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公开(公告)号:US5981511A
公开(公告)日:1999-11-09
申请号:US813545
申请日:1997-03-05
申请人: Rolando E. Gapud , Timothy J. Hagen , Ann E. Hallinan , Donald W. Hansen, Jr. , Robert E. Manning , Suzanne Metz , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , R. Keith Webber
发明人: Rolando E. Gapud , Timothy J. Hagen , Ann E. Hallinan , Donald W. Hansen, Jr. , Robert E. Manning , Suzanne Metz , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , R. Keith Webber
IPC分类号: A61K31/00 , A61K31/155 , A61K31/195 , A61K31/197 , A61K31/22 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/42 , A61K31/535 , A61K31/5377 , A61K31/5395 , A61K31/55 , A61P9/00 , A61P25/04 , A61P29/00 , A61P37/00 , C07C257/14 , C07C259/14 , C07C271/22 , C07C275/16 , C07C313/28 , C07C313/34 , C07C323/60 , C07C327/22 , C07C329/02 , C07C329/06 , C07C333/04 , C07C391/00 , C07D223/12 , C07D233/54 , C07D233/56 , C07D233/76 , C07D261/08 , C07D273/02 , C07F7/08 , C07K5/068 , A01N55/00
CPC分类号: C07D233/64 , C07C257/14 , C07C259/14 , C07C275/16 , C07C313/28 , C07C323/60 , C07C327/22 , C07C329/02 , C07C329/06 , C07C333/04 , C07C391/00 , C07D223/12 , C07D261/08 , C07F7/0818
摘要: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
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公开(公告)号:US06344473B1
公开(公告)日:2002-02-05
申请号:US09633601
申请日:2000-08-07
申请人: Donald W. Hansen, Jr. , Arija A. Bergmanis , Timothy J. Hagen , E. Ann Hallinan , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , Mahima Trivedi , R. Keith Webber , Sofya Tsymbalov , Rolando E. Gapud
发明人: Donald W. Hansen, Jr. , Arija A. Bergmanis , Timothy J. Hagen , E. Ann Hallinan , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , Mahima Trivedi , R. Keith Webber , Sofya Tsymbalov , Rolando E. Gapud
IPC分类号: A61K314172
CPC分类号: C07D291/04 , C07D233/96 , C07D271/07 , C07D273/04 , C07D285/08
摘要: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
摘要翻译: 可用作一氧化氮合酶抑制剂的1,3-二唑啉和1,3-二唑烷基杂环衍生物。
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公开(公告)号:US6136829A
公开(公告)日:2000-10-24
申请号:US356735
申请日:1999-07-19
申请人: Donald W. Hansen, Jr. , Ariia A. Bergmanis , Timothy J. Hagen , E. Ann Hallinan , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , Mahima Trivedi , R. Keith Webber , Sofya Tsymbalov , Rolando E. Gapud
发明人: Donald W. Hansen, Jr. , Ariia A. Bergmanis , Timothy J. Hagen , E. Ann Hallinan , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , Mahima Trivedi , R. Keith Webber , Sofya Tsymbalov , Rolando E. Gapud
IPC分类号: A61K31/41 , A61K31/4166 , A61K31/4245 , A61K31/433 , A61K31/535 , A61K31/5377 , A61P9/02 , A61P43/00 , C07D233/96 , C07D271/06 , C07D271/07 , C07D273/04 , C07D285/08 , C07D291/04
CPC分类号: C07D291/04 , C07D233/96 , C07D271/07 , C07D273/04 , C07D285/08
摘要: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
摘要翻译: 可用作一氧化氮合酶抑制剂的1,3-二唑啉和1,3-二唑烷基杂环衍生物。
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4.1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors 失效
标题翻译: 1,3-二唑啉和1,3-二唑烷基杂环作为有用的一氧化氮合酶抑制剂公开(公告)号:US5981556A
公开(公告)日:1999-11-09
申请号:US898110
申请日:1997-07-22
申请人: Donald W. Hansen, Jr. , Arija A. Bergmanis , Timothy J. Hagen , E. Ann Hallinan , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , Mahima Trivedi , R. Keith Webber , Sofya Tsymbalov , Rolando E. Gapud
