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    Method for immobilizing glycoprotein
    2.
    发明授权
    Method for immobilizing glycoprotein 有权
    糖蛋白固定方法

    公开(公告)号：US08153387B2

    公开(公告)日：2012-04-10

    申请号：US12490953

    申请日：2009-06-24

    申请人： Chun-Cheng Lin ,  Mu-Lin Chen ,  Po-Chiao Lin ,  Yu-Ju Chen ,  Shu-Hua Chen

    发明人： Chun-Cheng Lin ,  Mu-Lin Chen ,  Po-Chiao Lin ,  Yu-Ju Chen ,  Shu-Hua Chen

    IPC分类号： G01N33/53

    CPC分类号： C07K16/18 ,  C07K17/14 ,  C07K2317/41 ,  C07K2317/52 ,  G01N33/54353

    摘要： A method for immobilizing glycoprotein is disclosed. A surface is provided. Next, a boronic acid is contacted to the surface. The boronic acid is represented as Y—R—B—(OH)2 and includes a boronic acid group (B—(OH)2), a linker R, and a functional group Y, in which the boronic acid is bonded to the surface via the functional group Y. A glycoprotein is contacted to the boronic acid, wherein two spatially adjacent hydroxyl groups of a carbohydrate chain form a boronate ester with the boronic acid group of the boronic acid to immobilize the glycoprotein. The goal of site-specific and covalent protein immobilization without interfering the binding affinity of an antibody to antigen may be thus achieved with the reaction of boronic acid and the carbohydrate chain of Fc region.

    摘要翻译： 公开了一种固定糖蛋白的方法。 提供一个表面。 接下来，硼酸与表面接触。 硼酸被表示为Y-R-B-（OH）2，并且包括硼酸基团（B-（OH）2），连接体R和官能团Y，其中硼酸键合到 通过官能团Y表面。糖蛋白与硼酸接触，其中碳水化合物链的两个空间上相邻的羟基与硼酸的硼酸基团形成硼酸酯以固定糖蛋白。 因此可以通过硼酸和Fc区的碳水化合物链的反应来实现位点特异性和共价蛋白固定而不干扰抗体对抗原的结合亲和力的目标。

    Testing jig of electronic signal
    3.
    发明申请
    Testing jig of electronic signal 审中-公开
    电子信号测试夹具

    公开(公告)号：US20080122472A1

    公开(公告)日：2008-05-29

    申请号：US11522371

    申请日：2006-09-18

    申请人： Shu-Hua Chen

    发明人： Shu-Hua Chen

    IPC分类号： G01R31/26

    CPC分类号： G01R1/0483

    摘要： A testing jig of electronic signal is disclosed. The testing jig of electronic signal capable of providing electrical connection between a plurality of contact pads of the circuit board and a plurality of ball-shaped leads of the ball-grid-array packaging device in order to perform testing with respect to the ball-grid-array packaging device includes a connecting interface and at least a conducting gel. The connecting interface has a plurality of guiding connecting devices, each of them is one-to-one correspondent to the plurality of contact pads wherein each of the guiding connecting devices is aligned with and electrically connected to the contact pad. The conducting gel has a first side surface and a second side surface. The first side surface being bonded to the connecting interface is connected to the other end of the guiding connecting devices while the second side surface is bonded and connected to the plurality of ball-shaped leads. The conducting gel having a plurality of conducting wires makes the first side surface and the second side surface perform electrical connection.

    摘要翻译： 公开了一种电子信号测试夹具。 电子信号的测试夹具能够提供电路板的多个接触焊盘与球栅阵列封装装置的多个球形引线之间的电连接，以便执行相对于球栅的测试 射线包装装置包括连接界面和至少导电凝胶。 连接接口具有多个引导连接装置，每个引导连接装置与多个接触焊盘相对应地一一对应，其中每个引导连接装置与接触焊盘对准并电连接。 导电凝胶具有第一侧表面和第二侧表面。 接合到连接接口的第一侧表面连接到引导连接装置的另一端，而第二侧表面被接合并连接到多个球形引线。 具有多根导线的导电凝胶使得第一侧面和第二侧面进行电连接。