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    Microprocessors, devices, and methods for use in monitoring of physiological analytes
    1.
    发明申请
    Microprocessors, devices, and methods for use in monitoring of physiological analytes 审中-公开
    用于监测生理分析物的微处理器，装置和方法

    公开(公告)号：US20060127964A1

    公开(公告)日：2006-06-15

    申请号：US11350193

    申请日：2006-02-08

    申请人： Russell Ford ,  Matthew Lesho ,  Janet Tamada ,  Michael Tierney

    发明人： Russell Ford ,  Matthew Lesho ,  Janet Tamada ,  Michael Tierney

    IPC分类号： C12Q1/54 ,  G06F19/00

    CPC分类号： A61B5/14532 ,  A61B5/4266 ,  A61B5/4283 ,  A61B5/4881 ,  A61B5/7267 ,  G16H40/63

    摘要： Described herein are microprocessors, devices, and methods useful for sweat and/or temperature detection that correlate more closely with changes in amperometric or charge signals related to analyte amount or concentration. The present invention provides methods for the establishment of more accurate sweat and/or temperature thresholds and new methods of compensation, such as correcting for the effects of sweat and rapidly changing temperature on measured analyte values. The present invention reduces the number of skipped or unuseable readings provided by analyte monitoring devices during periods of sweating or changing temperatures. Further, the present invention provides methods for improving the accuracy of reported readings of analyte amount or concentration. In one aspect, the present invention provides passive collection reservoir/sensing devices used in combination with active collection reservoir/sensing devices for detection of sweat and/or temperature related parameters.

    摘要翻译： 本文描述的是用于汗液和/或温度检测的微处理器，装置和方法，其更接近于与分析物量或浓度相关的电流或电荷信号的变化。 本发明提供了用于建立更准确的汗液和/或温度阈值和新的补偿方法的方法，例如校正汗液和快速变化的温度对测量的分析物值的影响。 本发明在出汗或变化的温度期间减少由分析物监测装置提供的跳过或不可用读数。 此外，本发明提供了提高分析物量或浓度的报告读数精度的方法。 在一个方面，本发明提供与用于检测汗和/或温度相关参数的主动收集储存器/感测装置组合使用的被动收集储存器/感测装置。

    Microprocessors, devices, and methods for use in monitoring of physiological analytes
    2.
    发明申请
    Microprocessors, devices, and methods for use in monitoring of physiological analytes 审中-公开
    用于监测生理分析物的微处理器，装置和方法

    公开(公告)号：US20050069925A1

    公开(公告)日：2005-03-31

    申请号：US10903672

    申请日：2004-07-30

    申请人： Russell Ford ,  Matthew Lesho ,  Janet Tamada ,  Michael Tierney

    发明人： Russell Ford ,  Matthew Lesho ,  Janet Tamada ,  Michael Tierney

    IPC分类号： A61B5/00 ,  G06F19/00 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50

    CPC分类号： A61B5/4283 ,  A61B5/14532 ,  A61B5/4266 ,  A61B5/4881 ,  A61B5/7267 ,  A61B2560/0252 ,  G16H40/63

    摘要： Described herein are microprocessors, devices, and methods useful for sweat and/or temperature detection that correlate more closely with changes in amperometric or charge signals related to analyte amount or concentration. The present invention provides methods for the establishment of more accurate sweat and/or temperature thresholds and new methods of compensation, such as correcting for the effects of sweat and rapidly changing temperature on measured analyte values. The present invention reduces the number of skipped or unuseable readings provided by analyte monitoring devices during periods of sweating or changing temperatures. Further, the present invention provides methods for improving the accuracy of reported readings of analyte amount or concentration. In one aspect, the present invention provides passive collection reservoir/sensing devices used in combination with active collection reservoir/sensing devices for detection of sweat and/or temperature related parameters.

    摘要翻译： 本文描述的是用于汗液和/或温度检测的微处理器，装置和方法，其更接近于与分析物量或浓度相关的电流或电荷信号的变化。 本发明提供了用于建立更准确的汗液和/或温度阈值和新的补偿方法的方法，例如校正汗液和快速变化的温度对测量的分析物值的影响。 本发明在出汗或变化的温度期间减少由分析物监测装置提供的跳过或不可用读数。 此外，本发明提供了提高分析物量或浓度的报告读数精度的方法。 在一个方面，本发明提供与用于检测汗和/或温度相关参数的主动收集储存器/感测装置组合使用的被动收集储存器/感测装置。

    Formulation and manipulation of databases of analyte and associated values
    4.
    发明申请
    Formulation and manipulation of databases of analyte and associated values 有权
    分析物和相关值的数据库的制备和操作

