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公开(公告)号：US20070009430A1
公开(公告)日：2007-01-11
申请号：US11361602
申请日：2006-02-24
申请人： Rodney Browitt , William Burch , Timothy Senden , Ross Stephens , David Shaw
发明人： Rodney Browitt , William Burch , Timothy Senden , Ross Stephens , David Shaw
CPC分类号： A61K51/1244 , A61K51/1206
摘要： A method for forming an inhalable isotope compound suitable for use in patient medical diagnosis, the method comprising the steps of: (a) electrolytic loading of a carbon crucible with the isotope; (b) sublimating any isotope carrier in the crucible; (c) ablating the isotope in a carbon crucible, forming an ablation aerosol; (d) directly delivering the aerosol for immediate use by a patient. The isotope can comprise technetium.
摘要翻译： 一种形成适用于患者医疗诊断的可吸入同位素化合物的方法，所述方法包括以下步骤：（a）碳同位素的碳坩埚的电解负载; （b）升华坩埚中的任何同位素载体; （c）在碳坩埚中烧蚀同位素，形成消融气溶胶; （d）直接输送气溶胶以供患者立即使用。 同位素可以包括锝。
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公开(公告)号：US20080171691A1
公开(公告)日：2008-07-17
申请号：US12010424
申请日：2008-01-24
申请人： Leif Roge Lund , Keld Dano , Ross Stephens , Nils Brunner , Helene Solberg , Claus Holst-Hansen , John Romer Nielsen
发明人： Leif Roge Lund , Keld Dano , Ross Stephens , Nils Brunner , Helene Solberg , Claus Holst-Hansen , John Romer Nielsen
IPC分类号： A61K38/17 , A61K31/192
CPC分类号： A61K31/404 , A61K31/40 , A61K38/57 , A61K45/06 , A61K2300/00
摘要： Invasive remodelling in a mammal may be inhibited by (1) inhibiting or abolishing the protein cleaving action of plasmin and (2) inhibiting or abolishing the protein cleaving action of at least one additional proteolytic enzyme active in invasive remodelling, such as a metalloprotease.
摘要翻译： 可通过（1）抑制或消除纤溶酶的蛋白质切割作用和（2）抑制或消除至少一种在侵袭性重塑中活化的另外的蛋白水解酶（例如金属蛋白酶）的蛋白质切割作用来抑制哺乳动物的侵袭性重塑。
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3.发明授权Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker 失效基质金属蛋白酶1型（TIMP-1）的组织抑制剂作为癌症标志物公开(公告)号：US07807379B2
公开(公告)日：2010-10-05
申请号：US11449869
申请日：2006-06-09
申请人： Mads Holten-Andersen , Ross Stephens , Hans Jørgen Nielsen , Ib Jarle Christensen , Nils Brünner
发明人： Mads Holten-Andersen , Ross Stephens , Hans Jørgen Nielsen , Ib Jarle Christensen , Nils Brünner
IPC分类号： G01N33/53
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57484 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.
摘要翻译： 本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否可能患有癌症的方法。
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4.发明申请Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker 失效基质金属蛋白酶1型（TIMP-1）的组织抑制剂作为癌症标志物公开(公告)号：US20070020707A1
公开(公告)日：2007-01-25
申请号：US11449869
申请日：2006-06-09
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57484 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is likely to have cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.
摘要翻译： 本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否可能患有癌症的方法。
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5.发明授权Peptide antagonists of the human urokinase receptor and method for selecting them 有权人尿激酶受体的肽拮抗剂及其选择方法公开(公告)号：US07026282B1
公开(公告)日：2006-04-11
申请号：US09743329
申请日：1999-07-01
申请人： Michael Ploug , Søren Østergaard , Claus Holst-Hansen , Ross Stephens , Keld Danø , Arne Holm
发明人： Michael Ploug , Søren Østergaard , Claus Holst-Hansen , Ross Stephens , Keld Danø , Arne Holm
CPC分类号： G01N33/5008 , A61K38/00 , C12N9/6462 , C12Y304/21073 , G01N33/5011 , G01N33/68 , G01N2500/00
摘要： A novel set of inhibitors of the binding interaction between human urokinase plasminogen activator (uPA) and its cell surface receptor (uPAR) has been developed. The inhibitors comprise of peptide fragments, monomeric or in multiple copies attached to a common scaffold, in which the amino acid sequence may include uncommon substituted amino acids to partially comprise of peptoid sequences. The present invention also relates to the use of such peptides in therapy, in particular for the treatment of cancer, having developed a modified non-human mammalian receptor to which the novel inhibitors are antagonistic.
摘要翻译： 已经开发了一组新的人类尿激酶纤溶酶原激活物（uPA）与其细胞表面受体（uPAR）之间的结合相互作用的抑制剂。 所述抑制剂包含连接于常见支架的单体或多拷贝的肽片段，其中氨基酸序列可以包括不常见的取代的氨基酸部分包含拟肽序列。 本发明还涉及这种肽在治疗中的用途，特别是用于治疗癌症，已开发了新的抑制剂对其拮抗的修饰的非人哺乳动物受体。
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公开(公告)号：US20050137121A1
公开(公告)日：2005-06-23
申请号：US10952160
申请日：2004-09-29
申请人： Leif Lund , Keld Dano , Ross Stephens , Nils Brunner , Helene Solberg , Claus Holst-Hansen , John Nielsen
发明人： Leif Lund , Keld Dano , Ross Stephens , Nils Brunner , Helene Solberg , Claus Holst-Hansen , John Nielsen
CPC分类号： A61K31/404 , A61K31/40 , A61K38/57 , A61K45/06 , A61K2300/00
摘要： Invasive remodelling in a mammal may be inhibited by (1) inhibiting or abolishing the protein cleaving action of plasmin and (2) inhibiting or abolishing the protein cleaving action of at least one additional proteolytic enzyme active in invasive remodelling, such as a metalloprotease.
摘要翻译： 可通过（1）抑制或消除纤溶酶的蛋白质切割作用和（2）抑制或消除至少一种在侵袭性重塑中活化的另外的蛋白水解酶（例如金属蛋白酶）的蛋白质切割作用来抑制哺乳动物的侵袭性重塑。
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