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公开(公告)号:US20100267722A1
公开(公告)日:2010-10-21
申请号:US12761427
申请日:2010-04-16
申请人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
发明人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
IPC分类号: A61K31/5377 , C07D207/16 , A61K31/401 , A61P9/10 , A61P11/00 , A61P13/12 , C07D403/12 , A61K31/4178 , A61K31/496 , A61K31/501 , C07D413/12 , C07D487/04 , A61K31/407 , A61K31/4025
CPC分类号: C07D207/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/04
摘要: The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译: 本发明涉及式(I)化合物,其中A,R 1 -R 6如说明书和权利要求中所定义。 式(I)化合物可以用作药物。
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公开(公告)号:US08163793B2
公开(公告)日:2012-04-24
申请号:US12761427
申请日:2010-04-16
申请人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
发明人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
IPC分类号: C07D417/14 , C07D417/10 , C07D417/04 , C07D413/14 , C07D413/10 , C07D413/04 , C07D409/14 , C07D409/10 , C07D409/04 , C07D405/14 , C07D405/10 , C07D405/04 , C07D401/14 , C07D401/10 , C07D401/04 , C07D403/14 , C07D403/10 , C07D403/04 , C07D403/06 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D207/16 , A61K31/541 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/4025
CPC分类号: C07D207/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/04
摘要: The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译: 本发明涉及式(I)化合物,其中A,R 1 -R 6如说明书和权利要求中所定义。 式(I)化合物可以用作药物。
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公开(公告)号:US20100317647A1
公开(公告)日:2010-12-16
申请号:US12791914
申请日:2010-06-02
申请人: David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher , Rubén Alvarez Sánchez
发明人: David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher , Rubén Alvarez Sánchez
IPC分类号: A61K31/397 , A61K31/337 , A61K31/5386 , A61K31/5375 , A61K31/495 , A61K31/445 , C07D498/08 , C07D265/30 , C07D241/04 , C07D211/44 , C07D401/12 , C07D403/04 , A61P3/10 , A61P35/00 , A61P13/12 , A61P19/02 , A61P11/06 , A61P17/00
CPC分类号: C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D205/04 , C07D207/06 , C07D207/10 , C07D207/16 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/66 , C07D213/34 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D231/12 , C07D237/08 , C07D237/14 , C07D237/16 , C07D239/26 , C07D249/06 , C07D261/08 , C07D277/26 , C07D279/12 , C07D295/096 , C07D295/185 , C07D309/12 , C07D333/18 , C07D335/02 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/12 , C07D491/08 , C07D491/107
摘要: The invention relates to a compound of formula (I) wherein A1 and R1 to R5 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译: 本发明涉及式(I)化合物,其中A1和R1至R5如在说明书和权利要求书中所定义。 式(I)化合物可以用作药物。
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公开(公告)号:US20110071128A1
公开(公告)日:2011-03-24
申请号:US12886657
申请日:2010-09-21
申请人: Daniela Alberati , Rubén Alvarez Sánchez , Konrad Bleicher , Alexander Flohr , Katrin Groebke Zbinden , Matthias Koerner , Bernd Kuhn , Jens-Uwe Peters , Markus Rudolph
发明人: Daniela Alberati , Rubén Alvarez Sánchez , Konrad Bleicher , Alexander Flohr , Katrin Groebke Zbinden , Matthias Koerner , Bernd Kuhn , Jens-Uwe Peters , Markus Rudolph
IPC分类号: A61K31/553 , C07D471/04 , C07D487/04 , C07D491/107 , A61K31/437 , A61K31/5377 , A61K31/5025 , A61K31/496 , A61P25/18
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5025 , A61K31/5377 , A61K31/553 , C07D487/04
摘要: The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of various diseases, including central nervous system disorders such as Alzheimer's disease, Parkinson's disease, and schizophrenia.
摘要翻译: 本发明涉及式(I)的新咪唑并吡啶衍生物,其中R 1,R 2,R 3,R 4,R 5和A如说明书和权利要求书中所定义,以及其生理上可接受的盐和酯。 这些化合物抑制PDE10A,可用于治疗各种疾病,包括中枢神经系统疾病如阿尔茨海默病,帕金森病和精神分裂症。
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公开(公告)号:US20110237564A1
公开(公告)日:2011-09-29
申请号:US13049941
申请日:2011-03-17
申请人: Rubén Alvarez Sánchez , Konrad Bleicher , Alexander Flohr , Luca Gobbi , Katrin Groebke Zbinden , Matthias Koerner , Bernd Kuhn , Jens-Uwe Peters , Markus Rudolph
发明人: Rubén Alvarez Sánchez , Konrad Bleicher , Alexander Flohr , Luca Gobbi , Katrin Groebke Zbinden , Matthias Koerner , Bernd Kuhn , Jens-Uwe Peters , Markus Rudolph
IPC分类号: A61K31/519 , C07D487/04 , A61K31/5377 , A61K31/541 , C07D513/04 , A61P25/18
CPC分类号: C07D487/04 , C07D519/00
摘要: The invention is concerned with novel imidazopyrimidine derivatives of formula (I) wherein R1, R2 and R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as pharmaceuticals.
摘要翻译: 本发明涉及式(I)的新型咪唑并嘧啶衍生物,其中R 1,R 2和R 8如说明书和权利要求书中所定义,以及其生理上可接受的盐和酯。 这些化合物抑制PDE10A,可用作药物。
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公开(公告)号:US08017604B2
公开(公告)日:2011-09-13
申请号:US12886657
申请日:2010-09-21
申请人: Daniela Alberati , Rubén Alvarez Sánchez , Konrad Bleicher , Alexander Flohr , Katrin Groebke Zbinden , Matthias Koerner , Bernd Kuhn , Jens-Uwe Peters , Markus Rudolph
发明人: Daniela Alberati , Rubén Alvarez Sánchez , Konrad Bleicher , Alexander Flohr , Katrin Groebke Zbinden , Matthias Koerner , Bernd Kuhn , Jens-Uwe Peters , Markus Rudolph
IPC分类号: A61K31/535 , A61K31/44 , A01N43/42 , C07D491/02 , C07D498/02 , C07D413/00
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5025 , A61K31/5377 , A61K31/553 , C07D487/04
摘要: The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of various diseases, including central nervous system disorders such as Alzheimer's disease, Parkinson's disease, and schizophrenia.
摘要翻译: 本发明涉及式(I)的新咪唑并吡啶衍生物,其中R 1,R 2,R 3,R 4,R 5和A如说明书和权利要求书中所定义,以及其生理上可接受的盐和酯。 这些化合物抑制PDE10A,可用于治疗各种疾病,包括中枢神经系统疾病如阿尔茨海默病,帕金森病和精神分裂症。
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