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1.发明授权Nucleic acid constructs encoding reprogramming factors linked by self-cleaving peptides 有权编码通过自切割肽连接的重编程因子的核酸构建体公开(公告)号：US09497943B2
公开(公告)日：2016-11-22
申请号：US12997815
申请日：2009-06-15
IPC分类号： C12N15/00 , A01K67/027 , C12N5/074 , G01N33/50 , C12N15/86 , C12N15/85 , C12N5/0735 , C12N15/79
CPC分类号： C12N15/86 , A01K67/0271 , C07K14/4705 , C12N5/0606 , C12N5/0696 , C12N15/79 , C12N15/85 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/11 , C12N2506/115 , C12N2510/00 , C12N2740/15041 , C12N2740/15043 , C12N2740/16043 , C12N2799/027 , C12N2800/108 , C12N2840/203 , G01N33/5008
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
摘要翻译： 本公开涉及将一种或多种体细胞（例如部分分化或完全/终末分化的体细胞）重新编程为较少分化状态（例如多能或多能状态）的方法。 在进一步的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞细胞，包含本发明的重编程体细胞的嵌合动物，所述细胞的用途以及用于鉴定用于重编程体细胞的药物的方法。
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公开(公告)号：US20120028821A1
公开(公告)日：2012-02-02
申请号：US12997815
申请日：2009-06-15
CPC分类号： C12N15/86 , A01K67/0271 , C07K14/4705 , C12N5/0606 , C12N5/0696 , C12N15/79 , C12N15/85 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/11 , C12N2506/115 , C12N2510/00 , C12N2740/15041 , C12N2740/15043 , C12N2740/16043 , C12N2799/027 , C12N2800/108 , C12N2840/203 , G01N33/5008
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
摘要翻译： 本公开涉及将一种或多种体细胞（例如部分分化或完全/终末分化的体细胞）重新编程为较少分化状态（例如多能或多能状态）的方法。 在进一步的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞细胞，包含本发明的重编程体细胞的嵌合动物，所述细胞的用途以及用于鉴定用于重编程体细胞的药物的方法。
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公开(公告)号：US20100273259A1
公开(公告)日：2010-10-28
申请号：US12765472
申请日：2010-04-22
申请人： Krishanu Saha , Ying Mei , Said R. Bogatyrev , Daniel G. Anderson , Rudolf Jaenisch , Robert S. Langer , Morgan Alexander , Martyn Davies , Jing Yang , Christian J. Kastrup , Andrew Urquhart
发明人： Krishanu Saha , Ying Mei , Said R. Bogatyrev , Daniel G. Anderson , Rudolf Jaenisch , Robert S. Langer , Morgan Alexander , Martyn Davies , Jing Yang , Christian J. Kastrup , Andrew Urquhart
IPC分类号： C12N5/0797
CPC分类号： G01N23/2258 , C12N5/0068 , C12N2535/10 , H01J49/00
摘要： The present disclosure provides a device and a cell culture system comprising a substrate that generates significant chemical ion signatures adapted for culturing stem cells. This disclosure further provides unique surface properties, such as surface wettability, along with defined polymer microspot environments in an array, for effectively supporting the propagation and differentiation of human pluripotent stem cells in vitro. Methods of culturing, maintenance, differentiating stem cells as well as reprogramming somatic cells into stem cells using the device and the cell culture system with the suitable substrates, along with suitable culture media, are also provided.
摘要翻译： 本公开提供了一种装置和细胞培养系统，其包含生成适于培养干细胞的显着化学离子特征的底物。 本公开进一步提供独特的表面性质，例如表面润湿性，以及阵列中限定的聚合物微球环境，用于在体外有效支持人多能干细胞的繁殖和分化。 还提供了使用装置和具有合适底物的细胞培养系统以及合适的培养基将培养，维持，分化干细胞以及将体细胞重编程成干细胞的方法。
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公开(公告)号：US20100221827A1
公开(公告)日：2010-09-02
申请号：US12703015
申请日：2010-02-09
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/85 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2506/1307 , C12N2510/00 , C12N2830/003 , C12N2830/006
摘要： The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.
摘要翻译： 本发明提供了重编程体细胞产生多潜能或多潜能细胞的方法。 这些方法可用于各种目的，包括治疗或预防个体的医疗状况。 本发明进一步提供了用于鉴定将体细胞重新编程为较差分化状态的药剂的方法。
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公开(公告)号：US07682828B2
公开(公告)日：2010-03-23
申请号：US10997146
申请日：2004-11-24
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/85 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2506/1307 , C12N2510/00 , C12N2830/003 , C12N2830/006
摘要： The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.
