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公开(公告)号:US08163793B2
公开(公告)日:2012-04-24
申请号:US12761427
申请日:2010-04-16
申请人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
发明人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
IPC分类号: C07D417/14 , C07D417/10 , C07D417/04 , C07D413/14 , C07D413/10 , C07D413/04 , C07D409/14 , C07D409/10 , C07D409/04 , C07D405/14 , C07D405/10 , C07D405/04 , C07D401/14 , C07D401/10 , C07D401/04 , C07D403/14 , C07D403/10 , C07D403/04 , C07D403/06 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D207/16 , A61K31/541 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/4025
CPC分类号: C07D207/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/04
摘要: The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译: 本发明涉及式(I)化合物,其中A,R 1 -R 6如说明书和权利要求中所定义。 式(I)化合物可以用作药物。
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公开(公告)号:US20100267722A1
公开(公告)日:2010-10-21
申请号:US12761427
申请日:2010-04-16
申请人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
发明人: Rubén Alvarez Sánchez , David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Peter Hartman , Guido Hartmann , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
IPC分类号: A61K31/5377 , C07D207/16 , A61K31/401 , A61P9/10 , A61P11/00 , A61P13/12 , C07D403/12 , A61K31/4178 , A61K31/496 , A61K31/501 , C07D413/12 , C07D487/04 , A61K31/407 , A61K31/4025
CPC分类号: C07D207/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/04
摘要: The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译: 本发明涉及式(I)化合物,其中A,R 1 -R 6如说明书和权利要求中所定义。 式(I)化合物可以用作药物。
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公开(公告)号:US20100317647A1
公开(公告)日:2010-12-16
申请号:US12791914
申请日:2010-06-02
申请人: David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher , Rubén Alvarez Sánchez
发明人: David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher , Rubén Alvarez Sánchez
IPC分类号: A61K31/397 , A61K31/337 , A61K31/5386 , A61K31/5375 , A61K31/495 , A61K31/445 , C07D498/08 , C07D265/30 , C07D241/04 , C07D211/44 , C07D401/12 , C07D403/04 , A61P3/10 , A61P35/00 , A61P13/12 , A61P19/02 , A61P11/06 , A61P17/00
CPC分类号: C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D205/04 , C07D207/06 , C07D207/10 , C07D207/16 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/66 , C07D213/34 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D231/12 , C07D237/08 , C07D237/14 , C07D237/16 , C07D239/26 , C07D249/06 , C07D261/08 , C07D277/26 , C07D279/12 , C07D295/096 , C07D295/185 , C07D309/12 , C07D333/18 , C07D335/02 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/12 , C07D491/08 , C07D491/107
摘要: The invention relates to a compound of formula (I) wherein A1 and R1 to R5 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译: 本发明涉及式(I)化合物,其中A1和R1至R5如在说明书和权利要求书中所定义。 式(I)化合物可以用作药物。
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公开(公告)号:US07893099B2
公开(公告)日:2011-02-22
申请号:US12791914
申请日:2010-06-02
申请人: David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher , Ruben Alvarez Sanchez
发明人: David Banner , Simona M. Ceccarelli , Uwe Grether , Wolfgang Haap , Hans Hilpert , Holger Kuehne , Harald Mauser , Jean-Marc Plancher , Ruben Alvarez Sanchez
IPC分类号: A61K31/415 , A61K31/5375 , A61K31/54 , A61K31/495 , A61K31/50 , A61K31/40 , A61K31/435 , C07D231/10 , C07D265/30 , C07D279/12 , C07D205/00 , C07D211/00 , C07D213/00 , C07C255/01
CPC分类号: C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D205/04 , C07D207/06 , C07D207/10 , C07D207/16 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/66 , C07D213/34 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D231/12 , C07D237/08 , C07D237/14 , C07D237/16 , C07D239/26 , C07D249/06 , C07D261/08 , C07D277/26 , C07D279/12 , C07D295/096 , C07D295/185 , C07D309/12 , C07D333/18 , C07D335/02 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/12 , C07D491/08 , C07D491/107
摘要: The invention relates to a compound of formula (I) wherein A1 and R1 to R5 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译: 本发明涉及式(I)化合物,其中A1和R1至R5如在说明书和权利要求书中所定义。 式(I)化合物可以用作药物。
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公开(公告)号:US08524710B2
公开(公告)日:2013-09-03
申请号:US13279364
申请日:2011-10-24
申请人: David Banner , Uwe Grether , Wolfgang Haap , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
发明人: David Banner , Uwe Grether , Wolfgang Haap , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
IPC分类号: C07D401/04 , C07D487/04 , A61K31/506
CPC分类号: C07D403/04 , C07D401/04 , C07D413/04 , C07D487/04
摘要: The invention relates to a compound of formula (I) wherein A1 to A4 and R1 to R6 are defined as in the description and in the claims. The compound of formula (I) can be used, for example, as inhibitors of the cysteine protease cathepsin.
