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公开(公告)号:US20060030573A1
公开(公告)日:2006-02-09
申请号:US11248040
申请日:2005-10-11
申请人: Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
发明人: Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
IPC分类号: A61K31/519 , A61K31/517 , C07D239/88 , C07D403/02 , C07D487/02
CPC分类号: C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要: A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure IA, IB, or IC where the values of the variable are defined herein.
摘要翻译: 提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。 该化合物可用于治疗MC4-R介导的疾病。 化合物具有结构IA,IB或IC,其中变量的值在本文中定义。
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公开(公告)号:US20050059662A1
公开(公告)日:2005-03-17
申请号:US10850967
申请日:2004-05-21
申请人: Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher Conlee , Brian Thompson , Judith Kuntz , David Musso , Kevin Barvian , Stephen Thomson , William Swain , Kien Du , Brian Chauder , Jason Speake , Michael Bishop
发明人: Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher Conlee , Brian Thompson , Judith Kuntz , David Musso , Kevin Barvian , Stephen Thomson , William Swain , Kien Du , Brian Chauder , Jason Speake , Michael Bishop
IPC分类号: A61K31/517 , A61K31/519 , A61K31/525 , A61K31/53 , A61P3/04 , A61P3/10 , C07D217/24 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D417/14 , C07D471/04 , C07D475/02 , C07D487/02 , C07D487/04
CPC分类号: C07D217/24 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要: A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.
摘要翻译: 提供了能够作为MC4-R激动剂的各种小分子,含胍分子。 当给予受试者时,这些化合物可用于治疗MC4-R介导的疾病。 化合物具有结构IA,IB和IC,其中变量的值在本文中定义。
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公开(公告)号:US20060235019A1
公开(公告)日:2006-10-19
申请号:US10515434
申请日:2003-05-23
申请人: Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith
发明人: Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith
IPC分类号: A61K31/53 , A61K31/525 , A61K31/519 , C07D487/02 , C07D475/02
CPC分类号: C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要: A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of the variable are defined herein.
摘要翻译: 提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。 该化合物可用于治疗MC4-R介导的疾病。 化合物具有式(IA),(IB)或(IC)的结构:其中变量的值在本文中定义。
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公开(公告)号:US07034033B2
公开(公告)日:2006-04-25
申请号:US10444495
申请日:2003-05-23
申请人: Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
发明人: Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
IPC分类号: C07D239/90 , A61K31/517 , A61P3/04 , A61P3/10
CPC分类号: C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要: A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure IA, IB, or IC where the values of the variable are defined herein.
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公开(公告)号:US07858641B2
公开(公告)日:2010-12-28
申请号:US11248040
申请日:2005-10-11
申请人: Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
发明人: Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
IPC分类号: A61K31/47
CPC分类号: C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要: A variety of low molecular weight, guanidino-containing dihydroisoquinolinoines capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure ID where the values of the variable are defined herein.
摘要翻译: 提供了能够作为MC4-R激动剂的各种低分子量含胍基的二氢异喹啉基。 该化合物可用于治疗MC4-R介导的疾病。 化合物具有其中在此定义变量的值的结构ID。
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公开(公告)号:US07625909B2
公开(公告)日:2009-12-01
申请号:US10850967
申请日:2004-05-21
申请人: Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher R. Conlee , Brian D. Thompson , Judith de Armas Kuntz , David L. Musso , Kevin K. Barvian , Stephen A. Thomson , William R. Swain , Kien S. Du , Brian A. Chauder , Jason D. Speake , Michael J. Bishop
发明人: Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher R. Conlee , Brian D. Thompson , Judith de Armas Kuntz , David L. Musso , Kevin K. Barvian , Stephen A. Thomson , William R. Swain , Kien S. Du , Brian A. Chauder , Jason D. Speake , Michael J. Bishop
IPC分类号: A61K31/517 , A61K31/519 , A61P5/50 , C07D239/88 , C07D239/95 , C07D471/04 , C07D487/04
CPC分类号: C07D217/24 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要: A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.
摘要翻译: 提供了能够作为MC4-R激动剂的各种小分子,含胍分子。 当给予受试者时,这些化合物可用于治疗MC4-R介导的疾病。 化合物具有结构IA,IB和IC,其中变量的值在本文中定义。
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公开(公告)号:US07858631B2
公开(公告)日:2010-12-28
申请号:US10515434
申请日:2003-05-23
申请人: Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
发明人: Rustum S. Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Bryan Chang
IPC分类号: A61K31/519
CPC分类号: C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要: A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of the variable are defined herein.
