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公开(公告)号：US08101651B2
公开(公告)日：2012-01-24
申请号：US12258313
申请日：2008-10-24
IPC分类号： A61K31/381 , C07D333/80
CPC分类号： C07D307/93 , C07D307/91 , C07D333/80
摘要： Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.
摘要翻译： 本文公开的是本文公开的式I的化合物，调节雌激素受体的活性的方法和治疗与雌激素受体相关的病症的方法。
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公开(公告)号：US08822548B2
公开(公告)日：2014-09-02
申请号：US12915354
申请日：2010-10-29
申请人： Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson , Vladimir Sherbukhin , Birgitte Winther Lund
发明人： Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson , Vladimir Sherbukhin , Birgitte Winther Lund
IPC分类号： A61K31/055 , A61K31/05 , C07C37/055 , C07C37/62 , C07D263/32 , C07C39/42
CPC分类号： C07C37/055 , C07C17/263 , C07C17/2632 , C07C37/14 , C07C37/62 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/23 , C07C43/30 , C07C43/303 , C07C45/71 , C07C49/517 , C07C49/753 , C07C49/84 , C07C59/72 , C07C65/17 , C07C65/26 , C07C69/017 , C07C69/24 , C07C69/76 , C07C307/02 , C07C2601/14 , C07C2601/18 , C07C2602/20 , C07C2602/24 , C07D213/30 , C07D263/32 , C07D265/06 , C07D265/10 , C07D295/096 , C07D309/06 , C07D313/04 , C07D319/06 , C07D333/06 , C07D333/16 , C07F9/12 , C07C25/24 , C07C22/08 , C07C25/18
摘要： Disclosed herein are methods of treatment and prevention of diseases and disorders related to estrogen receptors comprising administering novel di-aromatic compounds to patients in need thereof.
摘要翻译： 本文公开了治疗和预防与雌激素受体相关的疾病和病症的方法，包括向有需要的患者施用新的二芳族化合物。
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公开(公告)号：US07825265B2
公开(公告)日：2010-11-02
申请号：US11269913
申请日：2005-11-08
申请人： Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson , Vladimir Sherbukhin , Birgitte Winther Lund
发明人： Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson , Vladimir Sherbukhin , Birgitte Winther Lund
IPC分类号： C07D309/00 , C07D321/00 , C07D405/00
CPC分类号： C07C37/055 , C07C17/263 , C07C17/2632 , C07C37/14 , C07C37/62 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/23 , C07C43/30 , C07C43/303 , C07C45/71 , C07C49/517 , C07C49/753 , C07C49/84 , C07C59/72 , C07C65/17 , C07C65/26 , C07C69/017 , C07C69/24 , C07C69/76 , C07C307/02 , C07C2601/14 , C07C2601/18 , C07C2602/20 , C07C2602/24 , C07D213/30 , C07D263/32 , C07D265/06 , C07D265/10 , C07D295/096 , C07D309/06 , C07D313/04 , C07D319/06 , C07D333/06 , C07D333/16 , C07F9/12 , C07C25/24 , C07C22/08 , C07C25/18
摘要： Disclosed herein are novel di-aromatic compounds and methods for using various di-aromatic compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
摘要翻译： 本文公开了新型二芳族化合物和使用各种二芳族化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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公开(公告)号：US20060122278A1
公开(公告)日：2006-06-08
申请号：US11269913
申请日：2005-11-08
申请人： Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson
发明人： Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson
IPC分类号： A61K31/192 , A61K31/13 , A61K31/045 , C07C39/12 , C07C50/04
CPC分类号： C07C37/055 , C07C17/263 , C07C17/2632 , C07C37/14 , C07C37/62 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/23 , C07C43/30 , C07C43/303 , C07C45/71 , C07C49/517 , C07C49/753 , C07C49/84 , C07C59/72 , C07C65/17 , C07C65/26 , C07C69/017 , C07C69/24 , C07C69/76 , C07C307/02 , C07C2601/14 , C07C2601/18 , C07C2602/20 , C07C2602/24 , C07D213/30 , C07D263/32 , C07D265/06 , C07D265/10 , C07D295/096 , C07D309/06 , C07D313/04 , C07D319/06 , C07D333/06 , C07D333/16 , C07F9/12 , C07C25/24 , C07C22/08 , C07C25/18
摘要： Disclosed herein are novel di-aromatic compounds and methods for using various di-aromatic compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
摘要翻译： 本文公开了新的二芳族化合物和用于使用各种二芳族化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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公开(公告)号：US08470872B2
公开(公告)日：2013-06-25
申请号：US13325160
申请日：2011-12-14
IPC分类号： A61K31/381
CPC分类号： C07D307/93 , C07D307/91 , C07D333/80
摘要： Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.