摘要翻译: 本发明涉及式(I)化合物,其中A1至A4和R1至R6如在说明书和权利要求书中所定义。 式(I)化合物可用作例如半胱氨酸蛋白酶组织蛋白酶的抑制剂。
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公开(公告)号:US20120115843A1
公开(公告)日:2012-05-10
申请号:US13279364
申请日:2011-10-24
申请人: David Banner , Uwe Grether , Wolfgang Haap , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
发明人: David Banner , Uwe Grether , Wolfgang Haap , Holger Kuehne , Harald Mauser , Jean-Marc Plancher
IPC分类号: A61K31/5377 , A61K31/506 , C07D403/04 , A61P9/00 , A61P3/10 , A61P9/10 , A61P35/00 , C07D413/14 , A61K31/497
CPC分类号: C07D403/04 , C07D401/04 , C07D413/04 , C07D487/04
摘要: The invention relates to a compound of formula (I) wherein A1 to A4 and R1 to R6 are defined as in the description and in the claims. The compound of formula (I) can be used, for example, as inhibitors of the cysteine protease cathepsin.
摘要翻译: 本发明涉及式(I)化合物,其中A1至A4和R1至R6如在说明书和权利要求书中所定义。 式(I)化合物可用作例如半胱氨酸蛋白酶组织蛋白酶的抑制剂。
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公开(公告)号:US06900227B2
公开(公告)日:2005-05-31
申请号:US10626681
申请日:2003-07-24
申请人: Alexander Alanine , Konrad Bleicher , Wolfgang Guba , Wolfgang Haap , Dagmar Kube , Thomas Luebbers , Jean-Marc Plancher , Olivier Roche , Mark Rogers-Evans , Gisbert Schneider , Jochen Zuegge
发明人: Alexander Alanine , Konrad Bleicher , Wolfgang Guba , Wolfgang Haap , Dagmar Kube , Thomas Luebbers , Jean-Marc Plancher , Olivier Roche , Mark Rogers-Evans , Gisbert Schneider , Jochen Zuegge
IPC分类号: A61K31/36 , C07D317/46 , C07D317/54 , C07D317/62 , C07D317/72 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/06 , C07D451/06 , C07D491/10 , A61K31/445
CPC分类号: C07D317/46 , C07D317/72 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/06 , C07D451/06 , C07D491/10
摘要: The present invention relates to compounds of the general formula and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such as obesity by selective modulation of CB1 receptors.
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公开(公告)号:US07576088B2
公开(公告)日:2009-08-18
申请号:US11062973
申请日:2005-02-22
申请人: Alexander Alanine , Konrad Bleicher , Wolfgang Guba , Wolfgang Haap , Dagmar Kube , Thomas Luebbers , Jean-Marc Plancher , Olivier Roche , Mark Rogers-Evans , Gisbert Schneider , Jochen Zuegge
发明人: Alexander Alanine , Konrad Bleicher , Wolfgang Guba , Wolfgang Haap , Dagmar Kube , Thomas Luebbers , Jean-Marc Plancher , Olivier Roche , Mark Rogers-Evans , Gisbert Schneider , Jochen Zuegge
IPC分类号: A61K31/496 , C07D411/02
CPC分类号: C07D317/46 , C07D317/72 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/06 , C07D451/06 , C07D491/10
摘要: The present invention relates to compounds of the general formula and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such as obesity by selective modulation of CB1 receptors.
摘要翻译: 本发明涉及通式的化合物及其药学上可接受的盐。 该化合物可用于通过选择性调节CB1受体来治疗和/或预防诸如肥胖症的疾病。
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公开(公告)号:US20050143373A1
公开(公告)日:2005-06-30
申请号:US11062973
申请日:2005-02-22
申请人: Alexander Alanine , Konrad Bleicher , Wolfgang Guba , Wolfgang Haap , Dagmar Kube , Thomas Luebbers , Jean-Marc Plancher , Olivier Roche , Mark Rogers-Evans , Gisbert Schneider , Jochen Zuegge
发明人: Alexander Alanine , Konrad Bleicher , Wolfgang Guba , Wolfgang Haap , Dagmar Kube , Thomas Luebbers , Jean-Marc Plancher , Olivier Roche , Mark Rogers-Evans , Gisbert Schneider , Jochen Zuegge
IPC分类号: A61K31/36 , C07D317/46 , C07D317/54 , C07D317/62 , C07D317/72 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/06 , C07D451/06 , C07D491/10 , A61K31/551 , A61K31/4025 , A61K31/452 , A61K31/496 , A61K31/5377 , C07D47/02
CPC分类号: C07D317/46 , C07D317/72 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/06 , C07D451/06 , C07D491/10
摘要: The present invention relates to compounds of the general formula and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such as obesity by selective modulation of CB1 receptors.
摘要翻译: 本发明涉及通式的化合物及其药学上可接受的盐。 该化合物可用于通过选择性调节CB1受体来治疗和/或预防诸如肥胖症的疾病。
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公开(公告)号:US07964633B2
公开(公告)日:2011-06-21
申请号:US11903580
申请日:2007-09-24
申请人: Wolfgang Haap , Paul Hebeisen , Eric A. Kitas , Philipp Christoph Kohler , Holger Kuehne , Armin Ruf
发明人: Wolfgang Haap , Paul Hebeisen , Eric A. Kitas , Philipp Christoph Kohler , Holger Kuehne , Armin Ruf
IPC分类号: A61K31/381 , C07D409/12
CPC分类号: C07C311/58 , C07D307/64 , C07D317/62 , C07D333/34 , C07D333/38
摘要: Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein L, R1, R2, m and n have the meaning given in claim 1 and which can be used in the form of pharmaceutical compositions.
摘要翻译: 式(I)化合物及其药学上可接受的盐和酯,其中L,R 1,R 2,m和n具有权利要求1中给出的含义,并且可以以药物组合物的形式使用。
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