摘要翻译： 本发明提供了重编程体细胞产生多潜能或多潜能细胞的方法。 这些方法可用于各种目的，包括治疗或预防个体的医疗状况。 本发明进一步提供了用于鉴定将体细胞重新编程为较差分化状态的药剂的方法。
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公开(公告)号：US09267123B2
公开(公告)日：2016-02-23
申请号：US13327558
申请日：2011-12-15
申请人： Rudolf Jaenisch , Josee Laganiere , Frank Soldner , Lei Zhang
发明人： Rudolf Jaenisch , Josee Laganiere , Frank Soldner , Lei Zhang
IPC分类号： C12N9/22
CPC分类号： C12N9/22 , A61K31/7088 , A61K48/00 , C07K14/4702 , C07K2319/00 , C07K2319/81 , C12N15/62 , C12N15/8509
摘要： Disclosed herein are methods and compositions for correction and/or mutation of genes associated with Parkinson's Disease as well as clones and animals derived therefrom.
摘要翻译： 本文公开了用于校正和/或突变与帕金森病相关基因以及由其衍生的克隆和动物的方法和组合物。
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7.发明申请COMPOSITIONS AND METHODS FOR DERIVING OR CULTURING PLURIPOTENT CELLS 审中-公开用于衍生或培养PLUIPOTENT细胞的组合物和方法公开(公告)号：US20110088107A1
公开(公告)日：2011-04-14
申请号：US12767606
申请日：2010-04-26
申请人： Yaqub Hanna , Rudolf Jaenisch
发明人： Yaqub Hanna , Rudolf Jaenisch
IPC分类号： C12N15/873 , C12N5/073
CPC分类号： A01K67/0271 , A01K2227/105 , C12N5/0606
摘要： The invention provides compositions and methods useful for deriving or culturing vertebrate ES cells. Certain inventive methods comprise deriving or culturing vertebrate ES cells using medium that comprises a compound that replaces Klf4 or c-Myc in generating iPS cells. The invention provides NOD ES cells and methods of deriving or culturing them.
摘要翻译： 本发明提供了可用于衍生或培养脊椎动物ES细胞的组合物和方法。 某些创造性方法包括使用包含替代Klf4或c-Myc的化合物的培养基来产生或培养脊椎动物ES细胞以产生iPS细胞。 本发明提供了NOD ES细胞及其衍生或培养方法。
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公开(公告)号：US20090099077A1
公开(公告)日：2009-04-16
申请号：US12134707
申请日：2008-06-06
CPC分类号： A61K38/30
摘要： The invention relates to methods for treatment of Rett Syndrome and other disorders of synaptic function and maturation using IGF1, (1-3)IGF-1, (1-3)IGF-1 analog(s) and/or related therapeutic molecules.
摘要翻译： 本发明涉及使用IGF1，（1-3）IGF-1，（1-3）IGF-1类似物和/或相关的治疗分子来治疗Rett综合征和其他突触功能和成熟障碍的方法。
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公开(公告)号：US09834787B2
公开(公告)日：2017-12-05
申请号：US12798749
申请日：2010-04-08
申请人： Philip D. Gregory , Dirk Hockemeyer , Michael C. Holmes , Rudolf Jaenisch , Frank Soldner , Fyodor Urnov , Shuyuan Yao
发明人： Philip D. Gregory , Dirk Hockemeyer , Michael C. Holmes , Rudolf Jaenisch , Frank Soldner , Fyodor Urnov , Shuyuan Yao
CPC分类号： C12N15/86 , C12N9/22 , C12N2710/10343 , C12N2740/15043 , C12N2800/30 , C12N2830/008
摘要： Disclosed herein are methods and compositions for targeted integration of sequences of interest such as lineage-specific or cell fate reporter constructs or protein encoding sequences into stem cells.
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10.发明申请公开(公告)号：US20110302665A1
公开(公告)日：2011-12-08
申请号：US13002334
申请日：2009-07-02
IPC分类号： A01K67/027 , C12N5/0781 , C12N5/071 , C12Q1/68 , A61K49/00 , C12N5/0735 , C12N5/0783 , G01N33/566
CPC分类号： C12N15/877 , A01K2227/105 , A01K2267/00 , A01K2267/02 , A01K2267/03 , C12N15/8775
摘要： The present invention provides non-human mammals, e.g., mice, generated from a T cell or B cell with a predefined specificity or isolated from an organism suffering from a condition of interest. In some embodiments the non-human mammals are not genetically modified. Also provided are methods of using the non-human animals.
摘要翻译： 本发明提供从具有预定义特异性的T细胞或B细胞产生的非人类哺乳动物，例如小鼠，或从感兴趣的病症分离的生物体分离。 在一些实施方案中，非人哺乳动物不经基因修饰。 还提供了使用非人动物的方法。
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