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    CODED HETEROFUNCTIONAL SUTURES AND METHODS
    3.
    发明申请
    CODED HETEROFUNCTIONAL SUTURES AND METHODS 审中-公开
    编码的异常方法和方法

    公开(公告)号：US20110264138A1

    公开(公告)日：2011-10-27

    申请号：US12992453

    申请日：2009-05-16

    申请人： Rui Avelar ,  Alexei Goraltchouk ,  Robert A. Herrmann ,  Brian H. Luscombe ,  William L. D'Agostino

    发明人： Rui Avelar ,  Alexei Goraltchouk ,  Robert A. Herrmann ,  Brian H. Luscombe ,  William L. D'Agostino

    IPC分类号： A61B17/04

    CPC分类号： A61B17/06166 ,  A61B90/92 ,  A61B90/94 ,  A61B2017/06176

    摘要： A marked heterofunctional surgical filament. The filament comprises two or more sections having different features, and the different sections of the filament are provided with markers in order that they may be identified and differentiated. The filament may have retainers on the surface of one or more sections such that the filament can engage and retain tissue without knots. The markers may be used to indicate fixed features of a section of filament such as the presence and/orientation of retainers. The markers may be utilized to indicate conditions of the filament such as tension. The markers may be directly readable or be machine-readable. The surgical filament is thin and flexible and may be used for suturing.

    摘要翻译： 标记异型手术丝。 灯丝包括具有不同特征的两个或更多个部分，并且灯丝的不同部分设置有标记，以便它们可以被鉴定和分化。 长丝可以在一个或多个部分的表面上具有保持器，使得细丝可以接合并保持组织而没有结。 标记可用于表示细丝部分的固定特征，例如保持器的存在和/取向。 标记可以用于指示细丝的状况，例如张力。 标记可以是直接可读的或机器可读的。 外科手术细丝薄而柔软，可用于缝合。

    METHOD AND APPARATUS FOR ELEVATING RETAINERS ON SELF-RETAINING SUTURES
    4.
    发明申请
    METHOD AND APPARATUS FOR ELEVATING RETAINERS ON SELF-RETAINING SUTURES 有权
    用于保留自保留保留物的方法和装置

    公开(公告)号：US20110046669A1

    公开(公告)日：2011-02-24

    申请号：US12866027

    申请日：2009-02-20

    申请人： Alexei Goraltchouk ,  Robert A. Herrmann ,  Lev Drubetsky ,  Jeffrey Mendel Gross ,  William L. D'Agostino ,  Carlos Gonzalez Resendiz

    发明人： Alexei Goraltchouk ,  Robert A. Herrmann ,  Lev Drubetsky ,  Jeffrey Mendel Gross ,  William L. D'Agostino ,  Carlos Gonzalez Resendiz

    IPC分类号： A61B17/04 ,  B26D3/00

    CPC分类号： A61B17/06166 ,  A61B2017/00526 ,  A61B2017/00867 ,  A61B2017/00871 ,  A61B2017/00995 ,  A61B2017/06176 ,  D02J3/10 ,  Y10T83/02

    摘要： A method and device to elevate retainers on a suture thread to a desired angle such that the retainers can retain the desired elevation. The retainers can be elevated using an apparatus having at least one roller and at least one bending bar, wherein the bending bar contacts the retainers adjacent to the at least one roller to apply a force to the retainers. The retainers can also be elevated using a tube-shaped apparatus which allows the retainers on a suture thread to be bent by the inner surface of the tube-shaped apparatus. In various embodiments of the invention, a suture can be made up of an inner core and a coating that upon a stimuli increases the protrusion of the retainers away from the suture core thereby ensuring that the suture is held securely in place, preventing wound separation and dehiscence. In an embodiment of the invention, the application of the coating to the outer face of the retainer and attractive forces between the coating at different points results in the distension of the retainers away from the suture core. In an alternative embodiment of the invention, the coating inserts into the cut associated with the retainer and repulsive or expansive forces result in a pushing out of the cut and thereby the distending of the retainers away from the suture core.

    摘要翻译： 一种将缝合线上的保持器提升到所需角度的方法和装置，使得保持器可以保持期望的高度。 保持器可以使用具有至少一个辊和至少一个弯曲杆的装置来提升，其中弯曲杆接触与至少一个辊相邻的保持器，以向保持器施加力。 保持器也可以使用允许缝合线上的保持器被管状装置的内表面弯曲的管状装置来升高。 在本发明的各种实施例中，缝合线可以由内芯和涂层组成，其在刺激时增加保持器远离缝合线芯的突起，从而确保缝合线牢固地保持就位，防止缠绕分离， 裂开。 在本发明的一个实施例中，将涂层施加到保持器的外表面和在不同点处的涂层之间的吸引力导致保持器远离缝合线芯的扩张。 在本发明的替代实施例中，与保持器相关联的切口中的涂层插入物和排斥力或膨胀力导致切口的推出，从而保持器远离缝合线芯的膨胀。

    COMBINING SYNTHETIC, NATURAL POLYMERS AND RECOMBINANT POLYMERS TO FORM MONOFILAMENT AND MULTIFILAMENT SELF-RETAINING SUTURES
    6.
    发明申请
    COMBINING SYNTHETIC, NATURAL POLYMERS AND RECOMBINANT POLYMERS TO FORM MONOFILAMENT AND MULTIFILAMENT SELF-RETAINING SUTURES 审中-公开
    组合合成，自然聚合物和重组聚合物形成单峰和多重自身保留物