    公开(公告)号：US20050010093A1

    公开(公告)日：2005-01-13

    申请号：US10821055

    申请日：2004-04-08

    申请人： Russell Ford ,  Matthew Lesho ,  Russell Potts ,  Michael Tierney ,  Charles Wei

    发明人： Russell Ford ,  Matthew Lesho ,  Russell Potts ,  Michael Tierney ,  Charles Wei

    IPC分类号： G06F19/00 ,  A61B5/00

    CPC分类号： G16H10/40 ,  G06F19/00 ,  G06F19/3456 ,  G16H10/60 ,  G16H40/63 ,  Y10S707/99945 ,  Y10S707/99948

    摘要： The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.

    摘要翻译： 本发明涉及配制分析物数据数据库的方法，数据库本身及其操作方法。 一方面，本发明包括分析物数据点，派生数据和数据属性数据库的配方，其包括使用能够频繁地监测分析物浓度或量的分析物监测装置收集的数据点。 这样的数据点可以包括获取的数据（例如，对应于由所述分析物监测装置测量的分析物浓度或量的值）。 然后将这些数据点与一个或多个相关数据属性相关联。 可以操纵生成的数据库以确定数据库的组件之间的关系。

    Methods of producing an assembly for use in a monitoring device
    5.
    发明授权
    Methods of producing an assembly for use in a monitoring device 有权
    制造用于监测装置的组件的方法

    公开(公告)号：US06370410B2

    公开(公告)日：2002-04-09

    申请号：US09764550

    申请日：2001-01-18

    申请人： Ronald T. Kurnik ,  Janet Tamada ,  Michael Tierney

    发明人： Ronald T. Kurnik ,  Janet Tamada ,  Michael Tierney

    IPC分类号： A61B507

    CPC分类号： A61B5/1486 ,  A61N1/30 ,  C12Q1/001 ,  C12Q1/002 ,  C12Q1/006

    摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

    摘要翻译： 化学信号不可渗透的掩模位于电解质流中，使得掩模位于化学信号源和感测从源传输的化学信号（例如通过扩散）的工作电极之间。 掩模的配置使得掩模基本上防止具有相对于掩模的平面和工作电极的催化面的径向矢量分量的化学信号源的所有化学信号传输，因此主要仅允许化学信号传输 基本上垂直于掩模的位置和工作电极的催化表面。 通过减少或消除朝向工作电极的化学信号径向传输，掩模因此显着地减少或消除了边缘效应。 通过显着降低由化学信号的径向传输产生的边缘效应，可以获得从源材料的给定区域输送的化学信号的量（例如，浓度）的更准确的测量。

    Chemical signal-impermeable mask
    8.
    发明授权
    Chemical signal-impermeable mask 有权

    公开(公告)号：US6141573A

    公开(公告)日：2000-10-31

    申请号：US128891

    申请日：1998-08-04

    申请人： Ronald T. Kurnik ,  Janet Tamada ,  Michael Tierney

    发明人： Ronald T. Kurnik ,  Janet Tamada ,  Michael Tierney

    IPC分类号： G01N27/30 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61N1/30 ,  C12Q1/00 ,  G01N27/416

    CPC分类号： A61B5/1486 ,  A61N1/30 ,  C12Q1/001 ,  C12Q1/002 ,  C12Q1/006

    摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

    Methods for monitoring a physiological analyte
    10.
    发明授权
    Methods for monitoring a physiological analyte 有权

    公开(公告)号：US06309351B1

    公开(公告)日：2001-10-30

    申请号：US09650024

    申请日：2000-08-28

    申请人： Ronald T. Kurnik ,  Janet Tamada ,  Michael Tierney ,  Russell Owen Potts

    发明人： Ronald T. Kurnik ,  Janet Tamada ,  Michael Tierney ,  Russell Owen Potts

    IPC分类号： A61B500

    CPC分类号： A61B5/14532

    摘要： A method for continual monitoring of a physiologic analyte in a subject includes steps of contacting the subject with a collection reservoir such that the analyte can move from the subject into the collection reservoir, the contents of the collection reservoir being in operative communication with a detector, collecting the analyte in the collection reservoir, using the detector to detect the analyte in the collection reservoir, and, once the analyte has been detected, rendering the analyte undetectable by the detector. Also, apparatus for continual monitoring of a physiologic analyte in a subject includes a collection reservoir for receiving the analyte from the subject, the contents of the collection reservoir being in operative relationship with a detector that detects the analyte in the reservoir, and means for rendering the analyte, once detected, undetectable by the reservoir.