发明人: Donald W. Hansen, Jr. , Arija A. Bergmanis , Timothy J. Hagen , E. Ann Hallinan , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , Mahima Trivedi , R. Keith Webber , Sofya Tsymbalov , Rolando E. Gapud
IPC分类号: A61K31/41 , A61K31/4166 , A61K31/4245 , A61K31/433 , A61K31/535 , A61K31/5377 , A61P9/02 , A61P43/00 , C07D233/96 , C07D271/06 , C07D271/07 , C07D273/04 , C07D285/08 , C07D291/04 , C07D285/125 , C07D417/06
CPC分类号: C07D291/04 , C07D233/96 , C07D271/07 , C07D273/04 , C07D285/08
摘要: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
摘要翻译: 可用作一氧化氮合酶抑制剂的1,3-二唑啉和1,3-二唑烷基杂环衍生物。
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5.1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors 失效
标题翻译: 1,2,4-氧杂二氮杂双环和1,24-氧杂二氮杂环杂环作为有用的一氧化氮合酶抑制剂公开(公告)号:US5958958A
公开(公告)日:1999-09-28
申请号:US231478
申请日:1999-01-14
申请人: Donald W. Hansen, Jr. , Arija A. Bergmanis , Timothy J. Hagen , E. Ann Hallinan , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , Mahima Trivedi , R. Keith Webber , Sofya Tsymbalov , Rolando E. Gapud
发明人: Donald W. Hansen, Jr. , Arija A. Bergmanis , Timothy J. Hagen , E. Ann Hallinan , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Barnett S. Pitzele , Foe S. Tjoeng , Mihaly V. Toth , Mahima Trivedi , R. Keith Webber , Sofya Tsymbalov , Rolando E. Gapud
IPC分类号: A61K31/41 , A61K31/4166 , A61K31/4245 , A61K31/433 , A61K31/535 , A61K31/5377 , A61P9/02 , A61P43/00 , C07D233/96 , C07D271/06 , C07D271/07 , C07D273/04 , C07D285/08 , C07D291/04 , C07D271/113
CPC分类号: C07D291/04 , C07D233/96 , C07D271/07 , C07D273/04 , C07D285/08
摘要: 1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
摘要翻译: 可用作一氧化氮合酶抑制剂的1,2,4-恶二唑啉和1,2,4-氧杂二氮杂环丁烷杂环衍生物。
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6.
公开(公告)号:US06576780B1
公开(公告)日:2003-06-10
申请号:US09687353
申请日:2000-10-13
申请人: Rolando E. Gapud , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Barnett S. Pitzele , Suzanne S. Metz , R. Keith Webber , Foe S. Tjoeng , Robert E. Manning , Mihaly V. Toth
发明人: Rolando E. Gapud , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Barnett S. Pitzele , Suzanne S. Metz , R. Keith Webber , Foe S. Tjoeng , Robert E. Manning , Mihaly V. Toth
IPC分类号: C07F708
CPC分类号: C07D233/64 , C07C257/14 , C07C259/14 , C07C275/16 , C07C313/28 , C07C323/60 , C07C327/22 , C07C329/02 , C07C329/06 , C07C333/04 , C07C391/00 , C07D223/12 , C07D261/08 , C07F7/081
摘要: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
摘要翻译: 本发明公开了可用作一氧化氮合酶抑制剂的羟基脒基衍生物。
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7.
公开(公告)号:US06207708B1
公开(公告)日:2001-03-27
申请号:US09038292
申请日:1998-03-11
申请人: Rolando E. Gapud , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Barnett S. Pitzele , Suzanne S. Metz , R. Keith Webber , Foe S. Tjoeng , Robert E. Manning , Mihaly V. Toth
发明人: Rolando E. Gapud , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Barnett S. Pitzele , Suzanne S. Metz , R. Keith Webber , Foe S. Tjoeng , Robert E. Manning , Mihaly V. Toth
IPC分类号: A61K3119
CPC分类号: C07D233/64 , C07C257/14 , C07C259/14 , C07C275/16 , C07C313/28 , C07C323/60 , C07C327/22 , C07C329/02 , C07C329/06 , C07C333/04 , C07C391/00 , C07D223/12 , C07D261/08 , C07F7/081
摘要: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
摘要翻译: 本发明公开了可用作一氧化氮合酶抑制剂的羟基脒基衍生物。
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8.