摘要翻译: 提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。 该化合物可用于治疗MC4-R介导的疾病。 化合物具有式(IA),(IB)或(IC)的结构:其中变量的值在本文中定义。
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公开(公告)号:US20100105654A1
公开(公告)日:2010-04-29
申请号:US12605174
申请日:2009-10-23
申请人: Rustum S. BOYCE , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher R. Conlee , Brian D. Thompson , Judith de Armas Kuntz , David L. Musso , Kevin K. Barvian , Stephen A. Thomson , William R. Swain , Kien S. Du , Brian A. Chauder , Jason D. Speake , Michael J. Bishop
发明人: Rustum S. BOYCE , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher R. Conlee , Brian D. Thompson , Judith de Armas Kuntz , David L. Musso , Kevin K. Barvian , Stephen A. Thomson , William R. Swain , Kien S. Du , Brian A. Chauder , Jason D. Speake , Michael J. Bishop
IPC分类号: A61K31/517 , C07D403/12 , C07D239/86 , C07D403/14 , C07D413/14 , C07D417/14 , A61K31/5377 , A61P3/04 , A61P3/10
CPC分类号: C07D217/24 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要: A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structures VA, VB, VIIA and VIIB where the values of the variables are defined herein.
摘要翻译: 提供了能够作为MC4-R激动剂的各种小分子,含胍分子。 当给予受试者时,这些化合物可用于治疗MC4-R介导的疾病。 化合物具有结构VA,VB,VIIA和VIIB,其中变量的值在本文中定义。
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公开(公告)号:US20050124597A1
公开(公告)日:2005-06-09
申请号:US10503401
申请日:2003-02-03
申请人: Rustum Boyce , Daniel Chu , David P. Lentini
发明人: Rustum Boyce , Daniel Chu , David P. Lentini
CPC分类号: C07K5/06165 , A61K38/00 , C07K5/06139
摘要: A variety of small, guanidino group-containing molecules capable of acting as MC4-R agonists are provided. The compounds have various structures provided herein. The compounds are useful in treating MC4-R mediated diseases and may be formulated into pharmaceutical formulations and compositions.
摘要翻译: 提供了能够作为MC4-R激动剂的各种含有胍基的小分子。 化合物具有本文提供的各种结构。 该化合物可用于治疗MC4-R介导的疾病,并且可以配制成药物制剂和组合物。
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公开(公告)号:US07456183B2
公开(公告)日:2008-11-25
申请号:US10474331
申请日:2002-04-08
申请人: Daniel Chu , Rustum Boyce , David Duhl , Bryan Chang
发明人: Daniel Chu , Rustum Boyce , David Duhl , Bryan Chang
IPC分类号: A61K31/47 , A61K31/425 , A61K31/415 , A61K31/40 , A61P7/00 , C07D209/02 , C07D209/44 , C07D209/46 , C07D209/48 , C07D217/22 , C07D235/24 , C07D235/28 , C07D277/62 , C07D403/02
CPC分类号: C07D209/46 , C07D209/48 , C07D217/24 , C07D235/08 , C07D235/10
摘要: Compounds having the general structure I are provided. X and Y are independently selected from the group consisting of CH2, N, NR9, C═O, C═S, S═O, SO2, S, O, (CR6R7)n, C(═O)—(CR6R7)n, and C(═S)—(CR6R7)n, where n is 1, 2, or 3. W is selected from the group consisting of (formula I) and L is selected from the group consisting of N, O, S═O, SO2, C(O), NC(O), NC(S), OC(O), OC(S), C(NR10), C(NOR10), and a covalent bond. Z1, Z2, and Z3 are independently selected from the group consisting of substituted carbon and nitrogen. Compounds of formula I are agonists of the melanocortin-4 receptor (“MC-4r2) and therefore may have useful properties for controlling diseases related to MC-4r action in humans, such as obesity and type II diabetes.
摘要翻译: 提供具有一般结构I的化合物。 X和Y独立地选自CH 2,N,NR 9,CO,CS,SO,SO 2,S ,(O) - (CR 6),(O) - (CR 6) C(-S) - (CR 6 R 7)N O>,和C(-S) - (CR 6) 其中n为1,2或3.W选自(式I),L选自N,O,SO,SO 2, C(O),NC(O),NC(S),OC(O),OC(S),C(NR 10) ,和共价键。 Z 1,Z 2,Z 3和Z 3独立地选自取代的碳和氮。 式I化合物是黑皮质素-4受体(“MC-4r2”)的激动剂,因此可能具有控制人类MC-4r作用相关疾病如肥胖和II型糖尿病的有用性质。
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