42 ,  C07D403/06

    CPC classification number: G01N33/52 ,  C07D241/40 ,  C07D241/42 ,  C07D401/06 ,  C07D403/06 ,  G01N33/5005

    Abstract: The present invention relates to a chemical compound or a salt or solvate thereof being a phenazine-, phenanthridine-, phenanthroline-, quinoline-, quinoxaline-, acridine-isoquinoline-, pyrazine- or pyridine-derivative comprising a conjugated π-system and a π-acceptor group, and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the chemical compound of the present invention. The present invention also relates to a method of determining the amount of an analyte in a test sample, comprising contacting said test sample with a chemical compound, with a chemistry matrix, or with a test element of the invention and estimating the amount of redox equivalents liberated or consumed by the chemical compound, by the chemical compound comprised in said chemistry matrix, or by the chemical compound comprised in said test element, in the presence of said test sample, thereby determining the amount of an analyte in said test sample. Moreover, the present invention relates to a system comprising a test element according to the present invention and a device comprising a sensor for measuring the amount of redox equivalents liberated or consumed.

    Phenazinium mediators
    10.
    发明授权
    Phenazinium mediators 有权

    公开(公告)号：US09988358B2

    公开(公告)日：2018-06-05

    申请号：US15290440

    申请日：2016-10-11

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Dieter Heindl ,  Christine Nortmeyer ,  Peter Gebauer ,  Stacy H. Duvall ,  Klaus Andreas Bauer-Espindola

    IPC: C07D241/46 ,  C12Q1/26

    CPC classification number: C07D241/46 ,  C12Q1/26

    Abstract: The present invention relates to a chemical compound or a salt or solvate thereof being an 1-amino-phenazine derivative and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the aforesaid chemical compound. Moreover, the present invention relates to a method for determining the amount of an analyte in a sample, comprising contacting said sample with a chemistry matrix according to the present invention, estimating the amount of electrons liberated or consumed by the chemistry matrix in the presence of said liquid sample, and thereby determining the amount of an analyte in a liquid sample.

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