公开(公告)号:US6011028A
公开(公告)日:2000-01-04
申请号:US913838
申请日:1998-03-27
申请人: Donald W. Hansen, Jr. , E. Ann. Hallinan , Timothy J. Hagen , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Dale P. Spangler , Mihaly V. Toth , Kam F. Fok , Arija A. Bergmanis , R. Keith Webber , Mahima Trivedi , Foe S. Tjoeng , Barnett S. Pitzele
发明人: Donald W. Hansen, Jr. , E. Ann. Hallinan , Timothy J. Hagen , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Dale P. Spangler , Mihaly V. Toth , Kam F. Fok , Arija A. Bergmanis , R. Keith Webber , Mahima Trivedi , Foe S. Tjoeng , Barnett S. Pitzele
IPC分类号: C07D319/06 , A61K31/045 , A61K31/12 , A61K31/15 , A61K31/165 , A61K31/19 , A61K31/35 , A61K31/351 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/42 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/451 , A61K31/55 , A61P9/00 , A61P25/00 , A61P25/30 , A61P29/00 , A61P43/00 , C07C251/44 , C07D207/22 , C07D211/72 , C07D211/76 , C07D223/10 , C07D223/12 , C07D225/02 , C07D309/06 , C07D333/16 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D521/00 , C07D267/06 , A61K31/33 , A61K31/395 , C07D281/02
CPC分类号: C07D249/08 , C07D207/22 , C07D211/72 , C07D223/12 , C07D225/02 , C07D231/12 , C07D233/56 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要: The current invention discloses useful amidino derivative useful as nitric oxide synthase inhibitors.
摘要翻译: PCT No.PCT / US96 / 05315 Sec。 371日期:1998年3月27日 102(e)1998年3月27日PCT 1996年4月19日PCT PCT。 出版物WO96 / 33175 日期1996年10月24日本发明公开了可用于一氧化氮合酶抑制剂的有用的脒基衍生物。
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公开(公告)号:US6043261A
公开(公告)日:2000-03-28
申请号:US199899
申请日:1998-11-25
申请人: Donald W. Hansen, Jr. , E. Ann Hallinan , Timothy J. Hagen , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Dale P. Spangler , Mihaly V. Toth , Kam F. Fok , Arija A. Bergmanis , R. Keith Webber , Mahima Trivedi , Foe S. Tjoeng , Barnett S. Pitzele
发明人: Donald W. Hansen, Jr. , E. Ann Hallinan , Timothy J. Hagen , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Dale P. Spangler , Mihaly V. Toth , Kam F. Fok , Arija A. Bergmanis , R. Keith Webber , Mahima Trivedi , Foe S. Tjoeng , Barnett S. Pitzele
IPC分类号: C07D319/06 , A61K31/045 , A61K31/12 , A61K31/15 , A61K31/165 , A61K31/19 , A61K31/35 , A61K31/351 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/42 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/451 , A61K31/55 , A61P9/00 , A61P25/00 , A61P25/30 , A61P29/00 , A61P43/00 , C07C251/44 , C07D207/22 , C07D211/72 , C07D211/76 , C07D223/10 , C07D223/12 , C07D225/02 , C07D309/06 , C07D333/16 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D521/00 , A01W57/00
CPC分类号: C07D249/08 , C07D207/22 , C07D211/72 , C07D223/12 , C07D225/02 , C07D231/12 , C07D233/56 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要: The current invention discloses useful pyrrolodino imidine derivatives useful as nitric oxide synthase inhibitors.
摘要翻译: 本发明公开了可用作一氧化氮合酶抑制剂的有用的吡咯烷亚胺衍生物。
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10.Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译: 可用作一氧化氮合酶抑制剂的亚氨基吡咯烷衍生物公开(公告)号:US06448286B1
公开(公告)日:2002-09-10
申请号:US09123720
申请日:1998-07-28
申请人: Donald W. Hansen, Jr. , Mark G. Currie , E. Ann Hallinan , Kam F. Fok , Timothy J. Hagen , Arija A. Bergmanis , Steven W. Kramer , Len F. Lee , Suzanne Metz , William M. Moore , Karen B. Peterson , Barnett S. Pitzele , Dale P. Spangler , R. Keith Webber , Mihaly V. Toth , Mahima Trivedi , Foe S. Tjoeng
发明人: Donald W. Hansen, Jr. , Mark G. Currie , E. Ann Hallinan , Kam F. Fok , Timothy J. Hagen , Arija A. Bergmanis , Steven W. Kramer , Len F. Lee , Suzanne Metz , William M. Moore , Karen B. Peterson , Barnett S. Pitzele , Dale P. Spangler , R. Keith Webber , Mihaly V. Toth , Mahima Trivedi , Foe S. Tjoeng
IPC分类号: A61K3154
CPC分类号: C07D213/06 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/505 , A61K31/535 , A61K31/54 , A61K31/55 , C07D207/22 , C07D209/44 , C07D211/72 , C07D211/74 , C07D215/38 , C07D217/22 , C07D221/22 , C07D221/24 , C07D223/12 , C07D225/02 , C07D233/46 , C07D239/12 , C07D239/14 , C07D263/28 , C07D265/08 , C07D277/18 , C07D279/06 , C07D405/06
摘要: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
摘要翻译: 本发明公开了含有用作一氧化氮合酶抑制剂的脒基衍生物的有用的药物组合物。
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