-
公开(公告)号:US06743794B2
公开(公告)日:2004-06-01
申请号:US10130800
申请日:2002-05-21
申请人: Rosanne Bonjouklian , Jeffrey Daniel Cohen , Joseph Michael Gruber , Douglas Webb Johnson , Louis Nickolaus Jungheim , Julian Stanley Kroin , Peter Ambrose Lander , Ho-Shen Lin , Mark Christopher Lohman , Brian Stephen Muehl , Bryan Hurst Norman , Vinod Francis Patel , Michael Enrico Richett , Kenneth Jeff Thrasher , Sreenivasarao Vepachedu , Wesley Todd White , Yongping Xie , Jeremy Schulenburg York , Brandon Lee Parkhurst , Qiupang Wang
发明人: Rosanne Bonjouklian , Jeffrey Daniel Cohen , Joseph Michael Gruber , Douglas Webb Johnson , Louis Nickolaus Jungheim , Julian Stanley Kroin , Peter Ambrose Lander , Ho-Shen Lin , Mark Christopher Lohman , Brian Stephen Muehl , Bryan Hurst Norman , Vinod Francis Patel , Michael Enrico Richett , Kenneth Jeff Thrasher , Sreenivasarao Vepachedu , Wesley Todd White , Yongping Xie , Jeremy Schulenburg York , Brandon Lee Parkhurst , Qiupang Wang
IPC分类号: A61K31496
CPC分类号: C07D471/04
摘要: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
-
公开(公告)号:US07101891B2
公开(公告)日:2006-09-05
申请号:US10473236
申请日:2002-03-27
IPC分类号: C07D498/14 , A61K31/435
CPC分类号: C07D498/04
摘要: The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1
摘要翻译: 本发明涉及式(I)化合物,其可用于抑制耐药性,其中抗药性部分或全部由MRP1赋予
-
公开(公告)号:US06992097B2
公开(公告)日:2006-01-31
申请号:US10453833
申请日:2003-06-03
申请人: Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , Jeffrey Daniel Cohen , James Densmore Copp , Kennan Joseph Fahey , William Harlan Gritton , Louis Nickolaus Jungheim , Joseph Henry Kennedy , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , David Edward Seyler , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
发明人: Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , Jeffrey Daniel Cohen , James Densmore Copp , Kennan Joseph Fahey , William Harlan Gritton , Louis Nickolaus Jungheim , Joseph Henry Kennedy , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , David Edward Seyler , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
IPC分类号: A61K31/415 , C07D233/44
CPC分类号: C07D207/416 , A61K45/06 , C07D207/16 , C07D207/42 , C07D231/40 , C07D233/88 , C07D401/06 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/06 , C07D487/08
摘要: This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译: 本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。 本发明还涉及用于合成所述化合物的新中间体,以及在这些合成中使用的新方法。 还包括治疗哺乳动物的方法,其包括施用所述化合物。
-
公开(公告)号:US07037921B2
公开(公告)日:2006-05-02
申请号:US10473241
申请日:2002-03-28
IPC分类号: C07D498/12 , A61K31/435
CPC分类号: C07D498/14
摘要: The present invention relates to a compound of Formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
摘要翻译: 本发明涉及式(I)化合物,其可用于抑制MRP1部分或全部赋予抗性的抗性肿瘤。
-
公开(公告)号:US07125840B2
公开(公告)日:2006-10-24
申请号:US10380867
申请日:2001-10-09
申请人: Jeffrey Alan Dodge , Britta Evers , Louis Nickolaus Jungheim , Brian Stephen Muehl , Gerd Ruehter , Kenneth Jeff Thrasher
发明人: Jeffrey Alan Dodge , Britta Evers , Louis Nickolaus Jungheim , Brian Stephen Muehl , Gerd Ruehter , Kenneth Jeff Thrasher
IPC分类号: A01N37/18
CPC分类号: C07D275/06 , A61K31/4015 , A61K31/4025 , A61K31/404 , A61K31/425 , C07D209/54 , C07D401/10 , C07D409/04 , C07D409/10 , C07D417/04 , C07D417/06 , C07D417/10
摘要: This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译: 本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。 本发明还涉及用于合成所述化合物的新中间体,以及在这些合成中使用的新方法。 还包括治疗哺乳动物的方法,其包括施用所述化合物。
-
6.Compounds, methods and formulations for the oral delivery of a glucagon-like peptide (GLP-1) compound or a melanocortin-4 receptor (MC4) agonist peptide 有权
标题翻译: 用于口服递送胰高血糖素样肽(GLP-1)化合物或黑皮质素-4受体(MC4)激动剂肽的化合物,方法和制剂公开(公告)号:US08552039B2
公开(公告)日:2013-10-08
申请号:US12636244
申请日:2009-12-11
申请人: Robert Jason Herr , Louis Nickolaus Jungheim , John McNeil McGill , Kenneth Jeff Thrasher , Muralikrishna Valluri
发明人: Robert Jason Herr , Louis Nickolaus Jungheim , John McNeil McGill , Kenneth Jeff Thrasher , Muralikrishna Valluri
IPC分类号: A61K31/421 , C07D263/34
CPC分类号: C07D263/48 , A61K31/4164 , A61K38/22 , A61K38/26 , A61K47/22 , C07D233/64 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要: The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide.
