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    Process for producing hyper-comb-branched polymers
    2.
    发明授权
    Process for producing hyper-comb-branched polymers 失效
    生产超梳型支化聚合物的方法

    公开(公告)号：US5631329A

    公开(公告)日：1997-05-20

    申请号：US408833

    申请日：1995-03-21

    申请人： Rui Yin ,  Donald A. Tomalia ,  David M. Hedstrand ,  Douglas R. Swanson

    发明人： Rui Yin ,  Donald A. Tomalia ,  David M. Hedstrand ,  Douglas R. Swanson

    IPC分类号： A61K47/48 ,  C08G69/44 ,  C08G69/48 ,  C08G73/02 ,  C08G83/00 ,  C08G85/00 ,  C08F293/00

    CPC分类号： B82Y5/00 ,  A61K47/48961 ,  C08G69/44 ,  C08G69/48 ,  C08G73/0206 ,  C08G73/0233 ,  C08G83/005 ,  C08G85/00 ,  Y10S525/902

    摘要： The specification discloses a process for producing poly-branched polymer having relatively high molecular weight by forming a first set of branches by polymerizing monomers which are either protected against or are non-reactive to branching and grafting during polymerization, grafting that first set of branches to a core having a plurality of reactive sites capable of reacting with the reactive end units of said branches, either deprotecting or activating a plurality of monomeric units on each of said branches to create branch reactive sites, forming a second set of branches in the same manner as the first set of branches were formed, grafting the second set of branches to the first set of branches by reacting the reactive end units of the second set of branches with each said branch reactive site on said first set of branches and repeating the foregoing steps reiteratively to form and attach subsequent sets of branches to prior branch sets until a desired number of iterations has been effected.

    摘要翻译： 本说明书公开了一种制备具有相对较高分子量的多支化聚合物的方法，通过聚合单体聚合形成第一组分支，所述单体在聚合过程中被保护为不支化或不反应支化和接枝，将第一组分支移植到 具有能够与所述分支的反应性末端单元反应的多个反应性位点的核心，在每个所述分支上去保护或活化多个单体单元以产生分支反应位点，以相同方式形成第二组分支 作为第一组分支形成，通过使第二组分支的反应性末端单元与所述第一组分支上的每个所述分支反应位点反应，将第二组分支移植到第一组分支，并重复上述步骤 重复地将随后的分支集合形成并附加到先前的分支集合，直到所需的迭代次数为蜜蜂 n影响。

    Disulfide-containing dendritic polymers
    5.
    发明授权
    Disulfide-containing dendritic polymers 失效
    含二硫化物的树枝状聚合物

    公开(公告)号：US6020457A

    公开(公告)日：2000-02-01

    申请号：US941527

    申请日：1997-09-30

    申请人： June W. Klimash ,  Herbert M. Brothers, II ,  Douglas R. Swanson ,  Rui Yin ,  Ralph Spindler ,  Donald A. Tomalia ,  Yong Hsu ,  Roberta C. Cheng

    发明人： June W. Klimash ,  Herbert M. Brothers, II ,  Douglas R. Swanson ,  Rui Yin ,  Ralph Spindler ,  Donald A. Tomalia ,  Yong Hsu ,  Roberta C. Cheng

    IPC分类号： C08G83/00 ,  C08G69/00 ,  C08G73/00

    CPC分类号： C08G83/003 ,  B82Y30/00 ,  B82Y40/00 ,  Y10S424/16

    摘要： Dendritic polymers containing disulfide functional groups which are essentially inert under non-reducing conditions, but which form sulfhydryl groups upon being subjected to a reducing agent are prepared by synthesizing dendritic polymers having a core with a disulfide linkage or by reacting a dendritic polymer with a molecule containing a disulfide linkage and reactive terminal groups. In one aspect of the invention, dendritic polymers having a single disulfide functional group at the core are provided. The single disulfide group at the core can be reduced to form two sulfhydryl groups to which other molecules, such as proteins, oligonucleotides, peptides, hormones, other dendritic polymers, non-dendritic polymers, etc., can be bound. Applications for the disulfide functionalized dendritic polymers include formation of differentiated dendrimers, formation of binding reagents for diagnostics, drug delivery, gene therapy and magnetic resins imaging, and in the preparation of self-assembled dendrimer monolayers on a quartz crystal resonators to provide dendrimer-modified electrodes which are useful for detecting various ions or molecules. In another aspect of the invention, dendritic polymers having sulfhydryl terminals are provided. The sulfhydryl terminated dendritic polymers can be used to prepare stable, curable resins composition which can undergo cross linking when subjected to a reducing agent.

    摘要翻译： 通过合成具有核心与二硫键的树枝状聚合物或通过使树枝状聚合物与分子反应而制备的含二硫键官能团的树枝状聚合物在非还原条件下基本上为惰性但在形成巯基后形成巯基的树枝状聚合物 含有二硫键和反应性末端基团。 在本发明的一个方面，提供了在核心具有单个二硫键官能团的树枝状聚合物。 可以将核心上的单个二硫基团还原形成两个巯基，其中可以结合其它分子，例如蛋白质，寡核苷酸，肽，激素，其他树状聚合物，非树枝状聚合物等。 用于二硫化物官能化树枝状聚合物的应用包括形成分化的树枝状大分子，形成用于诊断的结合试剂，药物递送，基因治疗和磁性树脂成像，以及在石英晶体共振器上制备自组装树枝状聚合物单层以提供树枝状聚合物修饰 用于检测各种离子或分子的电极。 在本发明的另一方面，提供了具有巯基末端的树枝状聚合物。 巯基封端的树枝状聚合物可用于制备当经受还原剂时可以进行交联的稳定的可固化树脂组合物。