公开(公告)号：US20090312320A1

公开(公告)日：2009-12-17

申请号：US12540013

申请日：2009-08-12

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S.S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright ,  Ian Henderson ,  Andrew G. Cole

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S.S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright ,  Ian Henderson ,  Andrew G. Cole

IPC分类号： A61K31/52 ,  A61K31/5377 ,  A61P29/00 ,  A61P35/00 ,  A61P9/00 ,  A61P25/00

CPC分类号： C07D473/00 ,  A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症 ，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的 氨基嘌呤化合物对需要的患者。

公开(公告)号：US20090275564A1

公开(公告)日：2009-11-05

申请号：US12404413

申请日：2009-03-16

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S.S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S.S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： A61K31/52 ,  C07D473/16 ,  C07D413/14 ,  C07D243/08 ,  A61K31/5377 ,  A61K31/551 ,  A61P37/00 ,  A61P35/00 ,  A61P9/00

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。

公开(公告)号：US07723340B2

公开(公告)日：2010-05-25

申请号：US11332617

申请日：2006-01-12

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright ,  Ian Henderson ,  Andrew G. Cole

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright ,  Ian Henderson ,  Andrew G. Cole

IPC分类号： C07D473/32 ,  A61K31/52 ,  A61F2/82 ,  A61P3/10 ,  A61P11/00 ,  C07D239/50 ,  C07D239/48

CPC分类号： C07D473/00 ,  A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症 ，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的 氨基嘌呤化合物对需要的患者。

公开(公告)号：US08101588B2

公开(公告)日：2012-01-24

申请号：US12404413

申请日：2009-03-16

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： C07D473/32 ,  C07F5/02 ,  A61K31/52 ,  A61K31/69 ,  A61P3/10 ,  A61P11/00 ,  C07D239/50 ,  C07D239/48

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。

公开(公告)号：US07521446B2

公开(公告)日：2009-04-21

申请号：US11411413

申请日：2006-04-26

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： C07D473/32 ,  A61K31/52 ,  A61P3/10 ,  A61P11/00 ,  C07D239/50 ,  C07D239/48

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。

公开(公告)号：US20070060598A1

公开(公告)日：2007-03-15

申请号：US11411413

申请日：2006-04-26

申请人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： A61K31/52 ,  C07D473/14

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，包含有效量的组合物 的氨基嘌呤化合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关的方法 条件，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。

公开(公告)号：US20060287344A1

公开(公告)日：2006-12-21

申请号：US11332617

申请日：2006-01-12

申请人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： A61K31/52 ,  C07D473/14

CPC分类号： C07D473/00 ,  A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，组合物包含有效的 氨基嘌呤化合物的量和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉 - 相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。

公开(公告)号：US09311647B2

公开(公告)日：2016-04-12

申请号：US11877527

申请日：2007-10-23

申请人： Carnet Williams ,  Olin Lagon ,  Kevin Hughes

发明人： Carnet Williams ,  Olin Lagon ,  Kevin Hughes

IPC分类号： G06F3/048 ,  G06Q30/02 ,  G06Q20/10 ,  G06Q20/40

CPC分类号： G06Q30/02 ,  G06Q20/10 ,  G06Q20/40

摘要： A system and computer implemented method for providing a widget are described. The method and system include receiving a configuration of the widget and rendering the widget on a site. The widget is for dynamically displaying multimedia content, is embeddable, and is copyable. The configuration includes an event with which the widget is associated. The multimedia content includes at least one updatable tracking mechanism for the event.

摘要翻译： 描述了一种用于提供小窗口的系统和计算机实现的方法。 该方法和系统包括接收小部件的配置并在站点上呈现小部件。 该小部件用于动态显示多媒体内容，是可嵌入的，并且是可复制的。 该配置包括与该widget相关联的事件。 多媒体内容包括用于该事件的至少一个可更新跟踪机构。

公开(公告)号：US08700802B2

公开(公告)日：2014-04-15

申请号：US13179102

申请日：2011-07-08

申请人： Carnet Williams ,  Kevin Hughes ,  Matthew McNeely

发明人： Carnet Williams ,  Kevin Hughes ,  Matthew McNeely

IPC分类号： G06F15/16 ,  G06F15/173

CPC分类号： H04N21/235 ,  H04N21/234309 ,  H04N21/23439 ,  H04N21/4782 ,  H04N21/6377 ,  H04N21/6543 ,  H04N21/812

摘要： Computer-implemented methods and systems for providing dynamic content to users are described. The dynamic content is received from a developer. A plurality of dynamic representations of the dynamic content is provided. The plurality of dynamic representations corresponds to a plurality of dynamic formats. Logic corresponding to the plurality of dynamic representations is provided to the developer.

摘要翻译： 描述用于向用户提供动态内容的计算机实现的方法和系统。 动态内容是从开发人员收到的。 提供动态内容的多个动态表示。 多个动态表示对应于多个动态格式。 将与多个动态表示相对应的逻辑提供给开发者。

公开(公告)号：US20100031147A1

公开(公告)日：2010-02-04

申请号：US12511728

申请日：2009-07-29

申请人： Carnet Williams ,  Kevin Hughes ,  Matthew McNeely

发明人： Carnet Williams ,  Kevin Hughes ,  Matthew McNeely

IPC分类号： G06F3/00 ,  G06F3/048 ,  G06F15/16

CPC分类号： G06F16/40 ,  G06F16/958

摘要： Computer-implemented methods and systems for providing a copy of a widget for a user are described. The widget is copyable, for dynamically displaying multimedia content, has a widget owner, corresponds to embeddable code, and is viewable on a site by the user. The method and system include receiving from the user a request for mixing the widget to provide the copy. The copy is a customized copy of the widget. The method and system also include receiving at least one change to the widget as viewed by the user and storing the at least one change in a memory and separate from the embeddable code. The customized copy is renderable based on the embeddable code and the at least one change.

摘要翻译： 描述了用于为用户提供小部件的副本的计算机实现的方法和系统。 小部件是可复制的，用于动态显示多媒体内容，具有小部件所有者，对应于可嵌入代码，并且可由用户在站点上查看。 该方法和系统包括从用户接收用于混合小部件以提供副本的请求。 该副本是窗口小部件的自定义副本。 所述方法和系统还包括：在由用户观察时接收对窗口小部件的至少一个改变，并且将所述至少一个改变存储在存储器中并与可嵌入代码分离。 基于可嵌入代码和至少一个更改，可自定义副本可呈现。