摘要翻译: 本发明涉及可用于口服递送GLP-1化合物或MC4激动剂肽的新化合物,方法和制剂。
-
7.Compounds, methods and formulations for the oral delivery of a glucagon-like peptide (Glp)-1 compound or a melanocortin-4 receptor (Mc4) agonist peptide 有权
标题翻译: 用于口服递送胰高血糖素样肽(Glp)-1化合物或黑皮质素-4受体(Mc4)激动剂肽的化合物,方法和制剂公开(公告)号:US08546581B2
公开(公告)日:2013-10-01
申请号:US13087255
申请日:2011-04-14
申请人: Louis Nickolaus Jungheim , John Mcneill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Muralikrishna Valluri
发明人: Louis Nickolaus Jungheim , John Mcneill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Muralikrishna Valluri
IPC分类号: C07D271/06 , C07D401/00 , C07D409/00
CPC分类号: C07D233/64 , A61K47/22 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要: The present application relates to novel compounds, methods and formulations useful for the oral delivery of a glucagon like peptide-1 compound or a melanocortin 4 receptor agonist peptide.
摘要翻译: 本申请涉及可用于胰高血糖素样肽-1化合物或黑皮质素4受体激动剂肽的口服递送的新化合物,方法和制剂。
-
8.Compounds, methods and formulations for the oral delivery of a glucagon-like peptide (GLP)-1 compound or a melanocortin-4 receptor (MC4) agonist peptide 有权
标题翻译: 胰高血糖素样肽(GLP)-1化合物或黑皮质素-4受体(MC4)激动剂肽的口服递送的化合物,方法和制剂公开(公告)号:US07947841B2
公开(公告)日:2011-05-24
申请号:US12263722
申请日:2008-11-03
申请人: Louis Nickolaus Jungheim , John McNeill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Valluri Muralikrishna
发明人: Louis Nickolaus Jungheim , John McNeill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Valluri Muralikrishna
IPC分类号: C07D263/34 , C07D213/00 , C07D409/00
CPC分类号: C07D233/64 , A61K47/22 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要: The present application relates to novel compounds, methods and formulations useful for the oral delivery of a glucagon like peptide-1 compound or a melanocortin 4 receptor agonist peptide.
摘要翻译: 本申请涉及可用于胰高血糖素样肽-1化合物或黑皮质素4受体激动剂肽的口服递送的新化合物,方法和制剂。
-
9.Compounds, Methods and Formulations for the Oral Delivery of a Glucagon-Like Peptide (Glp)-1 Compound or a Melanocortin-4 Receptor (Mc4) Agonist Peptide 有权
标题翻译: 口服胰岛素样肽(Glp)-1化合物或黑皮质素-4受体(Mc4)激动剂肽的口服递送的化合物,方法和制剂公开(公告)号:US20090239798A1
公开(公告)日:2009-09-24
申请号:US12263722
申请日:2008-11-03
申请人: Louis Nickolaus Jungheim , John McNeill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Muralikrishna Valluri
发明人: Louis Nickolaus Jungheim , John McNeill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Muralikrishna Valluri
IPC分类号: A61K38/22 , C07D413/04 , A61K38/12
CPC分类号: C07D233/64 , A61K47/22 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要: The present application relates to novel compounds, methods and formulations useful for the oral delivery of a glucagon like peptide-1 compound or a melanocortin 4 receptor agonist peptide.
摘要翻译: 本申请涉及可用于胰高血糖素样肽-1化合物或黑皮质素4受体激动剂肽的口服递送的新化合物,方法和制剂。
-
10.Compounds, Methods and Formulations for the Oral Delivery of a Glucagon-Like Peptide (Glp)-1 Compound or a Melanocortin-4 Receptor (Mc4) Agonist Peptide 有权
标题翻译: 口服胰岛素样肽(Glp)-1化合物或黑皮质素-4受体(Mc4)激动剂肽的口服递送的化合物,方法和制剂公开(公告)号:US20080214448A1
公开(公告)日:2008-09-04
申请号:US10566342
申请日:2004-08-18
申请人: Robert Jason Herr , Louis Nickolaus Jungheim , John McNeill McGill , Kenneth Jeff Thrasher , Muralikrishna Valluri
发明人: Robert Jason Herr , Louis Nickolaus Jungheim , John McNeill McGill , Kenneth Jeff Thrasher , Muralikrishna Valluri
IPC分类号: A61K38/22 , C07D277/30 , C07D263/44 , C07D233/56 , A61P43/00
CPC分类号: C07D263/48 , A61K31/4164 , A61K38/22 , A61K38/26 , A61K47/22 , C07D233/64 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要: The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide.
摘要翻译: 本发明涉及可用于口服递送GLP-1化合物或MC4激动剂肽的新化合物,方法和制剂。
-
-
-
-
-
-
-
-
-