摘要翻译： 本文公开的是本文公开的式I的化合物，调节雌激素受体的活性的方法和治疗与雌激素受体相关的病症的方法。
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公开(公告)号：US20090131510A1
公开(公告)日：2009-05-21
申请号：US12258313
申请日：2008-10-24
IPC分类号： A61K31/381 , C07D307/91 , C07D333/76 , A61P25/02 , A61K31/343
CPC分类号： C07D307/93 , C07D307/91 , C07D333/80
摘要： Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.
摘要翻译： 本文公开的是本文公开的式I的化合物，调节雌激素受体的活性的方法和治疗与雌激素受体相关的病症的方法。
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公开(公告)号：US20050256210A1
公开(公告)日：2005-11-17
申请号：US11120397
申请日：2005-05-03
申请人： Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson
发明人： Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson
IPC分类号： A61K31/05 , A61K31/055 , A61P5/30 , C07C17/26 , C07C37/14 , C07C39/00 , C07C39/12 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/23 , C07C43/30 , C07C49/753 , C07C59/72 , C07C65/26 , C07D309/12
CPC分类号： C07C43/23 , A61K31/05 , A61K31/055 , C07C17/263 , C07C17/2632 , C07C37/055 , C07C37/14 , C07C37/62 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/30 , C07C49/753 , C07C59/72 , C07C65/26 , C07C2601/14 , C07C2601/18 , C07D309/12 , C07C25/18
摘要： Disclosed herein are novel di-phenyl compounds and methods for using various di-phenyl compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
摘要翻译： 本文公开了新的二苯基化合物和使用各种二苯基化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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8.发明申请DIPHENYL SUBSTITUTED CYCLOHEXANE DERIVATIVES, USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS BETA 有权二氢替代环己烷衍生物，有用作为雌激素受体测定的调节剂公开(公告)号：US20140275284A1
公开(公告)日：2014-09-18
申请号：US14236237
申请日：2012-08-01
申请人： Roger Olsson , Birgitte Lund , Magnus Gustafsson
发明人： Roger Olsson , Birgitte Lund , Magnus Gustafsson
IPC分类号： C07C43/225 , C07C39/42
CPC分类号： C07C43/225 , C07C39/42 , C07C2601/14
摘要： Disclosed herein are novel di-aromatic compounds of the general formula (I). Also pharmaceutical compositions comprising the novel compounds and the use of the novel compounds in treatment and prevention of diseases and disorders related to estrogen receptors are disclosed. Furthermore, methods for treating and preventing diseases and disorders related to estrogen receptors by administration of the novel compounds are disclosed.
摘要翻译： 本文公开了通式（I）的新型二芳族化合物。 还公开了包含新化合物的药物组合物和新化合物在治疗和预防与雌激素受体相关的疾病和病症中的用途。 此外，公开了通过施用新化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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9.发明授权Diphenyl substituted cyclohexane derivatives, useful as modulators of the estrogen receptors beta 有权二苯基取代的环己烷衍生物，可用作雌激素受体β的调节剂公开(公告)号：US09061981B2
公开(公告)日：2015-06-23
申请号：US14236237
申请日：2012-08-01
申请人： Roger Olsson , Birgitte Lund , Magnus Gustafsson
发明人： Roger Olsson , Birgitte Lund , Magnus Gustafsson
IPC分类号： A61K31/075 , A61K31/045 , C07C43/02 , C07C43/225 , C07C39/42
CPC分类号： C07C43/225 , C07C39/42 , C07C2601/14
摘要： Disclosed herein are novel di-aromatic compounds of the general formula (I). Also pharmaceutical compositions comprising the novel compounds and the use of the novel compounds in treatment and prevention of diseases and disorders related to estrogen receptors are disclosed. Furthermore, methods for treating and preventing diseases and disorders related to estrogen receptors by administration of the novel compounds are disclosed.
摘要翻译： 本文公开了通式（I）的新型二芳族化合物。 还公开了包含新化合物的药物组合物和新化合物在治疗和预防与雌激素受体相关的疾病和病症中的用途。 此外，公开了通过施用新化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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公开(公告)号：US06812457B2
公开(公告)日：2004-11-02
申请号：US10621868
申请日：2003-07-17
IPC分类号： B01D2726
CPC分类号： B82Y30/00 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504
摘要： The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.
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