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公开(公告)号：US20050288346A1
公开(公告)日：2005-12-29
申请号：US10524704
申请日：2003-08-22
IPC分类号： A61K31/41 , A61P25/00 , C07D257/02 , C07D257/04
CPC分类号： C07D257/04
摘要： The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
摘要翻译： 本发明涉及作为代谢型谷氨酸受体的增强剂（包括mGluR2受体）的化合物，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神病学障碍以及其中涉及代谢型谷氨酸受体的疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。
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2.发明申请公开(公告)号：US20080096935A1
公开(公告)日：2008-04-24
申请号：US11666072
申请日：2005-10-21
IPC分类号： A61K31/4412 , A61K31/4196 , A61K31/4152
CPC分类号： C07D213/30 , C07D207/32 , C07D213/65 , C07D213/70 , C07D231/12 , C07D235/18 , C07D249/08
摘要： The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
摘要翻译： 本发明涉及作为代谢型谷氨酸受体的增强剂（包括mGluR2受体）的化合物，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神病学障碍以及其中涉及代谢型谷氨酸受体的疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。
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公开(公告)号：US20130040983A1
公开(公告)日：2013-02-14
申请号：US13520548
申请日：2011-01-07
申请人： Jean-Michel Vernier , Patrick O'Connor , William Ripka , David Matthews , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
发明人： Jean-Michel Vernier , Patrick O'Connor , William Ripka , David Matthews , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
IPC分类号： C07D401/04 , C12N9/99 , A61P35/00 , C07D471/04 , A61K31/437 , A61K31/4439 , C07D401/14
CPC分类号： C07D401/04 , C07D471/04
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.
摘要翻译： 本文描述了用于抑制RAF基因介导的信号传导的化合物，药物组合物和方法。 所述化合物，药物组合物和方法可用于治疗人类疾病和病症。
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公开(公告)号：US20130012513A1
公开(公告)日：2013-01-10
申请号：US13520150
申请日：2011-01-06
申请人： Jean-Michel Vernier , John May , Patrick O'Connor , William Ripka , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
发明人： Jean-Michel Vernier , John May , Patrick O'Connor , William Ripka , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
IPC分类号： C07D277/30 , C12N5/07 , C07D413/12 , A61P35/00 , C07D263/32 , A61K31/421 , C07D417/12 , A61K31/496 , A61K31/426 , A61K31/5377
CPC分类号： C07D277/28 , C07D263/32 , C07D277/24 , C07D277/30
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary disease and disorders.
摘要翻译： 本文描述了用于抑制Hedgehog信号传导的化合物，药物组合物和方法。 所述化合物，药物组合物和方法可用于治疗人和兽医疾病和病症。
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公开(公告)号：US09174949B2
公开(公告)日：2015-11-03
申请号：US13520150
申请日：2011-01-06
申请人： Jean-Michel Vernier , John May , Patrick O'Connor , William Ripka , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
发明人： Jean-Michel Vernier , John May , Patrick O'Connor , William Ripka , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
IPC分类号： A61K31/496 , A61K31/5377 , A61K31/427 , C07D417/12 , C07D277/22 , C07D277/28 , C07D263/32 , C07D277/24 , C07D277/30
CPC分类号： C07D277/28 , C07D263/32 , C07D277/24 , C07D277/30
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary disease and disorders.
摘要翻译： 本文描述了用于抑制Hedgehog信号传导的化合物，药物组合物和方法。 所述化合物，药物组合物和方法可用于治疗人和兽医疾病和病症。
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公开(公告)号：US20070049591A1
公开(公告)日：2007-03-01
申请号：US11509508
申请日：2006-08-24
申请人： Anthony Pinkerton , Robert Davis , Timothy Gahman , J. Semple
发明人： Anthony Pinkerton , Robert Davis , Timothy Gahman , J. Semple
IPC分类号： A61K31/5377 , A61K31/522 , A61K31/52 , A61K31/519 , A61K31/503 , C07D487/02 , C07D473/02
CPC分类号： C07D471/04 , C07D209/30 , C07D473/34 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of MEK kinase and methods for the treatment or prevention of cellular proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.
摘要翻译： 本发明涉及可用作MEK激酶抑制剂的化合物和用于治疗或预防细胞增殖性疾病状态的方法，例如与MEK的多动症相关的病症以及由MEK级联调节的疾病。
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