公开(公告)号：US5096810A

公开(公告)日：1992-03-17

申请号：US838588

申请日：1986-03-11

申请人： Roland Schwarting ,  Robert Evans

发明人： Roland Schwarting ,  Robert Evans

IPC分类号： C07K16/30

CPC分类号： C07K16/3061 ,  Y10S436/813 ,  Y10S530/808 ,  Y10S530/809

摘要： Monoclonal antibodies are described which are potent reagents for the immunologic definition of hairy leukemic cells.S-HCL 1 is a pan-B cell marker with markedly increased staining on hairy cells versus normal B-lymphocytes. It also stains with a variety of B-cell leukemias and lymphomas, but is not crossreactive with any other cell type in man. With these features, it is also a useful reagent for the detection of human B-lymphocytes.S-HCL-3 monoclonal antibody recognizes an antigen present on entirely different cell lineages, namely macrophages of almost all tissues and polymorphonuclear cells. This antigen is not expressed on any other malignant lymphocytes except hairy cells. Moreover, this antigen is not found on other non-Hodgkin lymphomas which may resemble hairy cell leukemia. Accordingly, b-HCl-3 is useful in the diagnosis of hairy cell leukemic.

摘要翻译： 描述了单克隆抗体是用于免疫定义毛状白血病细胞的有效试剂。 S-HCL 1是泛-B细胞标记，毛细胞染色显着高于正常B淋巴细胞。 它还用各种B细胞白血病和淋巴瘤染色，但与人类中的任何其他细胞类型没有交叉反应。 具有这些特征，它也是检测人类B淋巴细胞的有用试剂。 S-HCL-3单克隆抗体识别存在于完全不同细胞系的抗原，即几乎所有组织和多形核细胞的巨噬细胞。 除毛细胞外，该抗原不能在任何其他恶性淋巴细胞上表达。 此外，这种抗原在其他非霍奇金淋巴瘤上未发现，其可能类似于毛细胞白血病。 因此，b-HCl-3可用于诊断毛细胞白血病。