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    Multifunctional nanodevice platform
    2.
    发明授权
    Multifunctional nanodevice platform 失效
    多功能纳米设备平台

    公开(公告)号：US06471968B1

    公开(公告)日：2002-10-29

    申请号：US09570198

    申请日：2000-05-12

    申请人： James R. Baker, Jr. ,  Donald A. Tomalia

    发明人： James R. Baker, Jr. ,  Donald A. Tomalia

    IPC分类号： C07H2104

    CPC分类号： B82Y5/00 ,  A61K41/0057 ,  A61K41/0071 ,  A61K47/6949 ,  C08G83/003

    摘要： The present invention relates to novel therapeutic and diagnostic arrays. More particularly, the present invention is directed to dendrimer based multifunctional compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems generally comprise two or more separate components for targeting, imaging, sensing, and/or triggering release of a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).

    摘要翻译： 本发明涉及新的治疗和诊断阵列。 更具体地，本发明涉及用于疾病诊断和治疗（例如癌症诊断和治疗）的基于树枝状大分子的多功能组合物和系统。 组合物和系统通常包含用于靶向，成像，感测和/或触发治疗或诊断材料释放并监测对细胞或组织（例如肿瘤）的治疗的反应的两个或更多个单独组分。

    Methods of preventing and treating microbial infections
    5.
    发明授权
    Methods of preventing and treating microbial infections 有权
    预防和治疗微生物感染的方法

    公开(公告)号：US06506803B1

    公开(公告)日：2003-01-14

    申请号：US09561111

    申请日：2000-04-28

    申请人： James R. Baker, Jr. ,  Tarek Hamouda ,  Amy Shih ,  Andrzej Myc

    发明人： James R. Baker, Jr. ,  Tarek Hamouda ,  Amy Shih ,  Andrzej Myc

    IPC分类号： A01N2500

    CPC分类号： A61K9/1075 ,  A61K45/06 ,  Y02A50/475 ,  Y02A50/481 ,  Y10S514/938

    摘要： The present invention provides methods and compositions for inactivating bacteria including bacterial spores using an oil-in-water emulsion are provided. The oil-in-water emulsion comprises an oil, a surfactant and an organic phosphate-based solvent. These methods can be used to inactivate a wide variety of microorganisms including bacteria, bacterial spores, fungi, fungal spores and enveloped viruses.

    摘要翻译： 本发明提供了使用水包油乳液灭活包括细菌孢子在内的细菌的方法和组合物。 水包油乳液包含油，表面活性剂和有机磷酸盐基溶剂。 这些方法可用于灭活多种微生物，包括细菌，细菌孢子，真菌，真菌孢子和包膜病毒。

    Antimicrobial compositions and methods of use
    9.
    发明授权
    Antimicrobial compositions and methods of use 有权
    抗微生物组合物和使用方法

    公开(公告)号：US07767216B2

    公开(公告)日：2010-08-03

    申请号：US09751059

    申请日：2000-12-29

    申请人： James R. Baker, Jr. ,  Tarek Hamouda ,  Amy Shih ,  Andrzej Myc

    发明人： James R. Baker, Jr. ,  Tarek Hamouda ,  Amy Shih ,  Andrzej Myc

    IPC分类号： A01N25/00 ,  A01N33/12 ,  A61K9/00

    CPC分类号： A61K9/1075 ,  A61K45/06

    摘要： The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs. In particular, decreased pathogenic organism infectivity, morbidity, and mortality is accomplished by contacting the pathogenic organism with an oil-in-water nanoemulsion comprising an oil, an organic solvent, and a surfactant dispersed in an aqueous phase.

    摘要翻译： 本发明涉及用于降低与各种致病生物体和病毒有关的感染性，发病率和死亡率的组合物和方法。 本发明还涉及用于对由致病菌和病毒定殖或以其它方式感染的区域进行净化的方法和组合物。 此外，本发明涉及用于降低食品中病原生物体的感染性的方法和组合物。 特别地，通过使致病生物与包含分散在水相中的油，有机溶剂和表面活性剂的水包油纳米乳液接触来实现降低的致病生物体的感染性，发病率和死亡率。