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公开(公告)号：US07314879B2
公开(公告)日：2008-01-01
申请号：US10500476
申请日：2003-01-21
申请人： Ryan Thomas Backer , Caño Ivan Collado , Oscar De Frutos-Garcia , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Chaoyu Xie
发明人： Ryan Thomas Backer , Caño Ivan Collado , Oscar De Frutos-Garcia , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Chaoyu Xie
IPC分类号： A61K31/496 , C07D401/12 , C07D405/12 , C07D407/12
CPC分类号： C07D217/26 , C07D209/44 , C07D211/26 , C07D211/96 , C07D295/033 , C07D309/04 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to melanocortin receptor agonist of the formula (I): which is useful in the treatment for obesity, diabetes, and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式（I）的黑皮质素受体激动剂：其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍
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公开(公告)号：US07169777B2
公开(公告)日：2007-01-30
申请号：US10466250
申请日：2002-01-23
申请人： Ryan Thomas Backer , Karin Briner , Ivan Collado Caño , Oscar De Frutos Garcia , Christopher William Doecke , Matthew Joseph Fisher , Cristina Garcia-Paredes , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Ana Isabel Mateo Herranz , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Zhipei Wu , Chaoyu Xie
发明人： Ryan Thomas Backer , Karin Briner , Ivan Collado Caño , Oscar De Frutos Garcia , Christopher William Doecke , Matthew Joseph Fisher , Cristina Garcia-Paredes , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Ana Isabel Mateo Herranz , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Zhipei Wu , Chaoyu Xie
IPC分类号： A61K31/496 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , A61K31/551
CPC分类号： C07D209/48 , A61K38/00 , C07D209/44 , C07D217/12 , C07D217/16 , C07D217/26 , C07K5/06191
摘要： The present invention relates to melanocortin receptor agonist of the formula I useful in the treatment of obesity, diabetes, and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式I的黑皮质素受体激动剂，其用于治疗肥胖症，糖尿病以及男性和/或女性性功能障碍
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公开(公告)号：US07291619B2
公开(公告)日：2007-11-06
申请号：US10466121
申请日：2002-01-23
申请人： Christopher Kelly Biggers , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Larry Wayne Hertel , Vincent Mancuso , Michael John Martinelli , John Philip Mayer , Paul Leslie Ornstein , Timothy Ivo Richardson , Jikesh Arvind Shah , Qing Shi , Zhipei Wu , Chaoyu Xie
发明人： Christopher Kelly Biggers , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Larry Wayne Hertel , Vincent Mancuso , Michael John Martinelli , John Philip Mayer , Paul Leslie Ornstein , Timothy Ivo Richardson , Jikesh Arvind Shah , Qing Shi , Zhipei Wu , Chaoyu Xie
IPC分类号： A61K31/496 , C07D217/26 , C07D209/44
CPC分类号： A61K45/06 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to melanocortin receptor agonists of formula (I), which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式（I）的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍
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公开(公告)号：US06713516B2
公开(公告)日：2004-03-30
申请号：US10318483
申请日：2002-12-12
申请人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K3118
CPC分类号： C07D213/42 , C07C311/03 , C07C311/04 , C07D213/26 , C07D213/81 , C07D333/16 , C07D333/20
摘要： The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
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公开(公告)号：US06552086B1
公开(公告)日：2003-04-22
申请号：US09744409
申请日：2001-01-23
申请人： Macklin Brian Arnold , Paul Leslie Ornstein , Edward C. R. Smith , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , Paul Leslie Ornstein , Edward C. R. Smith , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K3118
CPC分类号： C07C311/13 , C07C311/27
摘要： The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
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公开(公告)号：US07157582B2
公开(公告)日：2007-01-02
申请号：US11032759
申请日：2005-01-11
IPC分类号： C07D217/12
CPC分类号： C07D401/06 , A61K31/00 , A61K31/472 , A61K31/4725
摘要： The present invention provides a method of treating or preventing migraine comprising administering to a patient in need thereof an effective amount of a selective iGluR5 receptor antagonist. The present invention further provides novel compounds functional as selective iGluR5 receptor antagonists as well as compositions and formulations comprising said selective iGluR5 receptor antagonists.
摘要翻译： 本发明提供治疗或预防偏头痛的方法，其包括向有需要的患者施用有效量的选择性iGluR5受体拮抗剂。 本发明还提供了作为选择性iGluR 5受体拮抗剂的新型化合物以及包含所述选择性iGluR 5受体拮抗剂的组合物和制剂。
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公开(公告)号：US06358981B1
公开(公告)日：2002-03-19
申请号：US09744414
申请日：2001-01-23
申请人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： C07D23504
CPC分类号： C07D213/42 , C07C311/03 , C07C311/04 , C07D213/26 , C07D213/81 , C07D333/16 , C07D333/20
摘要： The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及使用某些磺酰胺衍生物增强谷氨酸受体功能。 它还涉及新型磺酰胺衍生物，其制备方法和含有它们的药物组合物。
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公开(公告)号：US06355655B1
公开(公告)日：2002-03-12
申请号：US09744457
申请日：2001-01-23
申请人： Ana Maria Escribano , Winton Dennis Jones , Paul Leslie Ornstein , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Ana Maria Escribano , Winton Dennis Jones , Paul Leslie Ornstein , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K31445
CPC分类号： C07D207/09 , C07D211/28
摘要： The present invention relates to the potentiation of glutamate receptor function using certain heterocyclic sulphonamide derivatives. It also relates to novel heterocyclic sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及使用某些杂环磺酰胺衍生物增强谷氨酸受体功能。 它还涉及新型杂环磺酰胺衍生物，其制备方法和含有它们的药物组合物。
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公开(公告)号：US06174922B1
公开(公告)日：2001-01-16
申请号：US09251058
申请日：1999-02-23
IPC分类号： A61K3118
CPC分类号： C07C311/03 , C07C311/04 , C07C311/05 , C07C311/06 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D213/40 , C07D277/12 , C07D277/28 , C07D333/20 , C07D409/04
摘要： The present invention provides novel sulphonamide derivatives which are useful for potentiating glutamate receptor function in a mammal requiring treatment, processes for their preparation, and pharmaceutical compositions containing them.
摘要翻译： 本发明提供了可用于增强需要治疗的哺乳动物的谷氨酸受体功能的新型磺酰胺衍生物，其制备方法和含有它们的药物组合物。
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公开(公告)号：US06953805B2
公开(公告)日：2005-10-11
申请号：US10451819
申请日：2001-12-20
IPC分类号： A61K31/00 , A61K31/47 , A61P25/00 , A61P25/06 , C07D401/04 , C07D401/06 , C07D401/14
CPC分类号： C07D401/14 , C07D401/04 , C07D401/06
摘要： The present invention provides novel compounds of Formula I or Formula II, or the pharmaceutically acceptable salts or prodrugs thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I or Formula II in combination with a suitable carrier, diluent, or excipient, and methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine.
摘要翻译： 本发明提供式I或式II的新化合物或其药学上可接受的盐或前药，药物组合物包含有效量的式I或式II化合物与合适的载体，稀释剂或赋形剂的组合，和 治疗神经系统疾病和神经变性疾病，特别是疼痛和偏头痛的方法。
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