    公开(公告)号：US20110022086A1

    公开(公告)日：2011-01-27

    申请号：US12740960

    申请日：2008-10-31

    申请人： William L. D'Agostino ,  Alexei Goraltchouk

    发明人： William L. D'Agostino ,  Alexei Goraltchouk

    IPC分类号： A61L17/00 ,  A61B17/04

    CPC分类号： A61L17/145 ,  A61L17/08 ,  A61L17/10

    摘要： The present invention combines synthetic, natural and recombinant polymers for making a self-retaining suture. In an embodiment of the present invention recombinant polyhydroxyalkanoate (rPHA) polymers and/or polyglycolic acid polymers are incorporated into the suture. In various embodiments of the invention, materials are incorporated into the suture to illicit a tissue response reaction. The tissue response reaction results in deposition of collagen around the tissue retainer in the tissue thereby increasing the retention of the tissue retainer in the tissue. In various embodiments of the invention, the core of the suture is made from a material that does not illicit a tissue response reaction. In various embodiments of the invention, the core can be chose to enhance elasticity and strength of the suture.

    摘要翻译： 本发明将合成，天然和重组聚合物结合在一起用于制造自固位缝线。 在本发明的一个实施方案中，将重组聚羟基链烷酸酯（rPHA）聚合物和/或聚乙醇酸聚合物掺入缝合线中。 在本发明的各种实施方案中，将材料并入缝合线以非法组织反应反应。 组织反应反应导致胶原周围组织保持器在组织中的沉积，从而增加组织保持器在组织中的保留。 在本发明的各种实施例中，缝合线的芯由不对组织反应反应非法的材料制成。 在本发明的各种实施例中，可以选择该芯以提高缝线的弹性和强度。

    Self-retaining suture with variable dimension filament and method
    7.
    发明授权
    Self-retaining suture with variable dimension filament and method 有权
    具有可变尺寸长丝和方法的自固定缝合线

    公开(公告)号：US08641732B1

    公开(公告)日：2014-02-04

    申请号：US12392955

    申请日：2009-02-25

    申请人： Alexei Goraltchouk ,  Alexander Naimagon ,  Gerald F. Cummings ,  Lev Drubetsky ,  Robert A. Herrmann

    发明人： Alexei Goraltchouk ,  Alexander Naimagon ,  Gerald F. Cummings ,  Lev Drubetsky ,  Robert A. Herrmann

    IPC分类号： A61B17/04

    CPC分类号： A61B17/06166 ,  A61B2017/00526 ,  A61B2017/00849 ,  A61B2017/00893 ,  A61B2017/06176 ,  D01D5/20 ,  D01D5/22

    摘要： A self-retaining suture comprises a variable-dimension filament which varies in size and/or shape along the length of the filament. The variation in size and/or shape results in a variation in the distribution of filament material from one region of the filament to the next. The filament has retainers formed in the surface such that the filament can engage and retain tissue. The retainers are formed in a manner that makes use of regions of the filament where additional material is distributed. The resulting self-retaining suture has a greater minimum cross-section than would be created using an equivalent uniform filament. The resulting self-retaining suture consequently has a greater tensile strength. Methods for manufacturing the filament and retainers are also described.

    摘要翻译： 自固位缝合线包括沿着长丝长度变化大小和/或形状的可变尺寸长丝。 尺寸和/或形状的变化导致细丝材料从细丝的一个区域到下一个区域的分布的变化。 灯丝具有形成在表面中的保持器，使得灯丝可以接合并保持组织。 保持器以这样的方式形成，即使用分布有附加材料的细丝的区域。 所产生的自固位缝合线具有比使用等效的均匀细丝产生的更大的最小横截面。 因此，所得到的自固位缝合线具有更大的拉伸强度。 还描述了制造丝和保持器的方法。

    Self-retaining sutures with retainers formed from molten material
    9.
    发明授权
    Self-retaining sutures with retainers formed from molten material 有权
    带有由熔融材料形成的保持器的自固定缝合线

    公开(公告)号：US08916077B1

    公开(公告)日：2014-12-23

    申请号：US12340444

    申请日：2008-12-19

    申请人： Alexei Goraltchouk ,  Lev Drubetsky ,  Gerald F. Cummings ,  Robert A. Herrmann ,  Alexander Naimagon

    发明人： Alexei Goraltchouk ,  Lev Drubetsky ,  Gerald F. Cummings ,  Robert A. Herrmann ,  Alexander Naimagon

    IPC分类号： B29C70/74 ,  B29C70/68

    CPC分类号： B29C70/68 ,  B29C70/74

    摘要： Provided herein are sutures to be used in a procedure applied to tissue, and methods for forming such sutures. A suture can include an elongated suture body having a periphery, and a plurality of retainers formed from molten material applied to portions of the periphery. The retainers can extend from and be arranged along at least a segment of the elongated suture body. The retainers can be formed by applying molten material to portions of the periphery of the elongated suture body and cooling the material to form the retainers.

    摘要翻译： 本文提供了用于施用于组织的程序中的缝线以及用于形成这种缝合线的方法。 缝合线可以包括具有周边的细长缝合线体，以及由施加到周边部分的熔融材料形成的多个保持器。 保持器可以沿着细长缝线体的至少一段延伸并且沿其布置。 可以通过将熔融材料施加到细长缝合线体的周边部分并冷却材料以形成保持器来形成保持器。