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公开(公告)号:US09145392B2
公开(公告)日:2015-09-29
申请号:US14237075
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Yufang Xiao , Xiaoling Chen , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
发明人: Ruoxi Lan , Bayard R. Huck , Yufang Xiao , Xiaoling Chen , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
IPC分类号: C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/5377 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/107
CPC分类号: A61K31/506 , A61K31/4545 , A61K31/5377 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/107
摘要: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)和式(II)的新型咪唑胺化合物,其用于治疗过度增殖性疾病如癌症的制造和用途。
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公开(公告)号:US20140343029A1
公开(公告)日:2014-11-20
申请号:US14237075
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
IPC分类号: C07D401/14 , A61K31/506 , C07D413/14 , C07D491/107 , C07D409/14 , C07D417/14 , A61K31/5377 , A61K31/4545
CPC分类号: A61K31/506 , A61K31/4545 , A61K31/5377 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/107
摘要: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)和式(II)的新型咪唑胺化合物,其用于治疗过度增殖性疾病如癌症的制造和用途。
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公开(公告)号:US08735584B2
公开(公告)日:2014-05-27
申请号:US12919136
申请日:2009-02-25
申请人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
发明人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
IPC分类号: C07D471/04 , C07D471/06
CPC分类号: C07D471/04
摘要: Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation.
摘要翻译: 公开了苯并萘并吡啶基衍生物化合物及其类似物,包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于激酶信号转导抑制,调节或调节的疾病。
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公开(公告)号:US20110053906A1
公开(公告)日:2011-03-03
申请号:US12919136
申请日:2009-02-25
申请人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
发明人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
IPC分类号: A61K31/4745 , C07D471/04 , A61K31/5377 , A61K31/496 , A61K31/536 , A61P35/00
CPC分类号: C07D471/04
摘要: Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation.
摘要翻译: 公开了苯并萘并吡啶基衍生物化合物及其类似物,包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于激酶信号转导抑制,调节或调节的疾病。
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公开(公告)号:US08853391B2
公开(公告)日:2014-10-07
申请号:US13140357
申请日:2009-12-03
申请人: Bayard R. Huck , Amanda E. Sutton , Benny C. Askew, Jr. , Christopher Charles Victor Jones , Garry R. Smith , Nadia Brugger
发明人: Bayard R. Huck , Amanda E. Sutton , Benny C. Askew, Jr. , Christopher Charles Victor Jones , Garry R. Smith , Nadia Brugger
IPC分类号: C07D401/14 , C07D413/14 , C07D471/14 , C07D471/04
CPC分类号: C07D471/04
摘要: Disclosed are dipyridyl-pyrrole derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
摘要翻译: 公开了联吡啶基 - 吡咯衍生物化合物及其类似物,包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于蛋白激酶信号转导抑制,调节和/或调节的疾病。
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公开(公告)号:US20120022060A1
公开(公告)日:2012-01-26
申请号:US13140357
申请日:2009-12-03
申请人: Bayard R. Huck , Amanda E. Sutton , Benny C. Askew, JR. , Christopher Charles Victor Jones , Garry R. Smith , Nadia Brugger
发明人: Bayard R. Huck , Amanda E. Sutton , Benny C. Askew, JR. , Christopher Charles Victor Jones , Garry R. Smith , Nadia Brugger
IPC分类号: A61K31/5377 , C07D413/14 , C07D401/14 , A61P19/10 , A61K31/497 , A61P35/00 , A61P9/10 , C07D471/14 , A61K31/4375
CPC分类号: C07D471/04
摘要: Disclosed are dipyridyl-pyrrole derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
摘要翻译: 公开了联吡啶基 - 吡咯衍生物化合物及其类似物,包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于蛋白激酶信号转导抑制,调节和/或调节的疾病。
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