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1.发明申请Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US20070060598A1
公开(公告)日：2007-03-15
申请号：US11411413
申请日：2006-04-26
申请人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： A61K31/52 , C07D473/14
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，包含有效量的组合物 的氨基嘌呤化合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关的方法 条件，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。
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2.发明申请Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US20060287344A1
公开(公告)日：2006-12-21
申请号：US11332617
申请日：2006-01-12
申请人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： A61K31/52 , C07D473/14
CPC分类号： C07D473/00 , A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，组合物包含有效的 氨基嘌呤化合物的量和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉 - 相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。
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3.发明授权Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US07723340B2
公开(公告)日：2010-05-25
申请号：US11332617
申请日：2006-01-12
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole
IPC分类号： C07D473/32 , A61K31/52 , A61F2/82 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48
CPC分类号： C07D473/00 , A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症 ，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的 氨基嘌呤化合物对需要的患者。
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4.发明授权Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US08101588B2
公开(公告)日：2012-01-24
申请号：US12404413
申请日：2009-03-16
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： C07D473/32 , C07F5/02 , A61K31/52 , A61K31/69 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。
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5.发明申请公开(公告)号：US20090312320A1
公开(公告)日：2009-12-17
申请号：US12540013
申请日：2009-08-12
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole
CPC分类号： C07D473/00 , A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症 ，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的 氨基嘌呤化合物对需要的患者。
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6.发明申请HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权羟基取代的氨基酸，其组合物及其处理方法公开(公告)号：US20090275564A1
公开(公告)日：2009-11-05
申请号：US12404413
申请日：2009-03-16
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： A61K31/52 , C07D473/16 , C07D413/14 , C07D243/08 , A61K31/5377 , A61K31/551 , A61P37/00 , A61P35/00 , A61P9/00
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。
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7.发明授权Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US07521446B2
公开(公告)日：2009-04-21
申请号：US11411413
申请日：2006-04-26
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： C07D473/32 , A61K31/52 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。
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公开(公告)号：US06306897B1
公开(公告)日：2001-10-23
申请号：US09354550
申请日：1999-07-15
申请人： Fatih M. Uckun , Elise Sudbeck
发明人： Fatih M. Uckun , Elise Sudbeck
IPC分类号： A61K3135
CPC分类号： C07D493/04 , A61K31/352 , A61K31/37 , C07D493/14
摘要： The invention provides calanolide compounds used as Tec family/BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising calanolide Tec family/BTK inhibitors.
摘要翻译： 本发明提供用作Tec家族/ BTK抑制剂的calanolide化合物，其鉴定和使用方法，以及包含calanolide Tec家族/ BTK抑制剂的药物组合物。
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公开(公告)号：US20060276491A9
公开(公告)日：2006-12-07
申请号：US10715773
申请日：2003-11-17
申请人： Fatih Uckun , Elise Sudbeck , Marina Cetkovic , Ravi Malaviya , Xing-Ping Liu
发明人： Fatih Uckun , Elise Sudbeck , Marina Cetkovic , Ravi Malaviya , Xing-Ping Liu
IPC分类号： A61K31/517 , C07D239/72
CPC分类号： A61K31/00 , A61K31/505 , A61K31/517 , C07D239/74 , C07D239/94
摘要： The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
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公开(公告)号：US20050187233A1
公开(公告)日：2005-08-25
申请号：US11024364
申请日：2004-12-28
申请人： Faith Uckun , Ravi Malaviya , Elise Sudbeck
发明人： Faith Uckun , Ravi Malaviya , Elise Sudbeck
IPC分类号： A61K31/517
CPC分类号： A61K31/517
摘要： Inhibitors of JAK3 kinase for the treatment of allergy, and others are described.
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